(Circulation. 1999;99:578-588.)
© 1999 American Heart Association, Inc.
Current Perspective |
Glucose for the Heart
From the Department of Internal Medicine (C.D., H.T.), Division of Cardiology, University of Texas Houston Medical School; and Institute of Cellular and Molecular Pathology (C.D.) and Division of Cardiology (J.-L.J.V.), University of Louvain Medical School, Brussels, Belgium.
Key Words: metabolism • glucose • heart failure • ischemia • myocardium
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Introduction |
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The homeostasis of plasma glucose levels is essential for survival of the mammalian organism. Since blood glucose concentration is maintained within a narrow range, glucose is a most reliable substrate for energy production in the heart. The importance of glucose metabolism via glycolysis is well appreciated in ischemic and hypertrophied heart muscle,1 2 3 4 but aerobic glucose metabolism for support of normal contractile function has received less attention, mainly because of the well-known fact that fatty acids are normally the predominant fuel for cardiac energy production.2 5 6 We have drawn attention to the heart as a true "omnivore," ie, an organ that functions best when it oxidizes different substrates simultaneously.7 In light of this concept, we wish to reexamine myocardial glucose metabolism and its relevance to the human heart. In recent years, the tools of molecular and cellular biology have provided new insight into the mechanisms of glucose transport and phosphorylation. Glycogen metabolism has come into greater focus. The regulation of glycolysis is more accurately defined, and the effects of second messengers on myocardial glucose utilization are better known. In view of this background, 2 well-known clinical concepts of myocardial glucose metabolism require critical reevaluation: (1) the diagnostic concept of metabolic imaging with PET and the glucose tracer analogue 18F-2-deoxy-2-fluoro-D-glucose (FDG) and (2) the therapeutic concept of metabolic support for the postischemic heart with glucose, insulin, and K+ (GIK).
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Regulation of Glucose Metabolism in Normoxic Heart |
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The simple sugar D-glucose is the most abundant organic molecule in nature. Glucose for the heart is derived either from the
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|
|
|
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|
|
|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 G. C. Hughes, M. J. Post, M. Simons, and B. H. Annex Translational Physiology: Porcine models of human coronary artery disease: implications for preclinical trials of therapeutic angiogenesis J Appl Physiol, May 1, 2003; 94(5): 1689 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Taegtmeyer Improving Energy Metabolism in the Postischemic Heart-The Story of GIK Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2003; 7(1): 67 - 76. [Abstract] [PDF]
|
|
|
|
|
|
H. B. van Wezel and S. W. M. d. Jong Clinical Use of Glucose-Insulin-Potassium in Cardiac Surgery andAcute Myocardial Infarction: An Overview Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2003; 7(1): 77 - 83. [PDF]
|
|
|
|
|
|
I. Friehs and P. J. del Nido Increased susceptibility of hypertrophied hearts to ischemic injury Ann. Thorac. Surg., February 1, 2003; 75(2): S678 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V K Khoury, B Haluska, J Prins, and T H Marwick Effects of glucose-insulin-potassium infusion on chronic ischaemic left ventricular dysfunction Heart, January 1, 2003; 89(1): 61 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Eynan, T. Knubuvetz, U. Meiri, G. Navon, G. Gerstenblith, Z. Bromberg, Y. Hasin, and M. Horowitz Heat acclimation-induced elevated glycogen, glycolysis, and low thyroxine improve heart ischemic tolerance J Appl Physiol, December 1, 2002; 93(6): 2095 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Herrero, T. L. Sharp, C. Dence, B. M. Haraden, and R. J. Gropler Comparison of 1-11C-Glucose and 18F-FDG for Quantifying Myocardial Glucose Use with PET J. Nucl. Med., November 1, 2002; 43(11): 1530 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Bacharach and S. K. Sundaram 18F-FDG in Cardiology and Oncology: The Bitter with the Sweet J. Nucl. Med., November 1, 2002; 43(11): 1542 - 1544. [Full Text] [PDF]
|
|
|
|
|
|
S. D. Solomon, M. S. J. Sutton, G. A. Lamas, T. Plappert, J. L. Rouleau, H. Skali, L. Moye, E. Braunwald, M. A. Pfeffer, and for the Survival And Ventricular Enlargement (SAVE Ventricular Remodeling Does Not Accompany the Development of Heart Failure in Diabetic Patients After Myocardial Infarction Circulation, September 3, 2002; 106(10): 1251 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Vogt, M. Poolman, C. Ackermann, M. Yildiz, W. Schoels, D. A. Fell, and W. Kubler Regulation of Glycolytic Flux in Ischemic Preconditioning. A STUDY EMPLOYING METABOLIC CONTROL ANALYSIS J. Biol. Chem., June 28, 2002; 277(27): 24411 - 24419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Taegtmeyer, P. McNulty, and M. E. Young Adaptation and Maladaptation of the Heart in Diabetes: Part I: General Concepts Circulation, April 9, 2002; 105(14): 1727 - 1733. [Full Text] [PDF]
|
|
|
|
|
|
Y. Cottin, I. Lhuillier, L. Gilson, M. Zeller, C. Bonnet, C. Toulouse, P. Louis, L. Rochette, C. Girard, and J.-E. Wolf Glucose insulin potassium infusion improves systolic function in patients with chronic ischemic cardiomyopathy Eur J Heart Fail, March 1, 2002; 4(2): 181 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P Lydell, A. Chan, R. B Wambolt, N. Sambandam, H. Parsons, G. P Bondy, B. Rodrigues, K. M Popov, R. A Harris, R. W Brownsey, et al. Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat hearts Cardiovasc Res, March 1, 2002; 53(4): 841 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A Nikolaidis, T. Hentosz, A. Doverspike, R. Huerbin, C. Stolarski, Y.-T. Shen, and R. P Shannon Catecholamine stimulation is associated with impaired myocardial O2 utilization in heart failure Cardiovasc Res, February 1, 2002; 53(2): 392 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
J. J. Krueger, X.-H. Ning, B. M. Argo, O. Hyyti, and M. A. Portman Triidothyronine and epinephrine rapidly modify myocardial substrate selection: a 13C isotopomer analysis Am J Physiol Endocrinol Metab, November 1, 2001; 281(5): E983 - E990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Korvald, O. P. Elvenes, T. Myrmel, and D. G. Sorlie Cardiac dysfunction and inefficiency after substrate-enriched warm blood cardioplegia Eur. J. Cardiothorac. Surg., September 1, 2001; 20(3): 555 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Terrand, I. Papageorgiou, N. Rosenblatt-Velin, and R. Lerch Calcium-mediated activation of pyruvate dehydrogenase in severely injured postischemic myocardium Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H722 - H730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tian and E. D. Abel Responses of GLUT4-Deficient Hearts to Ischemia Underscore the Importance of Glycolysis Circulation, June 19, 2001; 103(24): 2961 - 2966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jagasia, J. M. Whiting, J. Concato, S. Pfau, and P. H. McNulty Effect of Non-Insulin-Dependent Diabetes Mellitus on Myocardial Insulin Responsiveness in Patients With Ischemic Heart Disease Circulation, April 3, 2001; 103(13): 1734 - 1739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
C. Ceconi, P. Bernocchi, A. Boraso, A. Cargnoni, P. Pepi, S. Curello, and R. Ferrari New insights on myocardial pyridine nucleotides and thiol redox state in ischemia and reperfusion damage Cardiovasc Res, August 18, 2000; 47(3): 586 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Pagano, J N Townend, D V Parums, R S Bonser, and P G Camici Hibernating myocardium: morphological correlates of inotropic stimulation and glucose uptake Heart, April 1, 2000; 83(4): 456 - 461. [Abstract] [Full Text]
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|
|
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C. Korvald, O. P. Elvenes, and T. Myrmel Myocardial substrate metabolism influences left ventricular energetics in vivo Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1345 - H1351. [Abstract] [Full Text] [PDF]
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P. Zhu, L. Lu, Y. Xu, C. Greyson, and G. G. Schwartz Glucose-insulin-potassium preserves systolic and diastolic function in ischemia and reperfusion in pigs Am J Physiol Heart Circ Physiol, February 1, 2000; 278(2): H595 - H603. [Abstract] [Full Text] [PDF]
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