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(Circulation. 2007;116:2095.)
© 2007 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	PHYSICAL ACTIVITY AND REDUCED RISK OF CARDIOVASCULAR EVENTS: POTENTIAL MEDIATING MECHANISMS, by Mora et al.

 
A large body of epidemiological data demonstrates that higher levels of physical fitness as well as physically active lifestyles are associated with a lower risk of subsequent cardiovascular events. Many putative mechanisms to explain this association have been proposed, including the effect of exercise on cardiovascular risk factors, inflammation, autonomic tone, and endothelial function. In the largest and most comprehensive study to date, researchers from the Women’s Health Study provide a detailed evaluation of more than 27 000 women to assess the contribution of conventional risk factors and inflammatory/hemostatic biomarkers to lower cardiovascular risk at various graded levels of physical activity. The findings of this study provide important biological insights to the observation that physical activity confers health. See p 2110.

	IMPACT OF THE METABOLIC SYNDROME ON MACROVASCULAR AND MICROVASCULAR OUTCOMES IN TYPE 2 DIABETES MELLITUS: UNITED KINGDOM PROSPECTIVE DIABETES STUDY 78, by Cull et al.

 
The metabolic syndrome is associated with an undisputed increased risk of cardiovascular disease events. However, there are several areas of controversy associated with the syndrome, including which of the 4 diagnostic schemes is most predictive of cardiovascular disease and whether metabolic syndrome adds to risk prediction in individuals with diagnosed type 2 diabetes mellitus. Cull and colleagues followed newly diagnosed patients with type 2 diabetes mellitus from the United Kingdom Prospective Diabetes Study for about 10 years. Regardless of the classification system (Adult Treatment Program III, World Health Organization, International Diabetes Federation, or European Group for the Study of Insulin Resistance), the prevalence of metabolic syndrome was fairly high (ranging for 24% to 61%) and was associated with an increased risk of cardiovascular disease (relative risk 1.19 to . . . [Full Text of this Article]

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