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(Circulation. 2006;114:753.)
© 2006 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	RISK OF THROMBOEMBOLIC EVENTS AFTER PERCUTANEOUS LEFT ATRIAL RADIOFREQUENCY ABLATION OF ATRIAL FIBRILLATION, by Oral et al.

 
In patients with atrial fibrillation (AF), thromboembolism and the need for anticoagulation influence the risks and benefits of catheter ablation for maintaining sinus rhythm. Ablation has a risk of thromboembolism. After a successful procedure, withdrawal of anticoagulation would be attractive to many patients, but there are limited data on the safety of this approach. Oral and colleagues examined these issues in a 755 consecutive patients with AF. They observed a 1.1% risk of thromboembolism during the first few weeks after catheter ablation. After >3 months, warfarin was discontinued in selected low-risk patients. This low-risk group did not experience thromboembolic events during follow-up. These findings provide an estimate of early thromboembolism risk and support withdrawal of anticoagulation in selected low-risk patients who are in sinus rhythm late after AF ablation. Further data are needed addressing warfarin withdrawal in higher-risk groups who undergo a successful ablation procedure. See p 759.

	ADVERSE IMPACT OF BLEEDING ON PROGNOSIS IN PATIENTS WITH ACUTE CORONARY SYNDROMES, by Eikelboom et al.

 
Although great progress has been made in the treatment of patients with acute coronary syndromes, many of the commonly used pharmacological and interventional treatments are associated with increased risk of bleeding. In this issue of Circulation, Eikelboom and colleagues study 34 146 patients from the Organization to Assess Ischemic Syndromes (OASIS) and Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) studies to determine if bleeding was associated with adverse clinical outcome. They report that in patients with acute coronary syndromes without persistent ST-segment elevation, there was a strong association between bleeding and death. Although bleeding is typically considered a . . . [Full Text of this Article]

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