KRP-203, a Novel Synthetic Immunosuppressant, Prolongs Graft Survival and Attenuates Chronic Rejection in Rat Skin and Heart Allografts
Circulation Shimizu et al.
111: 222
Data Supplement
Figure. Effect of KRP-203 combined with CsA on rat heart allografts. (A) HE and MT staining showed that severe acute rejection, characterized by diffuse mononuclear cell infiltration, hemorrhage, and myocardial necrosis, was prevented with KRP-203 (1 mg/kg) combined with CsA (3 mg/kg). No acute rejection was observed in the isografts. (B) Immunohistochemical staining showed that infiltration of macrophages and T cells in the allografts was prevented in KRP-203 (1 mg/kg) combined with CsA (3 mg/kg).
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