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(Circulation. 2006;113:1549.)
© 2006 American Heart Association, Inc.

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An extract of the first 250 words of the full text is provided, because this article has no abstract.

	RELATIONSHIP BETWEEN HOMOCYSTEINE AND MORTALITY IN CHRONIC KIDNEY DISEASE, by Menon et al.

 
Prior studies relating plasma homocysteine to the risk of cardiovascular disease in the general population have yielded inconsistent results. Reduced glomerular filtration rate (GFR) is a risk factor for cardiovascular disease, and plasma homocysteine is related inversely to GFR. Therefore, the association of plasma homocysteine with cardiovascular disease in some earlier reports may have been confounded by inadequate adjustment for GFR. In this issue of Circulation, Menon and colleagues relate homocysteine levels to all-cause and cardiovascular mortality in patients with stages 3 to 4 chronic kidney disease enrolled in the Modification of Diet in Renal Disease Study who were followed up for a median duration of 10 years. The authors observed that plasma homocysteine levels increased with worsening GFR. In analyses adjusting for GFR (measured by the renal clearance of ¹²⁵I-iothalamate), plasma homocysteine was not associated with all-cause or cardiovascular mortality. These observations suggest that plasma homocysteine may be a marker of severity of kidney disease rather than an independent risk factor in patients with stages 3 to 4 chronic kidney disease. See p 1572.

	IMPACT OF DIABETES MELLITUS ON REGRESSION OF ELECTROCARDIOGRAPHIC LEFT VENTRICULAR HYPERTROPHY AND THE PREDICTION OF OUTCOME DURING ANTIHYPERTENSIVE THERAPY: THE LOSARTAN INTERVENTION FOR ENDPOINT (LIFE) REDUCTION IN HYPERTENSION STUDY, by Okin et al.

 
Research has established that left ventricular hypertrophy (LVH) is associated with excess morbidity and mortality. Moreover, recent observational and randomized data support the concept that LVH regression improves prognosis. Whether the benefits of LVH regression are equivalent across various patient subgroups is, however, uncertain. Dr Okin and colleagues examined over 9000 patients with hypertension in the Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension Study, 1195 of whom had diabetes, to understand the . . . [Full Text of this Article]

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