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(Circulation. 2007;115:1334-1335.)
© 2007 American Heart Association, Inc.

Editorial

Dysglycemia and Heart Failure Hospitalization

What Is the Link?

Mark C. Petrie, MB, ChB, MRCP; John J.V. McMurray, MD, FRCP

From the Department of Cardiology, Glasgow Royal Infirmary (M.P.), and Department of Cardiology, Western Infirmary (J.J.V.M.), Glasgow, UK.

Correspondence to Professor John J.V. McMurray, Department of Cardiology, Western Infirmary, Glasgow, G11 6NT. E-mail j.mcmurray@bio.gla.ac.uk

Key Words: Editorials • diabetes mellitus • glucose • heart failure • risk factors

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Large epidemiological studies, including the Framingham Heart Study, the National Health and Nutrition Examination Survey, and the Cardiovascular Health Study, have shown that diabetes mellitus is an independent risk factor for the development of heart failure.^1–3 Overall, the risk is approximately doubled, but the relative increase may be greater in younger compared with older individuals (and in younger women compared with younger men).^1–9 In diabetic individuals, the risk of developing heart failure is greatest in those with an elevated body mass index, poor glycemic control (as indicated by hemoglobin A_1c level), nephropathy, retinopathy, and coronary heart disease.^1–9

Article p 1371

In this issue of Circulation, Held and colleagues¹⁰ have shown that the association between dysglycemia and heart failure extends beyond diabetes mellitus. In a clinical trial cohort of 31 546 subjects with arterial disease, diabetes with end-organ damage, or both who were followed up for a mean of 2.4 years, these investigators found that elevated fasting plasma glucose was an independent predictor of hospitalization for heart failure even in nondiabetic individuals (but unfortunately did not report other cardiovascular outcomes for comparison). These observations support 2 earlier studies. In an investigation of 20 810 nondiabetic patients receiving care in Veterans Affairs medical centers, Nielson and Lange¹¹ found that higher morning glucose was independently associated with a linear increase in risk of incident heart failure (clinic diagnosis or admission). Ingelsson and colleagues,¹² in a study of 1187 Swedish men 70 years of age, showed that 2-hour glucose during an oral glucose . . . [Full Text of this Article]

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