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(Circulation. 2005;112:1081.)
© 2005 American Heart Association, Inc.

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An extract of the first 250 words of the full text is provided, because this article has no abstract.

	CCL2 POLYMORPHISMS ARE ASSOCIATED WITH SERUM MONOCYTE CHEMOATTRACTANT PROTEIN-1 LEVELS AND MYOCARDIAL INFARCTION IN THE FRAMINGHAM HEART STUDY, by McDermott et al.

 
Chemokines are chemoattractants that help direct leukocytes from circulating blood to sites of inflammation. Previous animal studies suggest that the chemokine monocyte chemotactic protein-1 (MCP-1) plays an early and critical role in the pathogenesis of atherosclerosis. Based on analysis of the Framingham Offspring Study cohort, McDermott and colleagues now report that individuals with a specific genetic variant in the MCP-1 gene have higher serum levels of MCP-1 and are twice as likely to have had a myocardial infarction (odds ratio 2.0). These findings provide strong support for the importance of MCP-1 in the development and clinical expression of atherosclerosis in humans and suggest that MCP-1 might be a therapeutic target. See p 1113.

	ANEMIA AND CHANGE IN HEMOGLOBIN OVER TIME RELATED TO MORTALITY AND MORBIDITY IN PATIENTS WITH CHRONIC HEART FAILURE: RESULTS FROM VAL-HEFT, by Anand et al.

 
Cardiovascular function in anemia has been studied extensively in humans as well as in experimental animals. In severe chronic anemia, cardiac output is increased and vascular resistance is decreased, setting the basis for a state of hyperdynamic circulation, and eventually, "high-output failure." Anemia may exacerbate preexisting heart failure, and it has been shown that it is associated with worse symptoms, increased mortality rate, and increased hospitalization rate in patients with congestive heart failure. In their study, Anand et al investigated the prognostic significance not only of the hemoglobin level but also of changes in hemoglobin level over time. They retrospectively analyzed more than 5000 patients who participated in the Val-HeFT trial and followed up for 3 years. They confirmed that lower hemoglobin levels are associated with increased risk of morbidity and mortality and demonstrated that hemoglobin . . . [Full Text of this Article]

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