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(Circulation. 2006;114:1133.)
© 2006 American Heart Association, Inc.
Issue Highlights
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
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FAMILIAL SUDDEN DEATH IS AN IMPORTANT RISK FACTOR FOR PRIMARY VENTRICULAR FIBRILLATION: A CASE-CONTROL STUDY IN ACUTE MYOCARDIAL INFARCTION PATIENTS, by Dekker et al. |
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and
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HOW SUDDEN IS SUDDEN CARDIAC DEATH? by Müller et al. |
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Sudden death is most commonly due to coronary artery disease in Western nations, but approximately half occur in patients who either do not have recognized heart disease or have a low risk profile. Two studies in this issue provide the basis for potential strategies to improve sudden death prevention in this population. Studying patients with acute myocardial infarction, Dekker et al found that ventricular fibrillation was associated with a family history of sudden death, supporting a genetic susceptibility to ventricular fibrillation during ischemia. Müller and colleagues used emergency teams responding to cardiac arrest victims to obtain interviews from bystanders. They found that cardiac arrest was often preceded by a substantial period of symptoms. These studies emphasize the potential importance of educating populations to the significance of their family history, and recognizing and responding to symptoms of heart disease as a strategy to reduce sudden cardiac death. See p 1140 and 1146.
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IDENTIFICATION OF THE OXIDIZED LOW-DENSITY LIPOPROTEIN SCAVENGER RECEPTOR CD36 IN PLASMA: A NOVEL MARKER OF INSULIN RESISTANCE, by Handberg et al. |
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The macrophage scavenger receptor CD36 promotes the uptake of oxidized low-density lipoprotein, foam cell formation, and atherosclerosis. Insulin resistance is also associated with increased expression of macrophage CD36. In this issue of Circulation, Handberg and colleagues have identified for the first time a soluble form of CD36 in plasma that also appears to be a marker of metabolic syndrome. Similar to other soluble receptors, such as soluble intercellular adhesion molecule-1 or P-selectin, the authors propose that soluble CD36 might represent a potential surrogate marker of atherosclerosis. See p 1169.
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5-METHYLTETRAHYDROFOLATE RAPIDLY IMPROVES ENDOTHELIAL FUNCTION AND DECREASES SUPEROXIDE PRODUCTION IN HUMAN VESSELS: EFFECTS ON VASCULAR TETRAHYDROBIOPTERIN AVAILABILITY AND ENDOTHELIAL NITRIC OXIDE SYNTHASE COUPLING, by Antoniades et al. |
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It has become increasingly clear that
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