This Article Free upon publication Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Related Collections Related Articles

(Circulation. 2007;116:125.)
© 2007 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	PREVALENCE AND PROGNOSTIC SIGNIFICANCE OF WALL-MOTION ABNORMALITIES IN ADULTS WITHOUT CLINICALLY RECOGNIZED CARDIOVASCULAR DISEASE: THE STRONG HEART STUDY, by Cicala et al.

 
Although it has been established that asymptomatic left ventricular systolic dysfunction predicts worse prognosis, the prognosis of regional-wall motion abnormalities in individuals without known cardiovascular disease has been uncertain. Cicala and colleagues examined the Strong Heart Study, an American Indian population--based cohort, to address the outcome of echocardiographic wall-motion abnormalities in previously undiagnosed cardiovascular disease. They observed that 5% of individuals had segmental and 1.5% had global wall-motion abnormalities by echocardiography. Not surprisingly, participants with segmental wall-motion abnormalities had a higher prevalence of cardiovascular disease risk factors, including diabetes and higher blood pressure, C-reactive protein, creatinine, and albuminuria. In 8 years of follow-up, those with either regional or global wall-motion abnormalities had an adjusted 2- to 3-fold increased risk of cardiovascular events and death. The present study is consistent with many previous studies suggesting that indicators of subclinical disease are associated with worse prognosis. The optimal management of indicators of silent ischemia is controversial and is not addressed by the present study. However, in the absence of data specifically addressing clinically unrecognized cardiovascular disease, strict adherence to guideline-based preventive therapy is indicated with evidence of subclinical disease. See p 143 (editorial p 126).

	FAVORABLE LONG-TERM OUTCOME AFTER DRUG-ELUTING STENT IMPLANTATION IN NONBIFURCATION LESIONS THAT INVOLVE UNPROTECTED LEFT MAIN CORONARY ARTERY: A MULTICENTER REGISTRY, by Chieffo et al.

 
Surgery is the treatment of choice for unprotected left main coronary artery disease, but percutaneous intervention using drug-eluting stents is increasingly being used. Stenting of the ostium or body of the left main coronary artery is technically easier and usually only requires 1 stent; however, the short- and long-term outcome of these patients is not known. . . . [Full Text of this Article]

Related Articles:

Recognizing Unrecognized Risk: The Evolving Role of Ventricular Functional Assessment in Population-Based Studies

David S. Owens and Jonathan F. Plehn
Circulation 2007 116: 126-130. [Extract] [Full Text]

Percutaneous Coronary Intervention of Chronic Total Occlusion With Retrograde Approach: Follow-Up by Cardiac Magnetic Resonance Imaging

Didier Locca, Chiara Bucciarelli-Ducci, Alessio La Manna, and Sanjay Prasad
Circulation 2007 116: e22-e24. [Extract] [Full Text]

Mitochondrial Cardiomyopathy Evaluated With Cardiac Magnetic Resonance

Michio Nakanishi, Masaki Harada, Eiji Tadamura, Hirokazu Kotani, Rika Kawakami, Koichiro Kuwahara, Yasuaki Nakagawa, Satoru Usami, Hideyuki Kinoshita, Masataka Fujiwara, Kiminori Hosoda, Kenji Ueshima, and Kazuwa Nakao
Circulation 2007 116: e25-e26. [Extract] [Full Text]

Letter by Stewart Regarding Articles, "Increasing Use of Cardiopulmonary Resuscitation During Out-of-Hospital Ventricular Fibrillation Arrest: Survival Implications of Guideline Changes" and "Measuring Progress in Resuscitation: It’s Time for a Better Tool"

John A. Stewart
Circulation 2007 116: e27. [Extract] [Full Text]

Oxidant Stress Impairs In Vivo Reendothelialization Capacity of Endothelial Progenitor Cells From Patients With Type 2 Diabetes Mellitus: Restoration by the Peroxisome Proliferator-Activated Receptor- Agonist Rosiglitazone

Sajoscha A. Sorrentino, Ferdinand H. Bahlmann, Christian Besler, Maja Müller, Svenja Schulz, Nina Kirchhoff, Carola Doerries, Tibor Horváth, Anne Limbourg, Florian Limbourg, Danilo Fliser, Hermann Haller, Helmut Drexler, and Ulf Landmesser
Circulation 2007 116: 163-173. [Abstract] [Full Text]

Favorable Long-Term Outcome After Drug-Eluting Stent Implantation in Nonbifurcation Lesions That Involve Unprotected Left Main Coronary Artery: A Multicenter Registry

Alaide Chieffo, Seung J. Park, Marco Valgimigli, Young H. Kim, Joost Daemen, Imad Sheiban, Alessandra Truffa, Matteo Montorfano, Flavio Airoldi, Giuseppe Sangiorgi, Mauro Carlino, Iassen Michev, Cheol W. Lee, Myeong K. Hong, Seong W. Park, Claudio Moretti, Erminio Bonizzoni, Renata Rogacka, Patrick W. Serruys, and Antonio Colombo
Circulation 2007 116: 158-162. [Abstract] [Full Text]