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(Circulation. 2007;115:3039.)
© 2007 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	LONG-TERM PROGNOSTIC VALUE OF NEOPTERIN: A NOVEL MARKER OF MONOCYTE ACTIVATION IN PATIENTS WITH ACUTE CORONARY SYNDROME, by Ray et al.

 
Inflammatory processes are major contributors to atherothrombosis. As such, investigators have maintained intense interest in identifying noninvasive tools to detect underlying inflammation that may (1) enhance risk assessment, (2) direct specific interventions to modify risk, and (3) provide a means by which to monitor the response to therapy. Neopterin, a soluble biomarker produced by activated monocytes, has shown promise as a prognostic indicator in small clinical studies of patients with acute coronary syndromes. Ray and colleagues assessed the association between neopterin and clinical outcomes in 4000 patients with ACS and showed an adjusted 86% higher relative risk of death in patients with a neopterin concentration in the highest quartile (12.11 nmol/L). Intensive statin therapy significantly attenuated the risk associated with an elevated baseline concentration of neopterin. These findings support continued investigation of neopterin as a potential tool to target and monitor the success of preventive therapies with antiinflammatory actions. See p 3071.

	SUPERIOR CARDIOVASCULAR EFFECT OF AEROBIC INTERVAL TRAINING VERSUS MODERATE CONTINUOUS TRAINING IN HEART FAILURE PATIENTS: A RANDOMIZED STUDY, by Wisløff et al.

 
and

	EXERCISE TRAINING NORMALIZES SYMPATHETIC OUTFLOW BY CENTRAL ANTIOXIDANT MECHANISMS IN RABBITS WITH PACING-INDUCED CHRONIC HEART FAILURE, by Gao et al.

 
Exercise training among patients with heart failure has been shown to have beneficial effects beyond improvements in exercise capacity. The mechanisms by which these favorable effects occur are not yet fully understood, and the optimal training regimen that should be prescribed to attain these benefits is not known. In this issue of Circulation, 2 related papers are presented. Gao and colleagues report interesting findings from study of a rabbit model used to evaluate whether the observed favorable alterations in sympathoexcitation are attributable to antioxidative changes that occur in the central nervous system. In a . . . [Full Text of this Article]

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