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(Circulation. 2007;115:819.)
© 2007 American Heart Association, Inc.
Issue Highlights
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
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GENDER DIFFERENCES IN HOSPITAL MORTALITY AND USE OF PERCUTANEOUS CORONARY INTERVENTION IN ACUTE MYOCARDIAL INFARCTION: MICROSIMULATION ANALYSIS OF THE 1999 NATIONWIDE FRENCH HOSPITALS DATABASE, by Milcent et al. |
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Early studies that examined the relationship between gender and mortality rates in patients with acute myocardial infarction found that women tend to have significantly higher in-hospital mortality rates as compared with men. This finding has been attributed to older age at time of presentation, smaller body habitus, and greater prevalence of comorbid disease states among women, suggesting that women have higher-risk clinical characteristics compared to men. Furthermore, some studies have suggested that revascularization procedures are used less frequently in women compared with men. At present, the relative contribution of each of these factors to elevated mortality rates in women with acute myocardial infarction remains unclear. In this issue of Circulation, Milcent et al investigated these factors using a national database in France, which includes data from 74 389 patients hospitalized with an acute myocardial infarction. The present study suggests that after adjustment for age, women have higher mortality and lower use of revascularization procedures compared with men. See p 833 (editorial p 823).
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HORMONE THERAPY AND VENOUS THROMBOEMBOLISM AMONG POSTMENOPAUSAL WOMEN: IMPACT OF THE ROUTE OF ESTROGEN ADMINISTRATION AND PROGESTOGENS: THE ESTHER STUDY, by Canonico et al. |
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Use of oral estrogen in postmenopausal women has been found to increase the rate of venous and arterial thrombotic events including venous thromboembolism. Small studies have suggested that route of administration might alter this risk. In the current issue of Circulation, Canonico and colleagues report the results of a multicenter case-control study of postmenopausal women that oral but not transdermal estrogen is associated with an increased risk of venous thromboembolism. They also found that micronised progesterone was safer in terms of thrombotic risk. These
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