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(Circulation. 2007;115:1969.)
© 2007 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	OPTIMAL TREATMENT OF OBESITY-RELATED HYPERTENSION: THE HYPERTENSION-OBESITY-SIBUTRAMINE (HOS) STUDY, by Scholze et al.

 
This article by Scholze and colleagues provides much-needed guidance on how to deal with the obese patient with mild hypertension (147/93 mm Hg on randomization). The entry point is the use of the weight-reducing drug sibutramine, which achieved weight loss at the cost of a small increase in 24-hour diastolic blood pressure. To control the blood pressure and to annul this increase, 3 combination antihypertensive therapies were used, 2 of them a calcium channel blocker and an angiotensin-converting enzyme inhibitor, and the third a ß-blocker plus diuretic combination. Sibutramine led to weight loss and improved glucose tolerance. These benefits were abrogated in the cohort treated by the ß-blocker-diuretic, as compared with both calcium channel blocker–angiotensin-converting enzyme inhibitor regimes. Triglyceride levels were reduced with sibutramine but not with placebo. Thus, when treating overweight hypertensive patients by sibutramine, blood pressure reduction by a calcium channel blocker–angiotensin-converting enzyme inhibitor regimen is preferred to a ß-blocker-diuretic regimen. See p 1991.

	INFARCT TISSUE HETEROGENEITY BY MAGNETIC RESONANCE IMAGING IDENTIFIES ENHANCED CARDIAC ARRHYTHMIA SUSCEPTIBILITY IN PATIENTS WITH LEFT VENTRICULAR DYSFUNCTION, by Schmidt et al.

 
In recent years, the ability to define carefully the presence, extent, and transmurality of infarct has been strongly validated using noninvasive cardiac magnetic resonance (CMR) imaging. More recently in Circulation, investigators began to explore the ability of CMR to define a border zone surrounding an infarct, likely representing an admixture of viable and infarcted tissue, showing that the presence of such a border zone was associated with an adverse prognosis. Those data suggested the possibility that the border zone represents a milieu for arrhythmia generation. In this issue of Circulation, Schmidt . . . [Full Text of this Article]

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