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(Circulation. 2007;115:547.)
© 2007 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	ASSOCIATIONS OF GESTATIONAL AGE AND INTRAUTERINE GROWTH WITH SYSTOLIC BLOOD PRESSURE IN A FAMILY-BASED STUDY OF 386 485 MEN IN 331 089 FAMILIES, by Lawlor et al.

 
Many previous studies have provided support for the fetal origins of disease. Investigators have hypothesized that fetal undernutrition contributes to poor growth and programs individuals for hypertension in later life. Skeptics have raised concerns, however, that studies supporting the developmental origins hypothesis may reflect residual confounding by socioeconomic factors. Lawlor and colleagues took advantage of Swedish birth and military service registries of 386 485 singleton-born men from 331 089 families to study the associations of birth weight and gestational age with subsequent systolic blood pressure at age 17 to 19 years. The investigators report that birth weight was inversely associated with systolic blood pressure; per 1-SD difference in birth weight, there was a –0.21 mm Hg difference in siblings, whereas nonsiblings had –0.12 mm Hg lower systolic blood pressure. They also observed that increasing gestational age was inversely associated with young adult systolic blood pressure. By taking advantage of a large unique sibling data set, the Lawlor et al study suggests that the link between gestational age, lower birth weight, and adult blood pressure does not merely reflect confounding by socioeconomic status. See p 562.

	EFFECTS OF NORMAL BLOOD PRESSURE, PREHYPERTENSION, AND HYPERTENSION ON CORONARY MICROVASCULAR FUNCTION, by Erdogan et al.

 
Coronary flow reserve (CFR) has been shown to be impaired in patients with hypertension. Left ventricular hypertrophy contributes, but other mechanisms likely contribute as well. Prehypertension is also associated with an increased cardiovascular morbidity and mortality. Whether prehypertension is associated with impaired CFR is less well studied. The study by Erdogan et al in this issue of Circulation evaluated CFR using transthoracic Doppler echocardiography . . . [Full Text of this Article]

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