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(Circulation. 2006;113:2861.)
© 2006 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	DUAL-CHAMBER VERSUS SINGLE-CHAMBER DETECTION ENHANCEMENTS FOR IMPLANTABLE DEFIBRILLATOR RHYTHM DIAGNOSIS: THE DETECT SUPRAVENTRICULAR TACHYCARDIA STUDY, by Friedman et al.

 
Inappropriate shocks due to supraventricular tachycardias (SVT) can adversely affect quality of life in patients with implantable cardioverter defibrillators (ICDs). Incorporation of atrial sensing into an ICD algorithm for arrhythmia identification was compared to ventricular sensing alone in a 400-patient randomized trial. SVTs were common in ICD recipients, accounting for more than 40% of arrhythmia episodes and occurring in more than 30% of patients. Atrial sensing did reduce inappropriate ICD classification of SVT as ventricular tachycardia (VT), but more than 30% of SVTs were still misclassified as VT. Inappropriate shocks were not reduced because of differences in programming of antitachycardia pacing among groups. These findings by Friedman et al show that atrial sensing can improve SVT detection, but also support appropriate programming of antitachycardia pacing to avoid ICD shocks. Dual chamber ICDs are a reasonable consideration for patients who have VTs with rates that may overlap with SVTs, even if the atrial lead is not required for pacing. See p 2871.

	RESIDUAL ARACHIDONIC ACID-INDUCED PLATELET ACTIVATION VIA AN ADENOSINE DIPHOSPHATE–DEPENDENT BUT CYCLOOXYGENASE-1– AND CYCLOOXYGENASE-2–INDEPENDENT PATHWAY: A 700-PATIENT STUDY OF ASPIRIN RESISTANCE, by Frelinger et al.

 
The absolute risk of recurrent vascular events among patients treated with aspirin remains relatively high and has lead to a concept known as "aspirin resistance." Aspirin resistance has been defined as a clinical entity and by altered biomarkers/enhanced platelet function testing. The mechanism for aspirin resistance remains uncertain, however, and is likely multifactorial. In this issue of Circulation, Frelinger and colleagues study 700 patients treated with aspirin who were undergoing cardiac catheterization. They report that aspirin noncompliance or underdosing was a rare event, and that residual platelet . . . [Full Text of this Article]

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