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(Circulation. 2008;117:1502-1504.)
© 2008 American Heart Association, Inc.

Editorial

Accessory Atrioventricular Pathways

Getting to the Origins

Siew Yen Ho, PhD, FRCPath, FESC

From Cardiac Morphology, National Heart & Lung Institute, Imperial College London and Royal Brompton Hospital, London, United Kingdom.

Correspondence to Siew Yen Ho, PhD, FRCPath, FESC, Cardiac Morphology, National Heart & Lung Institute, Dovehouse St, London, United Kingdom, SW3 6LY. E-mail yen.ho@imperial.ac.uk

Key Words: Editorials • arrhythmia • morphogenesis • Wolff- Parkinson-White syndrome

An extract of the first 250 words of the full text is provided, because this article has no abstract.

By definition, accessory atrioventricular pathways are aberrant muscle bundles that connect the atrium to a ventricle outside of the regular atrioventricular conduction system. Clinically, they may manifest as substrates for ventricular preexcitation. The first accessory pathway in a patient who suffered from Wolff-Parkinson-White syndrome was described in 1943 by Wood, Wolferth, and Geckler.¹ Shortly after, Öhnell created a reconstruction of an accessory pathway that very elegantly showed the close proximity of the pathway to the fibrous attachment of the mitral valve and its relationship with the sulcus coronarius (Figure, A).² Subsequent histological studies have demonstrated unequivocally that these pathways are the anatomic substrates for the classical Wolff-Parkinson-White variety of preexcitation.

View larger version (46K):   Figure. A, Öhnell’s depiction of an accessory bundle in the left atrioventricular groove.2 Reprinted with permission from Blackwell Publishing. B, Histological section stained with Masson’s trichrome (fibrous tissue in green and myocardium in red) to show an accessory left-sided pathway (arrow) skirting the mitral annulus. C, Histological section showing a broad right-sided accessory pathway (arrow) that is formed by a myocardial pouch extending from the right atrial appendage to the ventricle and ultimately traced to a small right ventricular vein. This pathway is some distance from the fibrous annulus of the tricuspid valve. *Valvar annulus.

Article p 1508

Accessory atrioventricular pathways are found most often in the parietal atrioventricular junctional areas, including the paraseptal areas. They breach the insulation provided by the fibrofatty tissues of the atrioventricular groove (sulcus tissue) and the hingelines (fibrous annulus) of the valves. . . . [Full Text of this Article]