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(Circulation. 2006;113:1921.)
© 2006 American Heart Association, Inc.

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An extract of the first 250 words of the full text is provided, because this article has no abstract.

	NON–TRANSFERRIN-BOUND IRON AND RISK OF CORONARY HEART DISEASE IN POSTMENOPAUSAL WOMEN, by van der A et al.

 
The parallel rise in both body iron stores and vascular risk in women after menopause led to the ‘iron overload‘ theory of coronary heart disease (CHD). Epidemiological studies relating serum ferritin levels to CHD risk have yielded inconsistent results, however. In this issue of Circulation, van der A and colleagues evaluated a community-based sample of postmenopausal women to test the hypothesis that a labile iron component associated with non--transferrin-bound iron (NTBI) might be more suitable for relating to CHD risk. The investigators noted that women in the highest NTBI tertile had a statistically significant 53% lower risk of acute myocardial infarction and a nonsignificant 16% lower risk of CHD compared with those in the lowest tertile in multivariable analyses. Similar results were obtained for serum iron, transferrin saturation, and serum ferritin. These observations do not support the presence of an excess risk of CHD or myocardial infarction in postmenopausal women with relatively higher levels of NTBI or other measures of iron overload. See p 1942.

	STEM CELL MOBILIZATION INDUCED BY SUBCUTANEOUS GRANULOCYTE-COLONY STIMULATING FACTOR TO IMPROVE CARDIAC REGENERATION AFTER ACUTE ST-ELEVATION MYOCARDIAL INFARCTION: RESULT OF THE DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STEM CELLS IN MYOCARDIAL INFACTION (STEMMI) TRIAL, by Ripa et al.

 
Percutaneous coronary revascularization procedures restore coronary flow quickly in patients with acute ST-elevation myocardial infarction, and yet there is often some degree of myocardial necrosis resulting in left ventricular dysfunction. To prevent adverse ventricular remodeling, efforts have been devoted to determining the therapeutic efficacy of bone-marrow–derived stem cells in preserving ventricular function. These cells have been isolated ex vivo and infused into the coronary artery or have been stimulated to exit the bone marrow to home to sites of myocardial injury by the . . . [Full Text of this Article]

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