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(Circulation. 2007;115:2247.)
© 2007 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	DIRECT INTRAMYOCARDIAL BUT NOT INTRACORONARY INJECTION OF BONE MARROW CELLS INDUCES VENTRICULAR ARRHYTHMIAS IN A RAT CHRONIC ISCHEMIC HEART FAILURE MODEL, by Fukushima et al.

 
Cell therapies directed at the damaged ventricle hold promise for improving ventricular function but with potential proarrhythmic electrophysiological effects. Fukushima and colleagues assessed the effects of bone marrow–derived stem cells administered by direct intraventricular injection or retrogradely via injection into the coronary venous system 3 weeks after myocardial infarction in rats. The 2 routes of delivery produced similarly small amounts of donor cells persisting in the myocardium and a similar improvement in LV ejection fraction. ECG telemetry revealed spontaneous ventricular arrhythmias that were prominent for the first 2 weeks after intramyocardial injection but not after intracoronary injection. Further examination showed inflammatory cell clusters after intramyocardial injection but not after intracoronary injection. Thus, the route of delivery influenced short-term arrhythmias independent of the effect on ventricular function. The findings emphasize the potential importance of the route of delivery as a determinant of adverse effects that will need to be considered in human trials. See p 2254.

	RANDOMIZED TRIAL COMPARING SAME-DAY DISCHARGE WITH OVERNIGHT HOSPITAL STAY AFTER PERCUTANEOUS CORONARY INTERVENTION: RESULTS OF THE ELECTIVE PCI IN OUTPATIENT STUDY (EPOS), by Heyde et al.

 
Patients who undergo percutaneous coronary interventions in the United States are routinely hospitalized overnight for observation to facilitate monitoring for the occurrence of any major complications. With improvements in the procedure, particularly the widespread use of stents, the likelihood of complications has fallen dramatically. The discharge of a patient who has had a successful procedure and is stable would improve patient satisfaction and reduce procedure-related costs. The study reported by Heyde et al in this issue of Circulation was a randomized trial of same-day discharge or overnight stay in 800 consecutive patients scheduled for . . . [Full Text of this Article]

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