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(Circulation. 2007;115:287.)
© 2007 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	EARLY OUTCOMES OF TRICUSPID VALVE REPLACEMENT IN YOUNG CHILDREN, by Bartlett et al.

 
Few data on the outcome of tricuspid valve replacement in young children are available to guide decisions. Bartlett and colleagues reviewed the results of tricuspid valve replacement in 97 children younger than age 6 years using the database of the Pediatric Cardiac Care Consortium of 45 centers between 1984 and 2002. The primary outcome was survival to discharge. The most frequent cardiac diagnoses were Ebstein’s anomaly (40%), pulmonary atresia (11%), and tetralogy of Fallot (8%). In-hospital mortality was 26% overall and was highest among infants (64%). Valve thrombosis and heart block requiring a pacemaker were common complications. The high morbidity and mortality of tricuspid valve replacement in young children and especially infants suggests that other surgical options should be considered. See p 319.

	MYOCARDIAL ISCHEMIC MEMORY IMAGING WITH MOLECULAR ECHOCARDIOGRAPHY, by Villanueva et al.

 
Myocardial ischemia that does not result in necrosis may be difficult to diagnose after resolution of the ischemia. Such episodes are associated with endothelial upregulation of leukocyte adhesion molecules. In this issue, Villanueva et al describe the potential of myocardial ischemic memory using contrast echocardiography. Lipid microbubbles were designed to adhere to selectins, and this was tested in a model of inflamed rat cremaster muscle and in a rat model. Twelve rats underwent 15 minutes of left anterior descending coronary artery occlusion and then at 15 minutes and 1 hour following reperfusion, there was greater opacification of the ischemic bed using microbubbles with the selectin ligand. Immunostaining confirmed endothelial P-selectin expression. Although preliminary, the present study raises the potential that this technique may allow the identification . . . [Full Text of this Article]

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