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(Circulation. 2008;117:3055-3056.)
© 2008 American Heart Association, Inc.

Clinical Summaries

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	Obesity, Behavioral Lifestyle Factors, and Risk of Acute Coronary Events

 
Obesity is an important modifiable risk factor for coronary heart disease. However, it is clear that achieving weight loss or preventing weight gain with aging is difficult for most individuals. Whether the high cardiovascular risk associated with obesity is alleviated by physical activity remains controversial; furthermore, little is known about the cardiovascular risk associated with obesity in the context of other behavioral lifestyle factors. In our investigation of the associations of obesity in combination with potentially modifiable behavioral lifestyle factors among 54 783 middle-aged men and women, we found that obesity was strongly associated with the risk of acute coronary syndrome among the physically active and inactive, in nonsmokers and smokers, among those who adhered to a more or less heart-healthy dietary pattern, and in participants with and without a moderate alcohol intake. Body mass index also was associated with acute coronary syndrome in subgroups of important clinical risk factors, suggesting that prevention of obesity is important even in those who adhere to an otherwise healthy lifestyle or who are free of clinical symptoms. Our results further indicated that increasing physical activity level, abstaining from smoking, consuming a more heart-healthy diet, and having a moderate alcohol intake likely result in a lower risk of acute coronary syndrome even in obese individuals. See p 3062.

	Intracellular Protein Aggregation Is a Proximal Trigger of Cardiomyocyte Autophagy

 
Chronic hemodynamic stress such as poorly controlled hypertension induces hypertrophic growth of the heart. This pathological growth response, with time, leads to ventricular dilation, systolic dysfunction, and clinical heart failure, which is a leading cause . . . [Full Text of this Article]

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