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Circulation. 2007;116:879
doi: 10.1161/CIRCULATIONAHA.107.185627
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(Circulation. 2007;116:879.)
© 2007 American Heart Association, Inc.

Issue Highlights


An extract of the first 250 words of the full text is provided, because this article has no abstract.
 


*    INDEPENDENT IMPACT OF GOUT ON MORTALITY AND RISK FOR CORONARY HEART DISEASE, by Choi and Curhan.
 
Gout is the most common inflammatory arthritis in men, yet data on the impact of gout on risk of death and cardiovascular disease are limited. Prior studies have investigated the risks associated with hyperuricemia but have not focused specifically on long-term outcomes in patients with clinical gout. In this issue of Circulation, Choi and Curhan describe prospective data about the impact of gout on risk of death in the >51 000 male participants of the Health Professionals Follow-Up Study. The authors note that over a follow-up period of 12 years, men with gout had a 28% higher risk of death from all causes than men without prior coronary heart disease (CHD) or gout. Among men without preexisting CHD, the increased mortality risk was due to elevated risk of cardiovascular disease deaths, particularly CHD deaths. These associations were independent of established risk factors, including age, body mass index, smoking, family history of myocardial infarction, use of diuretics and aspirin, dietary risk factors, diabetes, hypercholesterolemia, and hypertension. These observational data support aggressive management of cardiovascular risk factors, including hypertension, dyslipidemia, and lifestyle factors, in patients with gout. See p 894 (editorial p 880).


*    SERIAL ANGIOSCOPIC EVIDENCE OF INCOMPLETE NEOINTIMAL COVERAGE AFTER SIROLIMUS-ELUTING STENT IMPLANTATION: COMPARISON WITH BARE-METAL STENTS, by Awata et al.
 
Neointimal coverage after implantation of drug-eluting stents is recognized to be delayed as compared with bare-metal stents. Serial angioscopy allows assessment of neointimal formation and subclinical thrombosis after drug-eluting stent implantation. In the study in this issue by Awata et al, angioscopy was performed serially at 3.6±1.1 months, 10.5±1.5 months, and 21.2±2.2 months after implantation in 17 . . . [Full Text of this Article]


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