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(Circulation. 1995;91:2857-2861.)
© 1995 American Heart Association, Inc.

Articles

Meeting Highlights

James J. Ferguson, MD

From the Texas Heart Institute, St Luke's Episcopal Hospital, Baylor College of Medicine, the University of Texas Health Science Center at Houston.

	Introduction

 
The following studies were presented at the 67th Scientific Sessions of the American Heart Association, Dallas, Tex, November 14-17, 1994.

	Intracoronary Irradiation

 
Dr Joseph Wiederman from Columbia University in New York, NY, presented data from a dose-ranging study of radiation therapy after balloon injury in pigs. A total of 30 animals (10 per group) were pretreated with either 2000, 1500, or 1000 cGy of radiation from a ¹⁹²Ir wire at the site of balloon overstretch injury and were compared with a control group of 10 animals who did not receive any radiation before balloon injury. All animals were treated with aspirin and killed at 30 days. A stimulatory effect on neointimal area was noted in the 1000-cGy group, whereas the 1500- and 2000-cGy groups had significantly lower neointimal area and percent area stenosis. The authors concluded that the effect of radiation appears to be dose dependent; the minimal therapeutic dose of radiation was 1500 cGy.

Dr Wiederman also presented data from a controlled long-term follow-up study in which pigs undergoing balloon injury of a proximal coronary segment were pretreated with a 2-cm ribbon of ¹⁹²Ir positioned at the treatment site to deliver 2000 cGy of radiation before balloon injury. All animals received daily oral aspirin and were killed at 180±8 days. The irradiated group (n=11) showed a significant decrease of percent area stenosis (12.7±10.5% versus 37.9±12.4%) and maximal neointimal area (0.42±0.39 versus 1.59±0.78 mm²) in comparison with control animals (n=9). Dr Wiederman concluded that intracoronary irradiation significantly reduces restenosis after balloon . . . [Full Text of this Article]