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(Circulation. 2005;112:3211.)
© 2005 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	ANTICOAGULATION THERAPY IN ATRIAL FIBRILLATION IN COMBINATION WITH ACUTE MYOCARDIAL INFARCTION INFLUENCES LONG-TERM OUTCOME: A PROSPECTIVE COHORT STUDY FROM THE REGISTER OF INFORMATION AND KNOWLEDGE ABOUT SWEDISH HEART INTENSIVE CARE ADMISSIONS (RIKS-HIA), by Stenestrand et al.

 
Atrial fibrillation (AF) is a common arrhythmia after myocardial infarction (MI). Because of the widespread use of aspirin in patients recovering from MI and the increasing use of clopidogrel when a stent is implanted, it is useful to have information on the safety of the combination of aspirin, clopidogrel, and warfarin in patients with AF after MI. Investigators in Sweden report in this issue a prospective cohort study from a registry of intensive care unit admissions. The use of oral anticoagulants in patients with AF was associated with a significant reduction in 1-year mortality and was superior to antiplatelet therapy alone. An accompanying editorial (see p 3212) places this important report in perspective alongside the ACC/AHA Guidelines on management of patients with STEMI and adds support for the use of dual antiplatelet therapy in combination with oral anticoagulation in patients with AF after MI. See p 3225.

	DIETARY -LINOLENIC ACID INTAKE AND RISK OF SUDDEN CARDIAC DEATH AND CORONARY HEART DISEASE, by Albert et al.

 
The majority of women who die suddenly do not have an antecedent history of heart disease. Dietary interventions that are suitable for use in large populations offer potential means to reduce these deaths. Intake of long-chain n-3 fatty acids found in fish have been associated with reduced sudden death. The intermediate-chain n-3 fatty acid a-linolenic acid (ALA), which is found in plants, has antiarrhythmic effects in animal models, and a small portion is converted to long-chain n-3 fatty acids. The impact of ALA intake on cardiovascular outcomes was investigated in 76 763 women enrolled in the Nurses’ Health Study. Increasing ALA intake . . . [Full Text of this Article]

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