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(Circulation. 2006;114:183.)
© 2006 American Heart Association, Inc.

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An extract of the first 250 words of the full text is provided, because this article has no abstract.

	PLASMA PHOSPHOLIPID TRANS FATTY ACIDS, FATAL ISCHEMIC HEART DISEASE, AND SUDDEN CARDIAC DEATH IN OLDER ADULTS: THE CARDIOVASCULAR HEALTH STUDY, by Lemaitre et al.

 
Higher dietary consumption of trans fatty acids has been associated with elevated risk of coronary heart disease. Data are limited, however, regarding variation in coronary risk according to the type of trans fatty acid, eg, trans-isomers of oleic acid (trans-18:1) versus trans-isomers of linoleic acid (trans-18:2). In this issue of Circulation, Lemaitre and colleagues conducted a nested case-control study using data from elderly participants in the Cardiovascular Health Study. The investigators compared plasma trans-18:1 and trans-18:2 levels (collected 3 years before occurrence of events) in 214 individuals (cases) with fatal coronary heart disease with plasma levels of these trans fatty acids in 214 matched controls. They report that higher plasma trans-18:2 levels were associated with greater risk of fatal ischemic heart disease and sudden cardiac death in multivariable analyses that adjusted for clinical and lifestyle risk factors including plasma levels of n-3 polyunsaturated fatty acids. In contrast, higher levels of trans-18:1 were associated with lower risk. These observations suggest that different types of trans-isomers in the diet may influence coronary risk differentially. If confirmed, these findings suggest that current efforts at decreasing trans fatty acid intake in foods should take into consideration their trans-18:2 content. See p 209.

	PREVALENCE, CLINICAL PROFILE, AND SIGNIFICANCE OF LEFT VENTRICULAR REMODELING IN THE END-STAGE PHASE OF HYPERTROPHIC CARDIOMYOPATHY, by Harris et al.

 
A minority of patients with hypertrophic cardiomyopathy (HCM) enter a phase known as "end-stage," thought to be represented by systolic dysfunction, left ventricular dilation, and thinning of previously hypertrophied walls. In this issue of Circulation, Harris and . . . [Full Text of this Article]

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