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(Circulation. 2006;114:1343.)
© 2006 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	LOCALIZATION OF NA+ CHANNEL ISOFORMS AT THE ATRIOVENTRICULAR JUNCTION AND ATRIOVENTRICULAR NODE IN THE RAT, by Yoo et al.

 
The anatomical structures, histological architecture, and electrical correlation of atrioventricular nodal function have been an area of research for over 100 years. In this issue of Circulation, Yoo and colleagues have elegantly demonstrated molecular labeling of ion channel subtypes in discrete areas of the atrioventricular conducting system in a rat model. Using immunohistochemistry techniques, they labeled several sodium channel isoform antibodies and marker proteins to molecularly illustrate the complex nature of this critical region. The authors demonstrate areas with functionally distinct cell types with electrophysiological heterogeneity, which is important clinically for understanding the development of variable conduction, dual AV nodal physiology, and reentry. See p 1360.

	SEX DIFFERENCES IN MAJOR BLEEDING WITH GLYCOPROTEIN IIB/IIIA INHIBITORS: RESULTS FROM THE CRUSADE (CAN RAPID RISK STRATIFICATION OF UNSTABLE ANGINA PATIENTS SUPPRESS ADVERSE OUTCOMES WITH EARLY IMPLEMENTATION OF THE ACC/AHA GUIDELINES) INITIATIVE, by Alexander et al.

 
Randomized placebo-controlled clinical trials have demonstrated the efficacy of glycoprotein IIb/IIIa inhibitors in reducing the risk of death or myocardial infarction when administered to patients with non–ST-segment elevation acute coronary syndrome. Women have a greater predilection for bleeding, the major risk of this important therapy. In this study by Alexander et al, the real world experience from 400 hospitals participating in the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines) initiative registry is used to confirm a 2-fold higher rate of major bleeding in women compared with men with the use of glycoprotein IIb/IIIa inhibitors. Approximately a quarter of this excess bleeding can be attributed to excess dosing of women. Other important caveats about glycoprotein IIb/IIIa inhibitors use are well delineated in this clinically important article. See p 1380.

	BLOOD LEAD BELOW 0.48 µmol/L (10 µg/dL) AND MORTALITY AMONG US ADULTS, by Menke et al.

 
High . . . [Full Text of this Article]

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