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(Circulation. 2005;112:3025.)
© 2005 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	OPTIMAL TIMING OF INTERVENTION IN NON–ST-SEGMENT ELEVATION ACUTE CORONARY SYNDROMES: INSIGHTS FROM THE CRUSADE (CAN RAPID RISK STRATIFICATION OF UNSTABLE ANGINA PATIENTS SUPPRESS ADVERSE OUTCOMES WITH EARLY IMPLEMENTATION OF THE ACC/AHA GUIDELINES) REGISTRY, by Ryan et al.

 
An early invasive strategy for patients with non–ST-segment elevation acute coronary syndromes has been shown to improve outcomes in most (but not all) recent studies. The optimal timing of intervention has not been determined. Should patients be triaged, as with primary angioplasty for ST-segment elevation, and have a door-to- balloon time of <90 minutes, or should "passivation" of the plaque with intensive antithrombotic therapy be administered for a period of perhaps 12 to 24 hours before angioplasty? In this issue of Circulation, Ryan et al report findings from the CRUSADE Registry, where they compared outcomes of patients presenting on weekends, who experienced a delay to angiography of 46.3 hours, to patients presenting during the week, who experienced a delay to angiography of 23.4 hours. Increased delay was not associated with adverse outcomes. Thus, increasing access to invasive therapy on weekends across the community may not improve population outcomes. See p 3049.

	AMBIENT AIR POLLUTION IS ASSOCIATED WITH INCREASED RISK OF HOSPITAL CARDIAC READMISSIONS OF MYOCARDIAL INFARCTION SURVIVORS IN FIVE EUROPEAN CITIES, by von Klot et al.

 
Air pollution is increasingly recognized as a risk factor for cardiovascular events. In a European study, investigators determined the risk of ambient nitrogen dioxide, carbon monoxide, ozone, and mass of particles <10 µm on the risk of recurrent events in individuals who had survived an acute myocardial infarction. The study sample included 22 006 patients from Augsburg, Barcelona, Helsinki, Rome, and Stockholm from 1992 to 2000. The authors report how daily pollution levels affect risk of cardiac readmissions. See p 3073.

	CONTINUOUS AORTIC FLOW AUGMENTATION: A PILOT STUDY OF HEMODYNAMIC AND RENAL RESPONSES TO A NOVEL PERCUTANEOUS INTERVENTION IN DECOMPENSATED HEART FAILURE, by Konstam et al.

 
Despite therapy with inotropic and vasodilator agents, some patients continue to have left ventricular failure . . . [Full Text of this Article]

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