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(Circulation. 2008;118:321-322.)
© 2008 American Heart Association, Inc.

Clinical Summaries

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	Comprehensive Canadian Review of the Off-Label Use of Recombinant Activated Factor VII in Cardiac Surgery

 
In this comprehensive review of the use of recombinant activated factor VII in nonhemophiliac patients who underwent cardiac surgery during the period 2003 through 2006 in Canada (n=503), we found that recombinant activated factor VII was used primarily when standard interventions had failed to control blood loss. Moreover, as far as could be determined within the confines of this observational study, we found that recombinant activated factor VII was associated with a reduction in transfusion of blood products and, after adjustment for patients’ underlying risk profile and red blood cell transfusion rate, did not appear to be associated with increased or decreased mortality or major morbidity. Finally, our data also suggested that the effectiveness of the drug may be enhanced if it is given early in the course of refractory blood loss in the setting of adequate amounts of circulating coagulation factors. Adequately powered randomized clinical trials are needed to verify these findings. See p 331.

	-Linolenic Acid and Risk of Nonfatal Acute Myocardial Infarction

 
Long-chain n-3 fatty acids from fish, eicosapentaenoic acid and docosahexaenoic acid, reduce cardiovascular mortality, but availability of fish is limited and probably insufficient to meet worldwide needs. -Linolenic acid, an essential n-3 fatty acid found in vegetable cooking oils such as soybean and canola oils and other products of plant origin could be a viable alternative to fish oils. We determined whether -linolenic acid was associated with risk of nonfatal acute myocardial infarction in 1819 case-control pairs from a population-based study in Costa Rica. Increased dietary -linolenic acid assessed by questionnaire and in . . . [Full Text of this Article]

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