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(Circulation. 2005;112:1917.)
© 2005 American Heart Association, Inc.

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An extract of the first 250 words of the full text is provided, because this article has no abstract.

	EFFECT OF FISH OIL ON HEART RATE IN HUMANS: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS, by Mozaffarian et al.

 
Heart rate is determined by the complex interplay of sympathetic and parasympathetic stimulation with sinus node automaticity. Faster heart rates are associated with increasing mortality and cardiovascular risk, consistent with the observations that increased sympathetic tone activation is not only a marker of risk but also has direct adverse effects. ß-Adrenergic-blocking agents and physical conditioning slow the heart rate and are beneficial. Mozaffarian and colleagues show that consumption of fish oil also slows heart rate. In a meta-analysis of randomized trials including 1678 subjects who ingested fish oil for 4 to 52 weeks, heart rate slowed by 1.6 beats per minute. Whether this is mediated by an alteration in cardiac lipid membranes that affects ion channel function, as has been previously hypothesized, or a reduction in sympathetic tone through some other mechanism remains to be established. The findings suggest potential mechanisms for cardiovascular benefits of fish or fish oil consumption. See p 1945.

	COMPARISON OF PERCUTANEOUS CORONARY INTERVENTION AND CORONARY ARTERY BYPASS GRAFTING AFTER ACUTE MYOCARDIAL INFARCTION COMPLICATED BY CARDIOGENIC SHOCK: RESULTS FROM THE SHOULD WE EMERGENTLY REVASCULARIZE OCCLUDED CORONARIES FOR CARDIOGENIC SHOCK (SHOCK) TRIAL, by White et al.

 
Despite advances in reperfusion therapies, the incidence of cardiogenic shock has not changed, and it remains the most common cause of death in patients hospitalized with acute myocardial infarction. In the SHOCK trial, emergency revascularization, as compared with medical stabilization, resulted at 1 year in 130 lives saved per 1000 patients. Furthermore, most survivors had a good quality of life. To achieve this result, almost 40% of patients had emergency revascularization surgery. The SHOCK investigation compared the outcomes according to choice of PCI or CABG, which was done by site investigators. Patients treated with CABG had . . . [Full Text of this Article]

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