This Article Free upon publication Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Related Collections Related Articles

(Circulation. 2007;115:3139.)
© 2007 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	EVALUATION OF DOSE-RELATED EFFECTS OF ASPIRIN ON PLATELET FUNCTION: RESULTS FROM THE ASPIRIN-INDUCED PLATELET EFFECT (ASPECT) STUDY, by Gurbel et al.

 
Although there have been many studies examining the effect of aspirin on platelet function, most have limitations in study design and are associative. In this issue of Circulation, Gurbel and colleagues report a double-blind, double-crossover investigation of 125 stable outpatients with coronary disease who received 3 different doses of aspirin for 4 weeks over a 12-week period. A broad panel of cyclooxygenase-1–dependent and –independent platelet function assays were examined. The authors found that, while aspirin consistently blocked arachidonic acid–induced function, the other platelet function tests demonstrated greater estimates of resistance. These results suggest that aspirin’s non–cyclooxygenase-1–dependent effects may contribute to the variability in aspirin response. See p 3156.

	SUPPRESSION OF CENTRAL SLEEP APNEA BY CONTINUOUS POSITIVE AIRWAY PRESSURE AND TRANSPLANT-FREE SURVIVAL IN HEART FAILURE: A POST HOC ANALYSIS OF THE CANADIAN CONTINUOUS POSITIVE AIRWAY PRESSURE FOR PATIENTS WITH CENTRAL SLEEP APNEA AND HEART FAILURE TRIAL (CANPAP), by Arzt et al.

 
The primary analysis of the Canadian Continuous Positive Airway Pressure (CPAP) for Patients With Central Sleep Apnea and Heart Failure Trial (CANPAP) showed no benefit on heart transplant–free survival; however, many patients in the trial failed to achieve the target goal of an apnea-hypopnea index <15. In a post hoc analysis, it was found that CPAP-treated patients who obtained a reduction in apnea-hypopnea index to <15 showed improvements in both left ventricular ejection fraction and transplant-free survival versus control patients. In contrast, CPAP-treated patients who did not achieve an apnea-hypopnea index of <15 did not have improvements in either left ventricular ejection fraction or survival. These findings suggest that CPAP therapy sufficient to reduce apnea-hypopnea index may improve left ventricular function and survival. See p 3173.

	CARDIAC ANGIOGRAPHY IN RENALLY IMPAIRED PATIENTS (CARE) STUDY: A RANDOMIZED DOUBLE-BLIND TRIAL OF CONTRAST-INDUCED NEPHROPATHY IN PATIENTS WITH CHRONIC KIDNEY DISEASE, by Solomon et al.

 
Contrast induced nephropathy (CIN) is an uncommon complication of angiography, but it is . . . [Full Text of this Article]

Related Articles:

Anaphylaxis and Recurrent Hydatid Disease

Ignacio Cruz-Gonzalez, Francisco Martin-Herrero, Jose M. Gonzalez-Santos, Jose A. Gutierrez-Diez, Maria Sanchez-Ledesma, and Andrew O. Maree
Circulation 2007 115: e643-e645. [Extract] [Full Text]

The Metamorphosis of the Thrombus After Thrombolytic Therapy

Lukasz Chrzanowski, Marcin Fiutowski, Maria Krzeminska-Pakula, Karina Wierzbowska-Drabik, Jaroslaw Drozdz, Bartlomiej Wozniakowski, Ludomir Stefanczyk, and Jaroslaw D. Kasprzak
Circulation 2007 115: e646-e647. [Extract] [Full Text]

Letter by Krötz et al Regarding Article, "Improvement of Peripheral Endothelial Dysfunction by Protein Tyrosine Phosphatase Inhibitors in Heart Failure"

Florian Krötz, Hae-Young Sohn, and Hanna Mannell
Circulation 2007 115: e648. [Extract] [Full Text]

Cardiac Angiography in Renally Impaired Patients (CARE) Study: A Randomized Double-Blind Trial of Contrast-Induced Nephropathy in Patients With Chronic Kidney Disease

Richard J. Solomon, Madhu K. Natarajan, Serge Doucet, Samin K. Sharma, Cezar S. Staniloae, Richard E. Katholi, Joseph L. Gelormini, Marino Labinaz, Abel E. Moreyra, and the Investigators of the CARE Study
Circulation 2007 115: 3189-3196. [Abstract] [Full Text]

Evaluation of Dose-Related Effects of Aspirin on Platelet Function: Results From the Aspirin-Induced Platelet Effect (ASPECT) Study

Paul A. Gurbel, Kevin P. Bliden, Joseph DiChiara, Justin Newcomer, Willy Weng, Nagaraj K. Neerchal, Tania Gesheff, Srivasavi K. Chaganti, Amena Etherington, and Udaya S. Tantry
Circulation 2007 115: 3156-3164. [Abstract] [Full Text]

Suppression of Central Sleep Apnea by Continuous Positive Airway Pressure and Transplant-Free Survival in Heart Failure: A Post Hoc Analysis of the Canadian Continuous Positive Airway Pressure for Patients With Central Sleep Apnea and Heart Failure Trial (CANPAP)

Michael Arzt, John S. Floras, Alexander G. Logan, R. John Kimoff, Frederic Series, Debra Morrison, Kathleen Ferguson, Israel Belenkie, Michael Pfeifer, John Fleetham, Patrick Hanly, Mark Smilovitch, Clodagh Ryan, George Tomlinson, T. Douglas Bradley for the CANPAP Investigators
Circulation 2007 115: 3173-3180. [Abstract] [Full Text]