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(Circulation. 2006;113:597.)
© 2006 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	PATIENTS WITH ACUTE CORONARY SYNDROME SHOW OLIGOCLONAL T-CELL RECRUITMENT WITHIN UNSTABLE PLAQUE: EVIDENCE FOR A LOCAL, INTRACORONARY IMMUNOLOGIC MECHANISM, by De Palma et al.

 
Do immune cells influence the stability of atherosclerotic plaques and contribute to myocardial infarction? In this issue of Circulation, De Palma and colleagues address this question by studying whether immune-driven T-lymphocyte recruitment occurs in unstable plaque of patients with acute coronary syndromes. By examining blood and coronary plaques obtained by atherectomy, the authors compared the T-cells in patients with either unstable or chronic stable angina. They report that unstable plaques have markedly increased T-cell infiltration and that this observation did not require a systemic immunologic activation. These findings demonstrate the complex inflammatory response that occurs in unstable coronary plaque and suggest potential new targets for intervention and prevention. See p 640.

	PROGNOSTIC VALUE OF AORTIC PULSE WAVE VELOCITY AS INDEX OF ARTERIAL STIFFNESS IN THE GENERAL POPULATION, by Willum Hansen et al.

 
As part of the aging process, the aorta stiffens, and the forward pulse wave travels faster with resultant higher systolic and lower diastolic blood pressure. The aortic pulse wave velocity (APWV) is a measure of central arterial stiffness and can be measured easily at the bedside by recording the arterial wave simultaneously at the left common carotid and femoral arteries. This study of 1678 individuals from the general Danish population evaluated the prognostic value of APWV. Over a median follow-up of 9.4 years, 154 cardiovascular events occurred, and higher APWV was associated with a greater incidence of cardiovascular events after adjusting for other risk factors. This study adds to the previous literature on the utility of APWV in patients with hypertension, diabetes, and end-stage renal disease and elderly hospitalized patients; it also provides important new information about . . . [Full Text of this Article]

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