| ||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2005;112:2753.)
© 2005 American Heart Association, Inc.
Issue Highlights
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
 |
PULMONARY NEOVASCULARITY: A DISTINCTIVE RADIOGRAPHIC FINDING IN EISENMENGER SYNDROME, by Sheehan et al. |
|---|
Sheehan and colleagues characterized distinctive pulmonary vascular abnormalities seen on chest radiographs and computed tomography (CT) scans in 24 patients with Eisenmenger syndrome, as compared with 14 patients with acyanotic pulmonary artery hypertension (PAH). Eisenmenger patients had distinctive features on chest radiographs and CT scans more often than did those with acyanotic PAH. On CT, neovascularity, lobular ground glass, and increased systemic collaterals were identified regardless of the etiology of PAH, although they were significantly more common in Eisenmenger syndrome. Neovascularity and ground glass opacification were more prevalent and more severe in post-tricuspid defects in which pulmonary hypertension was present early in life, suggesting that the lesions were influenced by time of onset and duration of pulmonary vascular disease. See p 2778.
|
PIOGLITAZONE REDUCES NEOINTIMA VOLUME AFTER CORONARY STENT IMPLANTATION: A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND TRIAL IN NONDIABETIC PATIENTS, by Marx et al. |
|---|
Thiazolidinediones (TZDs) are a class of compounds commonly used to treat diabetes mellitus. These agents act as agonists for the peroxisome-proliferator-activated receptor-
(PPAR-) nuclear receptor that controls the expression of many genes involved in energy metabolism. Recently, in vitro and animal studies have implicated this class of nuclear receptors in the inflammatory response, although the applicability of these findings to humans remains unclear. In this issue, Marx and colleagues have advanced our knowledge of TZDs on human inflammation. Using restenosis as a model, they investigated the efficacy of TZDs on the response to arterial injury in a nondiabetic population. They provide clear evidence of an antiinflammatory effect that is independent of glucose control. See p 2792.
|
MAGNETIC RESONANCE ASSESSMENT OF THE SUBSTRATE FOR INDUCIBLE VENTRICULAR TACHYCARDIA IN NONISCHEMIC CARDIOMYOPATHY, by Nazarian et al. |
|---|
A vexing issue undergoing intense scrutiny involves optimizing selection
Related Articles:
Circulation 2005 112: 2778-2785.
Circulation 2005 112: 2821-2825.
Circulation 2005 112: e299-e301.
Circulation 2005 112: e302.
Circulation 2005 112: e303-e304.
Circulation 2005 112: e305.
Circulation 2005 112: e306.
Circulation 2005 112: 2792-2798.