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(Circulation. 2006;114:359.)
© 2006 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	INCREASED CARDIAC ADENYLYL CYCLASE EXPRESSION IS ASSOCIATED WITH INCREASED SURVIVAL AFTER MYOCARDIAL INFARCTION, by Takahashi et al.

 
This mouse study will, as Takahashi and colleagues point out, appear to be counter-intuitive in the light of generally accepted clinical data that ß-blockade lessens adverse myocardial infarction–associated events, mechanistically by decreased formation of the second messenger, cyclic adenosine monophosphate (cAMP). This model had cardiac-directed overexpression of adenylyl cyclase, potentially increasing formation of cAMP, and thus expected to worsen experimental myocardial infarction. In reality, mouse mortality rate decreased, left ventricular dilation lessened, and the ejection fraction rose. To explain these unexpected data, the authors point out that (1) left ventricular remodeling was improved and (2) there was increased sensitivity to calcium of the calcium-uptake pump of the sarcoplasmic reticulum, thereby improving calcium cycling and contractile function. According to the view that there is subcellular compartmentation of cAMP (see editorial by Leineweber et al, p 365), there might be different functional end results according to exactly where and how cAMP is formed and broken down. Theoretically, combined ß-blockade and inhibitors of cAMP breakdown might be clinically tested in very large infarcts. See p 388.

	DELETION OF P47phox ATTENUATES ANGIOTENSIN II–INDUCED ABDOMINAL AORTIC ANEURYSM FORMATION IN APOLIPOPROTEIN E–DEFICIENT MICE, by Thomas et al.

 
The role of oxidative stress in vascular pathology is slowly becoming clearer. In this issue of Circulation, Thomas and colleagues report on the role of nicotinamide adenine dinucleotide phosphate oxidase in the formation of aortic aneurysms in a mouse model. At one time, the nicotinamide adenine dinucleotide phosphate oxidase enzyme was thought limited to neutrophils and its function restricted to host defense. As this important article shows, this enzyme system is now recognized as an . . . [Full Text of this Article]

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