This Article Free upon publication Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Related Collections Related Articles

(Circulation. 2007;116:359.)
© 2007 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	BURDEN AND PROGNOSTIC IMPORTANCE OF SUBCLINICAL CARDIOVASCULAR DISEASE IN OVERWEIGHT AND OBESE INDIVIDUALS, by Ingelsson et al.

 
Subclinical cardiovascular disease can be assessed using several routinely available tests that can measure atherosclerotic burden and target organ damage. The extent of subclinical disease in obesity and its prognostic importance has not been investigated systematically. In this issue of Circulation, Ingelsson and colleagues used data from 5 tests (electrocardiography, echocardiography, carotid ultrasound, ankle-brachial pressure, urinary albumin excretion) performed in the community-based Framingham Heart Study sample. The authors report a higher cross-sectional prevalence of subclinical disease in overweight and obese individuals (compared with those with a normal body mass index), and in those with increased waist circumference compared with those with a normal waist circumference. On prospective follow-up, the risk of overt cardiovascular disease was higher in overweight and obese individuals with evidence of subclinical disease, as compared with individuals without subclinical disease. These data suggest that overweight and obesity are associated with a high prevalence of subclinical disease, which in part contributes to the increased risk of overt cardiovascular disease in individuals with excess adiposity. See p 375.

	PREDICTION OF MODE OF DEATH IN HEART FAILURE: THE SEATTLE HEART FAILURE MODEL, by Mozaffarian et al.

 
Therapeutic strategies to treat symptomatic heart failure are directed toward improving prognosis. Clinicians are very aware that the risk of death and other complications of heart failure vary considerably The Seattle Heart Failure Model incorporates commonly available clinical features, laboratory measurements, and medications used to provide some quantization of this nonhomogeneous risk. In this issue of Circulation, Mozaffarian and colleagues use information from several clinical trials and registries to evaluate the Seattle Heart Failure Model score to assess . . . [Full Text of this Article]

Related Articles:

A Time to be Born and a Time to Die

Lee R. Goldberg and Mariell Jessup
Circulation 2007 116: 360-362. [Extract] [Full Text]

Tissue Plasminogen Activator–Induced Reperfusion Injury After Stroke Revisited

Dirk M. Hermann and Christian M. Matter
Circulation 2007 116: 363-365. [Extract] [Full Text]

Apicoaortic Valve–Containing Conduit in a Patient With Relapsing Prosthetic Endocarditis

Thomas Strecker, Dieter Ropers, Michael Weyand, and Albrecht Reimann
Circulation 2007 116: e88-e89. [Extract] [Full Text]

Isolated Left Ventricular Noncompaction Enhanced by Echocontrast Agent

Chi-Ming Chow, Ki-Dong Lim, Louis Wu, and Howard Leong-Poi
Circulation 2007 116: e90-e91. [Extract] [Full Text]

Letter by O’Rourke Regarding Articles, "Prevalence of Long-QT Syndrome Gene Variants in Sudden Infant Death Syndrome," "Cardiac Sodium Channel Dysfunction in Sudden Infant Death Syndrome," and "Contribution of Long-QT Syndrome Genes to Sudden Infant Death Syndrome: Is It Time to Consider Newborn Electrocardiographic Screening?"

Michael F. O’Rourke
Circulation 2007 116: e92. [Extract] [Full Text]

Burden and Prognostic Importance of Subclinical Cardiovascular Disease in Overweight and Obese Individuals

Erik Ingelsson, Lisa M. Sullivan, Caroline S. Fox, Joanne M. Murabito, Emelia J. Benjamin, Joseph F. Polak, James B. Meigs, Michelle J. Keyes, Christopher J. O’Donnell, Thomas J. Wang, Ralph B. D’Agostino, Philip A. Wolf, and Ramachandran S. Vasan
Circulation 2007 116: 375-384. [Abstract] [Full Text]