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(Circulation. 2008;118:607-608.)
© 2008 American Heart Association, Inc.

Clinical Summaries

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	Prevention of Ventricular Arrhythmias With Sarcoplasmic Reticulum Ca2+ ATPase Pump Overexpression in a Porcine Model of Ischemia Reperfusion

 
Cardiac arrhythmia is a potentially life-threatening complication of heart failure and ischemic heart disease. In the past, some therapeutic approaches for both of these conditions were associated with an increased risk of arrhythmia and/or sudden cardiac death. Previous work in a variety of animal models has demonstrated that enhancing sarcoplasmic reticulum calcium uptake through expression of the sarcoplasmic reticulum ATPase (SERCA2a) can improve cardiac contractile function, survival, and the energetic state. Here, we demonstrate in a preclinical large animal model that, in contrast to some pharmacological agents that improve inotropy but increase electric instability, SERCA2a expression actually reduces arrhythmia as a result of calcium overload. These findings support the notion that enhancing sarcoplasmic reticulum calcium uptake may hold promise for the prevention and treatment of arrhythmia for reperfusion and heart failure. See p 614.

	Tumor Necrosis Factor- and Mortality in Heart Failure: A Community Study

 
Mortality among patients with heart failure is high. Interest has risen recently in the use of biomarkers to aid in identifying heart failure patients at increased mortality risk. Tumor necrosis factor- (TNF), an inflammatory cytokine, has previously been reported to be elevated in heart failure clinical trial patients with reduced ejection fraction and associated with increased mortality. However, data on patients with preserved EF and those living in the community were lacking. Among community heart failure patients with both preserved and reduced ejection fraction, our study findings indicate that TNF is elevated in 29% of patients and that higher levels are more common in patients with increased comorbidity, including renal insufficiency and anemia. Higher . . . [Full Text of this Article]

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