This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kleber, F. X. Articles by Gläser, S. Search for Related Content PubMed PubMed Citation Articles by Kleber, F. X. Articles by Gläser, S. Related Collections Congestive Exercise testing

(Circulation. 2000;101:2803.)
© 2000 American Heart Association, Inc.

Clinical Investigation and Reports

Impairment of Ventilatory Efficiency in Heart Failure

Prognostic Impact

F. X. Kleber, MD; G. Vietzke, MD; K. D. Wernecke, PhD; U. Bauer, MD; C. Opitz, MD; R. Wensel, MD; A. Sperfeld, MD; S. Gläser, MD

From Medizinische Klinik und Poliklinik I, Universitätsklinikum Charité, Arbeitsgruppe Medizinische Biometrie, Humboldt-Universität zu Berlin, Berlin, Germany.

	Abstract

Top Abstract Introduction Methods Results Discussion References

 
Background—Impairment of ventilatory efficiency in congestive heart failure (CHF) correlates well with symptomatology and contributes importantly to dyspnea.

Methods and Results—We investigated 142 CHF patients (mean NYHA class, 2.6; mean maximum oxygen consumption [O₂max], 15.3 mL O₂ · kg^-1 · min^-1; mean left ventricular ejection fraction [LVEF], 27%). Patients were compared with 101 healthy control subjects. Cardiopulmonary exercise testing was performed, and ventilatory efficiency was defined as the slope of the linear relationship of CO₂ and ventilation (VE). Results are presented in percent of age- and sex-adjusted mean values. Forty-four events (37 deaths and 7 instances of heart transplantation, cardiomyoplasty, or left ventricular assist device implantation) occurred. Among O₂max, NYHA class, LVEF, total lung capacity, and age, the most powerful predictor of event-free survival was the VE versus CO₂ slope; patients with a slope 130% of age- and sex-adjusted normal values had a significantly better 1-year event-free survival (88.3%) than patients with a slope >130% (54.7%; P<0.001).

Conclusions—The VE versus CO₂ slope is an excellent prognostic parameter. It is easier to obtain than parameters of maximal exercise capacity and is of higher prognostic importance than O₂max.

Key Words: prognosis • heart failure • ventilation

	Introduction

Top Abstract Introduction Methods Results Discussion References

 
Ventilatory efficiency is defined by ventilation relative to CO₂ production. Its most important determinant is the matching of ventilation and perfusion. In most patients with congestive heart failure (CHF), as in normal control subjects, ventilatory efficiency improves with exercise. It correlates very well with exercise capacity respectively O₂max¹ and closely relates to symptomatology.^{2 3} Both NYHA class and O₂max have been proven to be good predictors of prognosis in CHF. Therapy with ACE inhibitors known to improve prognosis also betters ventilatory efficiency.³ Ventilatory efficiency can be derived from a moderate effort well before exhaustion and is highly reproducible.¹

Therefore, we investigated the impact of ventilatory efficiency in CHF on outcome and compared it with other prognostic parameters like left ventricular ejection fraction (LVEF), NYHA class, and O₂max. To maximize the physiological information from cardiopulmonary exercise testing (CPX), we normalized O₂max and the slope of ventilation (VE) versus CO₂ for age and sex using our own control population.^{4 5}

	Methods

Top Abstract Introduction Methods Results Discussion References

 
Patients
We monitored 142 consecutive patients (117 men, 25 women; mean age, 51.6±10 years; range, 21 to 73 years) with CHF after performing CPX between June 1993 and November 1996. Mean and median follow-up until death or end of follow-up was 16 months. The cause of CHF was coronary artery disease (n=70), dilated cardiomyopathy (n=66), valvular heart disease (n=4), graft failure (n=1), and hypertensive heart disease (n=1). Eleven patients were in NYHA class IV, 78 in class III, and 45 in class II; 8 patients did not complain of symptomatic limitation (class I).

Symptoms were attributed to heart and not lung disease in all patients, albeit the mild abnormality of pulmonary function tests in some patients was thought to be secondary to heart disease. Current smoking status and smoking history are presented in Table 1.

View this table: [in this window] [in a new window]   Table 1. Lung Function Tests and Smoking Status

Origin and severity of CHF were determined by echocardiography (n=130), chest radiograph (n=114), or cardiac catheterization (n=95). Inclusion criteria were a O₂max <25 mL O₂ · kg^-1 · min^-1 and either cardiothoracic ratio >0.5, echocardiographic left ventricular end-diastolic diameter 57 mm, or LVEF determined by contrast ventriculography or echocardiography 45%. Mean LVEF was 27% (median, 26%). One hundred nineteen patients were in sinus rhythm, 19 had atrial fibrillation, and 4 had pacemaker rhythm.

Current medication included ACE inhibitors (89%), diuretics (69%), nitrates (67%), digitalis (52%), anticoagulants (30%), and antiarrhythmics (6%). Ten percent were on calcium antagonists, mainly for rate control, and 31% were on aspirin for coronary disease.

Control Subjects
One hundred one healthy volunteers 16 to 75 years of age (mean, 37±14 years) underwent CPX testing to establish age- and sex-corrected normal values. Forty-five were female (weight, 60±8 kg; height, 165±6 cm), 56 were male (weight, 78±12 kg; height, 179±9 cm). Results have been published in part elsewhere.⁴ Linear regression analysis for age versus oxygen consumption and VE versus CO₂ slope revealed the following mean normal value formulas: VE versus CO₂ slope: 0.13xage+19.9 for men and 0.12xage+24.4 for women; O₂ at the gas exchange anaerobic threshold (O₂AT): -0.17xage+28.6 for men and -0.16xage+24.2 for women; O₂max: -0.36xage+51.5 for men and -0.34xage+44.6 for women.

For prognostic analysis, oxygen consumption and VE versus CO₂ slope values are presented as percent predicted (PP) from the individual age- and sex-corrected mean normal values.

Exercise Testing
In all patients and control subjects, a symptom-limited CPX test was performed according to the modified Naughton protocol⁶ with a Medical Graphics CPX/D system. Details of our test protocol have been published earlier.⁴

Great effort was undertaken not to stop exercise prematurely. However, indications to stop the test were a higher degree of AV block or ventricular tachycardia >5 consecutive beats at a rate >120/min, new atrial fibrillation, ST-segment depression >3 mm, or systolic blood pressure >260 mm Hg, as well as a progressive decrease in blood pressure.

O₂max was defined as the peak O₂ measured, always occurring well beyond the anaerobic threshold. O₂ at O₂AT was detected by the V-slope method,^{7 8} supplemented by simultaneous observation of end-tidal gas concentrations (PETO₂/CO₂).

Ventilatory efficiency on exercise was measured by plotting VE against CO₂. This plot revealed a linear relationship (r=0.98 to 0.99). The ventilatory efficiency on exercise is represented by its slope. The nonlinear part of this relationship after onset of acidotic drive to ventilation⁸ was excluded.

Lung Function Tests
Routine lung function tests, including total lung capacity (TLC), forced expiratory volume in 1 second (FEV₁), inspiratory vital capacity (IVC), and diffusion capacity for carbon monoxide (DLCO), were expressed as percent predicted of normal PP. Oxygen saturation was continuously measured percutaneously by pulse oximetry on the ear lobe. Breathing reserve was calculated as 100-(100xVE_max/resting FEV₁x41).⁹

Follow-Up Data on Prognosis
Follow-up events included overall deaths, cardiac transplantation (HTX), implantation of a left ventricular assist device (LVAD), or cardiomyoplasty. Most patients had a follow-up of >1 year. Minimal follow-up was 6 months. One patient was lost to follow-up.

Statistical Analysis
Results are presented as mean±SD. For comparison between groups, the Mann-Whitney U test was used; to compare prognostic parameters, linear and logistic regression analyses were performed. Correlations were determined according to Bravais-Pearson or Spearman. The follow-up data were analyzed by Kaplan-Meier life-table analysis and the log-rank test. To define the cutoffs giving the best discrimination in defining the likelihood of event-free survival, univariate log-rank tests (Mantel-Haenszel)¹⁰ were used. A multiple Cox regression analysis was performed using LVEF, O₂max, VE versus CO₂ slope, age, TLC, and NYHA class.¹¹

Classification trees (CART) were constructed with subgroups internally as homogeneous and externally as heterogeneous as possible, measured on the corresponding log-rank test.^{12 13} The successive splits of the tree correspond to the features with the greatest prognostic importance. For diagnostic testing sensitivity, accuracy and ORs were estimated.

	Results

Top Abstract Introduction Methods Results Discussion References

 
Exercise Testing
Eighty-nine patients terminated exercise because of dyspnea, 15 because of angina, 13 because of fatigue, 10 because of nonspecific symptoms like vertigo and anxiety, and 15 because of the above-defined criteria. All exercise tests in control subjects were limited by exhaustion.

O₂AT and O₂max were 10.7±3.2 and 15.2±4.7 mL O₂ · kg^-1 · min^-1 (median, 57 and 47 PP), respectively, in the patient group. The VE versus CO₂ slope was 39.3±16.4 (median, 128 PP). There was no difference between the 2 major etiologic subgroups.

At termination of exercise, patients used 44±15% of maximal breathing capacity; healthy volunteers, 59±12%. In patients and in all NYHA subgroups, O₂max was reached earlier after O₂AT than in normal subjects (O₂AT/O₂max in patients, 71±11%; in normal subjects, 58±9%; P<0.001; see Table 2). Termination of exercise because of angina or by the physician did not influence the O₂AT/O₂max ratio. Patients with normal and reduced ventilatory efficiency had similar O₂AT/O₂max ratios (71±11% versus 72±10%).

View this table: [in this window] [in a new window]   Table 2. VO2 and VE versus CO2 Slope in Subsets With Different Severity of CHF

Oxygen Desaturation and Lung Function Testing
In 6 of 142 patients, a significant decrease in oxygen saturation (4%) was found (mean, 96% to 87%). Five of these were in NYHA class III, and 1 was in class IV. One had a small atrial septum defect, and 1 had suspected pulmonary embolism with extremely elevated VE versus CO₂ slope (140) normalized at reevaluation. The other 4 had severe CHF (O₂AT, 4.7 to 9.0; O₂max, 6.1 to 11.2 mL O₂ · kg^-1 · min^-1; VE versus CO₂ slope, 57 to 85), and all 4 died within 2 years. Lung function and smoking status are given in Table 1.

Relationship Between Ventilatory Efficiency, Symptoms, and Exercise Capacity
Ventilatory efficiency was impaired (VE versus CO₂ slope >35) in 46% of patients. Patients with reduced ventilatory efficiency had lower LVEF (20±7% versus 25±8%; P<0.001) and O₂max (12.2±3.6 versus 17.8±3.9; P<0.001) than patients without reduced ventilatory efficiency.

Results in various NYHA classes are presented in Table 2. The VE versus CO₂ slope but not O₂AT or O₂max was significantly different in all NYHA classes (P<0.05), but the correlation between VE versus CO₂ slope and NYHA class was not very good (r=0.44; P<0.001). Exercise ventilatory efficiency correlated with O₂AT (r=-0.70, P<0.001), O₂max (r=-0.70; P<0.001), and exercise time (r=-0.53; P<0.001) but only weakly with LVEF (r=-0.17; P=0.048).

The correlations between exercise capacity and ventilatory efficiency were similar using the PP values (VO₂max PP and slope PP: r=-0.64; P<0.001; O₂AT PP and slope PP: r=0.65; P<0.001).

Follow-Up of Vital Status
Thirty-seven deaths occurred during follow-up. An additional 7 patients survived HTX, cardiomyoplasty, or LVAD implantation. Eight deaths occurred at various time intervals after prior HTX, LVAD, or cardiomyoplasty. Median event-free survival was 38 months (overall survival, 39 months). Univariate Kaplan-Meier analysis of event-free survival revealed significant survival differences (log-rank test) with cutoff points for O₂AT at 10 mL · kg^-1 · min^-1 or 30, 45, and 50 PP; O₂max at 10, 12, and 14 mL · kg^-1 · min^-1 or 45 PP; and VE versus CO₂ slope at 35 and 40 L/L CO₂ or 125 and 130 PP.

Figure 1 shows the event-free survival for the total group, and Figure 2a and 2b shows Kaplan-Meier life-table analyses (event-free survival) for the best cutoffs, ie, O₂max (>45 versus 45 PP) and VE versus CO₂ slope (130 versus >130 PP). The best cutoff for O₂AT was >50 versus 50 PP (life table not shown).

View larger version (10K): [in this window] [in a new window]   Figure 1. Event-free survival for total patient group.

View larger version (16K): [in this window] [in a new window]   Figure 2. Kaplan-Meier life-table analysis for O2max >45% vs 45% predicted (a) and for VE vs CO2 slope 130% vs >130% predicted (b).

In a multivariate Cox regression analysis, the following items were included: age, LVEF, NYHA class, O₂max, VE versus CO₂ slope, and TLC. The analysis revealed the VE versus CO₂ slope to be the most powerful predictor of event-free survival, followed by O₂max. O₂max did not substantially improve the predictive value of the model. Classification trees were used to estimate the practical usefulness of the model to predict 1-year overall and event-free survival. Of the 141 patients, 105 were survivors of the first year of follow-up, and 103 survived without an event. According to the best discriminating variable and cutoffs in the log-rank statistics, we included the following parameters/cutoffs in the CART analysis: O₂AT cutoff, 50 PP; VE versus CO₂ slope, 130 PP; NYHA functional class, I/II versus III/IV and I to III versus IV; O₂max cutoff, 45 PP; age, 65 years; and LVEF, 25%. The VE versus CO₂ slope had by far the highest log-rank test value (25.65; P<0.0001), followed by O₂max (with a log-rank test value of 7.57; P=0.0059). The VE versus CO₂ slope was therefore used as the first parameter to dichotomize the patients. Analysis for event-free and overall survival revealed essentially the same: both the VE versus CO₂ slope in PP and the O₂max PP represented important information for the prognosis. Patients with a VE versus CO₂ slope 130 PP had a significantly better 1-year event-free survival (88.3%) than patients with a slope >130 PP who had a 1-year event-free survival of only 54.7% (overall survival, 88.3% versus 57.8%).

Patients with a VE versus CO₂ slope >130 PP but a O₂max >45 PP had a 79.2% 1-year event-free survival. No other parameters were useful to further characterize the prognosis of patients with a VE versus CO₂ slope 130 PP who had a good prognosis. For details, see Figure 3.

View larger version (38K): [in this window] [in a new window]   Figure 3. CART analysis with successive splits according to greatest prognostic importance of variables with respect to 1-year event-free survival (a) and CART analyses with successive splits according to various clinical decisions with respect to 1-year survival (b through e).

The sensitivity and specificity of a VE versus CO₂ slope with a cutoff of 130 PP for survival were 70.3% and 63.5%; positive and negative predictive values were 40.6% and 85.7%, accuracy was 65.3%, the OR was 4.1, and the 95% CI was 1.9 to 9.0.

	Discussion

Top Abstract Introduction Methods Results Discussion References

 
Dyspnea and Ventilatory Efficiency
The most widely used scale to measure dyspnea in CHF is the NYHA classification, which, in contrast to the Borg scale and pulmonary function tests, has been shown to contribute prognostic information independently of left ventricular function.^{14 15}

One of the most prominent features of dyspnea in CHF is hyperpnea, ie, an increase in ventilation relative to gas exchange. It is caused by early anaerobic metabolism, an increase in anatomical dead space by increased breathing rate and low tidal volumes caused by secondary restrictive physiology or respiratory muscle fatigue,¹⁶ a decreased PaCO₂ set point resulting from acidosis, disturbances of diffusion,¹⁷ activation of muscle ergoreceptors,¹⁸ and respiratory muscle deoxygenation.¹⁹ The most important cause of hyperpnea, however, is the increase in physiological dead space by alveolar hypoperfusion^{20 21} Therefore, we investigated the prognostic importance of ventilatory efficiency in patients with CHF and compared it with other currently used prognostic parameters like LVEF,^{22 23} NYHA class,^{24 25} and O₂max.

Population Under Study
Patients suffered mainly from coronary disease or dilated cardiomyopathy similar to recently reported patients.²⁶ All patients had an LVEF 45%; all NYHA I patients had an LVEF <35%.

There was no difference in smoking status in patients with reduced compared with normal ventilatory efficiency. Differences in pulmonary function tests were small and thought to be secondary to CHF. Lungs were somewhat smaller in patients with reduced ventilatory efficiency, as has been shown in normal subjects under exercise²⁷ and in persons susceptible to high-altitude pulmonary edema.²⁸ This might contribute to / mismatch by making a small ventilation-perfusion inequality more important. The slight decrease in TLC in our patients, however, is unlikely to contribute to a larger extent to the decrease in ventilatory efficiency. Forty-six percent of patients had reduced ventilatory efficiency (median, 128 PP).

Similar to Veterans Administration Heart Failure Trial (V-HeFT) findings,²⁹ mean O₂max was 15.2 mL · kg^-1 · min^-1, and cardiocirculatory limitation was confirmed by the high breathing reserve at the end of exercise, low rate of oxygen desaturation, and absence of pulmonary disease.

The lack of any important correlation to LVEF is not unexpected,^{23 30} and an LVEF 30% might not give very useful information regarding prognosis.^{14 31} More than 70% of our population had an LVEF 30%.

Follow-Up of Vital Status and CHF Events
Prognostic parameters in CHF²⁴ include symptoms,^{25 32 33} hemodynamics, LVEF, cardiothoracic ratio,²⁹ neurohormones,^{34 35} electrolytes,³⁶ and O₂max.^{31 37 38} We used O₂ PP derived from our own large control population. Among LVEF, NYHA class, age, and TLC, the VE versus CO₂ slope was the most powerful indicator of prognosis in a multivariate analysis.

VE/CO₂ ratio and slope are known to correlate to O₂max.³⁹ Our results demonstrate that the VE versus CO₂ slope contains prognostic information in addition to and beyond the measurement of O₂max: Patients with a VE versus CO₂ slope >130 PP had a 1-year mortality >40%, and even if O₂max were preserved, 1-year mortality was >20%. Ventilatory efficiency is easier to obtain than O₂max and can be derived from a submaximal exercise test. The high negative predictive value of a normal ventilatory efficiency (ie, slope 130 PP) is of special clinical relevance for patients with low O₂max or those who cannot exercise until exhaustion.

Underlying Physiology and Study Limitations
This study lacks an explanation of how ventilatory efficiency affects prognosis in CHF. Although normal ventilatory control in CHF⁴⁰ has been shown, an uncoupling of ventilation from CO₂ production⁴¹ has also been reported and thought to be due to activation of muscle ergoreceptors. However, substantial changes in arterial CO₂ tension have not been found,^{40 42 43} and the changes in physiological dead space suggested by increased ventilation^{40 42 43} and near-normal PCO₂ would thus be secondary.

An alternative explanation is that the increase in physiological dead space is directly caused by alveolar hypoperfusion⁴⁴ resulting from impaired endothelial vasodilatory capacity^{45 46 47} or neuroendocrine activation.^{35 48} If this theory is correct, the "muscle hypothesis" would not easily fit in.

A major diffusion disturbance^{17 49} is an unlikely explanation for the derangement of ventilatory efficiency because CO₂ diffuses much more easily than oxygen and a decrease in oxygen saturation has not been found in >95% of our patients. It might become important in severe CHF with prominent congestion.

Another limitation of our study is that not all patients stopped exercise for dyspnea or fatigue. This might introduce a considerable error through ischemic pump dysfunction. However, the reluctance to include patients with angina would not have reliably excluded silent ischemia, nor would it be meaningful to disregard some contribution of ischemia in a setting of CHF, whose leading cause is ischemic heart disease. Furthermore, dyspnea might be the only symptom of angina. Thus, in any exercise testing of CHF patients, ischemia is likely to play some part. The VE versus CO₂ relationship should, on the contrary, be of special value in this population, because it is measured well before the onset of angina or ischemia. Furthermore, the exclusion of patients who stopped exercise before the onset of dyspnea or fatigue led to a similar ratio of O₂max/O₂AT. This indicates that our patients did not stop because of angina; rather, ischemia concurred with the limitation by CHF at the end of exercise in some of them.

Despite these limitations, our results show that measurement of the VE versus VCO₂ relationship offers a unique way of estimating the prognosis of patients with CHF. During preparation of this article, similar results have been obtained by an independent group.⁵⁰ Given the possibility of therapeutic influences on ventilatory efficiency,³ this might also provide a useful tool to guide therapy, especially in severe CHF.

	Acknowledgments

 
This work was supported by grant No. 01 ZZ 9101 from the Ministry of Research, Germany.

	Footnotes

 
Reprint requests to F.X. Kleber, MD, Professor of Medicine, Humboldt University, Berlin, Director Department of Internal Medicine, Unfallkrankenhaus Berlin, Warener Straße 7, 12683 Berlin, Germany.

Received September 14, 1999; revision received January 15, 2000; accepted January 25, 2000.

	References

Top Abstract Introduction Methods Results Discussion References

 
1. Metra M, Dei Cas L, Panina G, et al. Exercise hyperventilation in chronic congestive heart failure, and its relation to functional capacity and hemodynamics. Am J Cardiol. 1992;70:622–628.[Medline] [Order article via Infotrieve]

2. Kleber FX, Reindl I, Wernecke KD, et al. Dyspnea in heart failure. In: Wasserman K, ed. Exercise Gas Exchange in Heart Disease. Armonk, NY: Futura Publishing Co Inc; 1996:95–107.

3. Reindl I, Kleber FX. Exertional hyperpnea in patients with chronic heart failure is a reversible cause of exercise intolerance. Basic Res Cardiol. 1996;91(suppl 1):37–43.

4. Habedank D, Reindl I, Vietzke G, et al. Ventilatory efficiency and exercise tolerance in 101 healthy volunteers. Eur J Appl Physiol. 1998;77:421–426.

5. Habedank D, Reindl I, Sonntag CF, et al. Ventilatory efficacy in healthy volunteers during cardiopulmonary exercise testing. Eur J Appl Physiol. 1994;69(suppl 3):14. Abstract.

6. Weber KT, Kinasewitz GT, Janicki JS, et al. Oxygen utilization and ventilation during exercise in patients with chronic cardiac failure. Circulation. 1982;65:1213–1223.[Abstract/Free Full Text]

7. Beaver WL, Lamarra N, Wasserman K. Breath-by-breath measurement of true alveolar gas exchange. J Appl Physiol. 1981;51:1662–1675.[Abstract/Free Full Text]

8. Wasserman K, Stringer WW, Casaburi R, et al. Determination of the anaerobic threshold by gas exchange: biochemical considerations, methodology and physiological effects. Z Kardiol. 1994;83(suppl III):1–12.

9. Miller WF, Scacci R, Gast LR. Laboratory Evaluation of Pulmonary Function. Philadelphia, Pa: JB Lippincott Co; 1987;300.

10. Wernecke K-D. Angewandte Statistik für die Praxis. Bonn, Germany: Addison Wesley Publishing Co; 1995.

11. Kalbfleisch J, Prentics RL. The Statistical Analysis of Failure Time Data. New York, NY: John Wiley & Sons; 1980.

12. Wernecke K-D, Possinger K, Kalb G, et al. Validating classification trees. Biometrical J. 1998;40:993–1005.

13. Hartung J. Statistik Lehr und Handbuch der angewandten Statistik. München, Germany: Oldenburg Verlag; 1993.

14. Rickenbacher PR, Trindade PT, Haywood GA, et al. Transplant candidates with severe left ventricular dysfunction managed with medical treatment: characteristics and survival. J Am Coll Cardiol. 1996;27:1192–1197.[Abstract]

15. Borg GAV. Psychophysical basis of perceived exertion. Med Sci Sports Exerc. 1982;14:377–381.[Medline] [Order article via Infotrieve]

16. Witt C, Borges AC, Haake H, et al. Respiratory muscle weakness and normal ventilatory drive in dilative cardiomyopathy. Eur Heart J. 1997;18:1322–1328.[Abstract/Free Full Text]

17. Puri S, Baker BL, Oakley CM, et al. Increased alveolar/capillary membrane resistance to gas transfer in patients with chronic heart failure. Br Heart J. 1994;72:140–144.[Abstract/Free Full Text]

18. Clark AL, Piepoli M, Coats AJS. Evidence for skeletal and muscle metabolic receptors driving ventilation on exercise. Circulation. 1993;88(suppl I):I-415. Abstract.

19. Mancini DM, Ferraro N, Nazzaro D, et al. Respiratory muscle deoxygenation during exercise in patients with heart failure demonstrated with near-infrared spectroscopy. J Am Coll Cardiol. 1991;18:492–498.[Abstract]

20. Reindl I, Wernecke KD, Opitz C, et al. Impaired ventilatory efficiency in chronic heart failure: possible role of pulmonary vasoconstriction. Am Heart J. 1998;136:778–785.[Medline] [Order article via Infotrieve]

21. Buller NP, Poole-Wilson PA. Mechanisms of the increased ventilatory response to exercise in patients with chronic heart failure. Br Heart J. 1990;63:281–283.[Abstract/Free Full Text]

22. Higginbotham MB, Morris KG, Conn EH, et al. Determinants of variable exercise performance among patients with severe left ventricular dysfunction. Am J Cardiol. 1983;51:52–60.[Medline] [Order article via Infotrieve]

23. Franciosa JA, Park M, Levine TB. Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failure. Am J Cardiol. 1981;47:33–39.[Medline] [Order article via Infotrieve]

24. Stevenson LW. Heart transplant centers: no longer the end of the road for heart failure. J Am Coll Cardiol. 1996;27:1198–1200.[Medline] [Order article via Infotrieve]

25. Di Salvo TG, Mathier M, Semigran MJ, et al. Preserved right ventricular ejection fraction predicts exercise capacity and survival in advanced heart failure. J Am Coll Cardiol. 1995;25:1143–1153.[Abstract]

26. Cohn JN, Johnson G, Ziesche S, et al. A Comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure (V-HeFT II). N Engl J Med. 1991;325:303–310.[Abstract]

27. Hopkins SR, Gavin T, Siavakas N, et al. Effect of prolonged, heavy exercise on pulmonary gas exchange in athletes. J Appl Physiol. 1998;85:1523–1532.[Abstract/Free Full Text]

28. Podolsky A, Eldridge MW, Richardson RS, et al. Exercise-induced VA/Q inequality in subjects with prior high-altitude pulmonary edema. J Appl Physiol. 1996;81:922–932.[Abstract/Free Full Text]

29. Cohn JN, Johnson GR, Shabetai R, et al, for the V-HeFT VA Cooperative Studies Group. Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. Circulation. 1993;87(suppl VI):VI-5. Abstract.

30. Cohn JN. The management of chronic heart failure. N Engl J Med. 1996;335:490–498.[Free Full Text]

31. Stelken AM, Younis LT, Jennison SH, et al. Prognostic value of cardiopulmonary exercise testing using percent achieved of predicted peak oxygen uptake for patients with ischemic and dilated cardiomyopathy. J Am Coll Cardiol. 1996;27:345–352.[Abstract]

32. Saxon LA, Stevenson WG, Middlekauf HR, et al. Predicting death from progressive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 1993;72:62–65.[Medline] [Order article via Infotrieve]

33. Campana C, Gavazzi A, Berzuini C, et al. Predictors of prognosis in patients awaiting heart transplantation. J Heart Lung Transplant. 1993;12:756–765.[Medline] [Order article via Infotrieve]

34. Rector TS, Olivari MT, Levine TB, et al. Predicting survival for an individual with congestive heart failure using the plasma norepinephrine concentration. Am Heart J. 1987;114:148–152.[Medline] [Order article via Infotrieve]

35. Francis GS, Rector TS, Cohn JN. Sequential neurohormonal measurements in patients with congestive heart failure. Am Heart J. 1988;116:1464–1468.[Medline] [Order article via Infotrieve]

36. Lee WH, Packer M. Prognostic importance of serum sodium concentration and its modification by converting-enzyme inhibition in patients with severe chronic heart failure. Circulation. 1986;73:257–267.[Abstract/Free Full Text]

37. Mancini DM, Eisen H, Kussmaul W, et al. Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation. 1991;83:778–786.[Abstract/Free Full Text]

38. Stevenson LW. Role of exercise testing in the evaluation of candidates for cardiac transplantation. In: Wasserman K, ed. Exercise Gas Exchange in Heart Disease. Armonk, NY: Futura Publishing Co Inc; 1995:271–286.

39. Milani RV, Mehra MR, Reddy TK, et al. Ventilation/carbon dioxide production ratio in early exercise predicts poor functional capacity in congestive heart failure. Heart. 1996;76:393–396.[Abstract/Free Full Text]

40. Sullivan MJ, Higginbotham MB, Cobb FR. Increased exercise ventilation in patients with chronic heart failure: intact ventilatory control despite hemodynamic and ventilatory abnormalities. Circulation. 1988;77:552–559.[Abstract/Free Full Text]

41. Clark AL, Poole-Wilson PA, Coats AJ. Relation between ventilation and carbon dioxide production in patients with chronic heart failure. J Am Coll Cardiol. 1992;20:1326–1332.[Abstract]

42. Franciosa JA, Leddy CL, Wilen M, et al. Relation between hemodynamic and ventilatory responses in determining exercise capacity in severe congestive heart failure. Am J Cardiol. 1984;53:127–134.[Medline] [Order article via Infotrieve]

43. Raijfer SI, Nemanich JW, Schurman AJ, et al. Metabolic responses to exercise in patients with heart failure. Circulation. 1987;76(suppl VI):VI-46–VI-53.

44. Myers J, Salleh A, Buchanan N, et al. Ventilatory mechanisms of exercise intolerance in chronic heart failure. Am Heart J. 1992;124:710–718.[Medline] [Order article via Infotrieve]

45. Cooper CJ, Landzberg MJ, Anderson TJ, et al. Role of nitric oxide in the local regulation of pulmonary vascular resistance in humans. Circulation. 1996;93:266–271.[Abstract/Free Full Text]

46. Celermajer DS, Dollery C, Burch M, et al. Role of endothelium in the maintenance of low pulmonary vascular tone in normal children. Circulation. 1994;89:2041–2044.[Abstract/Free Full Text]

47. Kleber FX, Wensel R, Felix SB, et al. Acetylcholine causes dose dependent increase in pulmonary flow in patients with chronic heart failure and elevated pulmonary vascular resistance. Basic Res Cardiol. 1996;91:401–405.[Medline] [Order article via Infotrieve]

48. Nicholls P, Onuoha GN, McDowell G, et al. Neuroendocrine changes in chronic heart failure. Basic Res Cardiol. 1996;91(suppl I):13–20.

49. Puri S, Baker BL, Dutka DP, et al. Reduced alveolar-capillary membrane diffusing capacity in chronic heart failure: its pathophysiological relevance and relationship to exercise performance. Circulation. 1995;91:2769–2774.[Abstract/Free Full Text]

50. Chua TP, Ponikowski P, Harrington D, et al. Clinical correlates and prognostic significance of the ventilatory response to exercise in chronic heart failure. J Am Coll Cardiol. 1997;29:1585–1590.[Abstract]

This article has been cited by other articles:

				P. Laveneziana, D. E. O'Donnell, D. Ofir, P. Agostoni, L. Padeletti, G. Ricciardi, P. Palange, R. Duranti, and G. Scano Effect of biventricular pacing on ventilatory and perceptual responses to exercise in patients with stable chronic heart failure J Appl Physiol, May 1, 2009; 106(5): 1574 - 1583. [Abstract] [Full Text] [PDF]

				D. Magri, M. Brioschi, C. Banfi, J. P. Schmid, P. Palermo, M. Contini, A. Apostolo, M. Bussotti, E. Tremoli, S. Sciomer, et al. Circulating Plasma Surfactant Protein Type B as Biological Marker of Alveolar-Capillary Barrier Damage in Chronic Heart Failure Circ Heart Fail, May 1, 2009; 2(3): 175 - 180. [Abstract] [Full Text] [PDF]

				B. Koch, C. Schaper, T. Ittermann, T. Spielhagen, M. Dorr, H. Volzke, C. F. Opitz, R. Ewert, and S. Glaser Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP study Eur. Respir. J., February 1, 2009; 33(2): 389 - 397. [Abstract] [Full Text] [PDF]

				H. Ukkonen, I. G. Burwash, W. Dafoe, R. A. de Kemp, H. Haddad, K. Yoshinaga, R. A. Davies, E. K. Gannon, J. N. DaSilva, and R. S.B. Beanlands Is ventilatory efficiency (VE/VCO2 slope) associated with right ventricular oxidative metabolism in patients with congestive heart failure? Eur J Heart Fail, November 1, 2008; 10(11): 1117 - 1122. [Abstract] [Full Text] [PDF]

				J. L. Fleg Improving Exercise Tolerance in Chronic Heart Failure: A Tale of Inspiration? J. Am. Coll. Cardiol., April 29, 2008; 51(17): 1672 - 1674. [Full Text] [PDF]

				L. Ingle, K. K. Witte, J. G.F. Cleland, and A. L. Clark Combining the ventilatory response to exercise and peak oxygen consumption is no better than peak oxygen consumption alone in predicting mortality in chronic heart failure Eur J Heart Fail, January 1, 2008; 10(1): 85 - 88. [Abstract] [Full Text] [PDF]

				K. Albouaini, M. Egred, A. Alahmar, and D. J. Wright Cardiopulmonary exercise testing and its application Postgrad. Med. J., November 1, 2007; 83(985): 675 - 682. [Abstract] [Full Text] [PDF]

				K Albouaini, M Egred, A Alahmar, and D J Wright Cardiopulmonary exercise testing and its application Heart, October 1, 2007; 93(10): 1285 - 1292. [Abstract] [Full Text] [PDF]

				E. A. Jankowska, T. Witkowski, B. Ponikowska, K. Reczuch, L. Borodulin-Nadzieja, S. D. Anker, M. F. Piepoli, W. Banasiak, and P. Ponikowski Excessive ventilation during early phase of exercise: A new predictor of poor long-term outcome in patients with chronic heart failure Eur J Heart Fail, October 1, 2007; 9(10): 1024 - 1031. [Abstract] [Full Text] [PDF]

				M. Guazzi, R. Raimondo, M. Vicenzi, R. Arena, C. Proserpio, S. Sarzi Braga, and R. Pedretti Exercise oscillatory ventilation may predict sudden cardiac death in heart failure patients. J. Am. Coll. Cardiol., July 24, 2007; 50(4): 299 - 308. [Abstract] [Full Text] [PDF]

				R. Arena, J. Myers, M. A. Williams, M. Gulati, P. Kligfield, G. J. Balady, E. Collins, and G. Fletcher Assessment of Functional Capacity in Clinical and Research Settings: A Scientific Statement From the American Heart Association Committee on Exercise, Rehabilitation, and Prevention of the Council on Clinical Cardiology and the Council on Cardiovascular Nursing Circulation, July 17, 2007; 116(3): 329 - 343. [Full Text] [PDF]

				K. Wasserman, X.-G. Sun, and J. E. Hansen Effect of Biventricular Pacing on the Exercise Pathophysiology of Heart Failure Chest, July 1, 2007; 132(1): 250 - 261. [Abstract] [Full Text] [PDF]

				R. Fraga, F. G. Franco, F. Roveda, L. N.J. de Matos, A. M.F.W. Braga, M. U.P.B. Rondon, D. R. Rotta, P. C. Brum, A. C.P. Barretto, H. R. Middlekauff, et al. Exercise training reduces sympathetic nerve activity in heart failure patients treated with carvedilol Eur J Heart Fail, June 1, 2007; 9(6-7): 630 - 636. [Abstract] [Full Text] [PDF]

				M. Metra, P. Ponikowski, K. Dickstein, J. J.V. McMurray, A. Gavazzi, C.-H. Bergh, A. G. Fraser, T. Jaarsma, A. Pitsis, P. Mohacsi, et al. Advanced chronic heart failure: A position statement from the Study Group on Advanced Heart Failure of the Heart Failure Association of the European Society of Cardiology Eur J Heart Fail, June 1, 2007; 9(6-7): 684 - 694. [Abstract] [Full Text] [PDF]

				R. Arena, J. Myers, J. Abella, M. A. Peberdy, D. Bensimhon, P. Chase, and M. Guazzi Development of a Ventilatory Classification System in Patients With Heart Failure Circulation, May 8, 2007; 115(18): 2410 - 2417. [Abstract] [Full Text] [PDF]

				A. Vazir, P.C. Hastings, M. Dayer, H.F. McIntyre, M.Y. Henein, P.A. Poole-Wilson, M.R. Cowie, M.J. Morrell, and A.K. Simonds A high prevalence of sleep disordered breathing in men with mild symptomatic chronic heart failure due to left ventricular systolic dysfunction Eur J Heart Fail, March 1, 2007; 9(3): 243 - 250. [Abstract] [Full Text] [PDF]

				D. Habedank, R. Ewert, M. Hummel, R. Wensel, R. Hetzer, and S. D. Anker Changes in exercise capacity, ventilation, and body weight following heart transplantation Eur J Heart Fail, March 1, 2007; 9(3): 310 - 316. [Abstract] [Full Text] [PDF]

				R. V. Milani, C. J. Lavie, M. R. Mehra, and H. O. Ventura Understanding the Basics of Cardiopulmonary Exercise Testing Mayo Clin. Proc., December 1, 2006; 81(12): 1603 - 1611. [Abstract] [Full Text] [PDF]

				P. Agostoni, M. Contini, A. Magini, A. Apostolo, G. Cattadori, M. Bussotti, F. Veglia, D. Andreini, and P. Palermo Carvedilol reduces exercise-induced hyperventilation: A benefit in normoxia and a problem with hypoxia Eur J Heart Fail, November 1, 2006; 8(7): 729 - 735. [Abstract] [Full Text] [PDF]

				K. Dimopoulos, D. O. Okonko, G.-P. Diller, C. S. Broberg, T. V. Salukhe, S. V. Babu-Narayan, W. Li, A. Uebing, S. Bayne, R. Wensel, et al. Abnormal Ventilatory Response to Exercise in Adults With Congenital Heart Disease Relates to Cyanosis and Predicts Survival Circulation, June 20, 2006; 113(24): 2796 - 2802. [Abstract] [Full Text] [PDF]

				S. N. Nanas, J. N. Nanas, D. Ch. Sakellariou, S. K. Dimopoulos, S. G. Drakos, S. G. Kapsimalakou, C. A. Mpatziou, O. G. Papazachou, A. S. Dalianis, M. I. Anastasiou-Nana, et al. VE/VCO2 slope is associated with abnormal resting haemodynamics and is a predictor of long-term survival in chronic heart failure Eur J Heart Fail, June 1, 2006; 8(4): 420 - 427. [Abstract] [Full Text] [PDF]

				M. Kindermann, B. Hennen, J. Jung, J. Geisel, M. Bohm, and G. Frohlig Biventricular Versus Conventional Right Ventricular Stimulation for Patients With Standard Pacing Indication and Left Ventricular Dysfunction: The Homburg Biventricular Pacing Evaluation (HOBIPACE) J. Am. Coll. Cardiol., May 16, 2006; 47(10): 1927 - 1937. [Abstract] [Full Text] [PDF]

				L. C. Davies, R. Wensel, P. Georgiadou, M. Cicoira, A. J.S. Coats, M. F. Piepoli, and D. P. Francis Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failure by non-linear analysis: oxygen uptake efficiency slope Eur. Heart J., March 2, 2006; 27(6): 684 - 690. [Abstract] [Full Text] [PDF]

				V. Regitz-Zagrosek, B. Hocher, M. Bettmann, M. Brede, K. Hadamek, C. Gerstner, H. B. Lehmkuhl, R. Hetzer, and L. Hein {alpha}2C-Adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy Eur. Heart J., February 2, 2006; 27(4): 454 - 459. [Abstract] [Full Text] [PDF]

				R. Arena, J. Myers, J. Abella, and M. A. Peberdy Influence of Heart Failure Etiology on the Prognostic Value of Peak Oxygen Consumption and Minute Ventilation/Carbon Dioxide Production Slope Chest, October 1, 2005; 128(4): 2812 - 2817. [Abstract] [Full Text] [PDF]

				M. Guazzi, G. Reina, G. Tumminello, and M. D. Guazzi Alveolar-capillary membrane conductance is the best pulmonary function correlate of exercise ventilation efficiency in heart failure patients Eur J Heart Fail, October 1, 2005; 7(6): 1017 - 1022. [Abstract] [Full Text] [PDF]

				C. F. Opitz, R. Wensel, J. Winkler, M. Halank, L. Bruch, F.-X. Kleber, G. Hoffken, S. D. Anker, A. Negassa, S. B. Felix, et al. Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension Eur. Heart J., September 2, 2005; 26(18): 1895 - 1902. [Abstract] [Full Text] [PDF]

				P. Agostoni, M. Bianchi, A. Moraschi, P. Palermo, G. Cattadori, R. La Gioia, M. Bussotti, and K. Wasserman Work-rate affects cardiopulmonary exercise test results in heart failure Eur J Heart Fail, June 1, 2005; 7(4): 498 - 504. [Abstract] [Full Text] [PDF]

				M. Wonisch, P. Lercher, D. Scherr, R. Maier, R. Pokan, P. Hofmann, and S. P. von Duvillard Influence of Permanent Right Ventricular Pacing on Cardiorespiratory Exercise Parameters in Chronic Heart Failure Patients With Implanted Cardioverter Defibrillators Chest, March 1, 2005; 127(3): 787 - 793. [Abstract] [Full Text] [PDF]

				M. Arzt, M. Schulz, R. Wensel, S. Montalvan, F. C. Blumberg, G. A. J. Riegger, and M. Pfeifer Nocturnal Continuous Positive Airway Pressure Improves Ventilatory Efficiency During Exercise in Patients With Chronic Heart Failure Chest, March 1, 2005; 127(3): 794 - 802. [Abstract] [Full Text] [PDF]

				M. Guazzi, G. Reina, G. Tumminello, and M. D. Guazzi Exercise ventilation inefficiency and cardiovascular mortality in heart failure: the critical independent prognostic value of the arterial CO2 partial pressure Eur. Heart J., March 1, 2005; 26(5): 472 - 480. [Abstract] [Full Text] [PDF]

				F. J. Meyer, D. Lossnitzer, A. V. Kristen, A. M. Schoene, W. Kubler, H. A. Katus, and M. M. Borst Respiratory muscle dysfunction in idiopathic pulmonary arterial hypertension Eur. Respir. J., January 1, 2005; 25(1): 125 - 130. [Abstract] [Full Text] [PDF]

				U. Corra, A. Mezzani, E. Bosimini, and P. Giannuzzi Cardiopulmonary Exercise Testing and Prognosis in Chronic Heart Failure*: A Prognosticating Algorithm for the Individual Patient Chest, September 1, 2004; 126(3): 942 - 950. [Abstract] [Full Text] [PDF]

				F. X. Kleber The predictive value of cardiorespiratory fitness Eur. Heart J., August 2, 2004; 25(16): 1374 - 1375. [Full Text] [PDF]

				H. T. Robertson, R. Pellegrino, D. Pini, J. Oreglia, S. DeVita, V. Brusasco, and P. Agostoni Exercise response after rapid intravenous infusion of saline in healthy humans J Appl Physiol, August 1, 2004; 97(2): 697 - 703. [Abstract] [Full Text] [PDF]

				F.X Kleber, P Waurick, and M Winterhalter CPET in heart failure Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D1 - D4. [Abstract] [Full Text] [PDF]

				B. Lamp, J. Vogt, H. Schmidt, and D. Horstkotte Impact of cardiopulmonary exercise testing on patient selection for cardiac resynchronisation therapy Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D5 - D9. [Abstract] [Full Text] [PDF]

				R. V. Milani, C. J. Lavie, and M. R. Mehra Cardiopulmonary Exercise Testing: How Do We Differentiate the Cause of Dyspnea? Circulation, July 27, 2004; 110(4): e27 - e31. [Full Text] [PDF]

				P. Agostoni, G. Cattadori, M. Bianchi, and K. Wasserman Exercise-Induced Pulmonary Edema in Heart Failure Circulation, November 25, 2003; 108(21): 2666 - 2671. [Abstract] [Full Text] [PDF]

				R. Wolk, B. D. Johnson, and V. K. Somers Leptin and the ventilatory response to exercise in heart failure J. Am. Coll. Cardiol., November 5, 2003; 42(9): 1644 - 1649. [Abstract] [Full Text] [PDF]

				R. Arena, J. Myers, S. S. Aslam, E. B. Varughese, and M. A. Peberdy Technical Considerations Related to the Minute Ventilation/Carbon Dioxide Output Slope in Patients With Heart Failure Chest, August 1, 2003; 124(2): 720 - 727. [Abstract] [Full Text] [PDF]

				S Sakurai, H Adachi, A Hasegawa, H Hoshizaki, S Oshima, K Taniguchi, and M Kurabayashi Brain natriuretic peptide facilitates severity classification of stable chronic heart failure with left ventricular dysfunction Heart, June 1, 2003; 89(6): 661 - 662. [Full Text] [PDF]

				M. Arzt, M. Harth, A. Luchner, F. Muders, S. R. Holmer, F. C. Blumberg, G. A.J. Riegger, and M. Pfeifer Enhanced Ventilatory Response to Exercise in Patients With Chronic Heart Failure and Central Sleep Apnea Circulation, April 22, 2003; 107(15): 1998 - 2003. [Abstract] [Full Text] [PDF]

				T Tomita, H Takaki, Y Hara, F Sakamaki, T Satoh, S Takagi, Y Yasumura, N Aihara, Y Goto, and K Sunagawa Attenuation of hypercapnic carbon dioxide chemosensitivity after postinfarction exercise training: possible contribution to the improvement in exercise hyperventilation Heart, April 1, 2003; 89(4): 404 - 410. [Abstract] [Full Text] [PDF]

				C. Varma, S. Sharma, S. Firoozi, W. J. McKenna, J.-C. Daubert, and Multisite Stimulation in Cardiomyopathy (MUSTIC) S Atriobiventricular pacing improves exercise capacity in patients with heart failure and intraventricular conduction delay J. Am. Coll. Cardiol., February 19, 2003; 41(4): 582 - 588. [Abstract] [Full Text] [PDF]

				A. K. Gitt, K. Wasserman, C. Kilkowski, T. Kleemann, A. Kilkowski, M. Bangert, S. Schneider, A. Schwarz, and J. Senges Exercise Anaerobic Threshold and Ventilatory Efficiency Identify Heart Failure Patients for High Risk of Early Death Circulation, December 10, 2002; 106(24): 3079 - 3084. [Abstract] [Full Text] [PDF]

				P. Agostoni, M. Guazzi, M. Bussotti, S. De Vita, and P. Palermo Carvedilol Reduces the Inappropriate Increase of Ventilation During Exercise in Heart Failure Patients Chest, December 1, 2002; 122(6): 2062 - 2067. [Abstract] [Full Text] [PDF]

				X.-G. Sun, J. E. Hansen, N. Garatachea, T. W. Storer, and K. Wasserman Ventilatory Efficiency during Exercise in Healthy Subjects Am. J. Respir. Crit. Care Med., December 1, 2002; 166(11): 1443 - 1448. [Abstract] [Full Text] [PDF]

				M Mejhert, E Linder-Klingsell, M Edner, T Kahan, and H Persson Ventilatory variables are strong prognostic markers in elderly patients with heart failure Heart, September 1, 2002; 88(3): 239 - 243. [Abstract] [Full Text] [PDF]

				D.P. Nicholls, C. O'Dochartaigh, and M.S. Riley Circulatory power--a new perspective on an old friend Eur. Heart J., August 2, 2002; 23(16): 1242 - 1245. [PDF]

				R. Wensel, C. F. Opitz, S. D. Anker, J. Winkler, G. Hoffken, F. X. Kleber, R. Sharma, M. Hummel, R. Hetzer, and R. Ewert Assessment of Survival in Patients With Primary Pulmonary Hypertension: Importance of Cardiopulmonary Exercise Testing Circulation, July 16, 2002; 106(3): 319 - 324. [Abstract] [Full Text] [PDF]

				X.-G. Sun, J. E. Hansen, R. J. Oudiz, and K. Wasserman Gas Exchange Detection of Exercise-Induced Right-to-Left Shunt in Patients With Primary Pulmonary Hypertension Circulation, January 1, 2002; 105(1): 54 - 60. [Abstract] [Full Text] [PDF]

				C. Zugck, C. Kruger, R. Kell, S. Korber, D. Schellberg, W. Kubler, and M. Haass Risk stratification in middle-aged patients with congestive heart failure: prospective comparison of the Heart Failure Survival Score (HFSS) and a simplified two-variable model Eur J Heart Fail, October 1, 2001; 3(5): 577 - 585. [Abstract] [Full Text] [PDF]

				C. C.W. Hsia Coordinated Adaptation of Oxygen Transport in Cardiopulmonary Disease Circulation, August 21, 2001; 104(8): 963 - 969. [Full Text] [PDF]

				P. Ponikowski, T. P. Chua, S. D. Anker, D. P. Francis, W. Doehner, W. Banasiak, P. A. Poole-Wilson, M. F. Piepoli, and A. J.S. Coats Peripheral Chemoreceptor Hypersensitivity: An Ominous Sign in Patients With Chronic Heart Failure Circulation, July 31, 2001; 104(5): 544 - 549. [Abstract] [Full Text] [PDF]

				X.-G. Sun, J. E. Hansen, R. J. Oudiz, and K. Wasserman Exercise Pathophysiology in Patients With Primary Pulmonary Hypertension Circulation, July 24, 2001; 104(4): 429 - 435. [Abstract] [Full Text] [PDF]

				L TAVAZZI and P GIANNUZZI Physical training as a therapeutic measure in chronic heart failure: time for recommendations Heart, July 1, 2001; 86(1): 7 - 11. [Full Text] [PDF]

				D P Francis, L C Davies, and A J S Coats Diagnostic exercise physiology in chronic heart failure Heart, July 1, 2001; 86(1): 17 - 20. [Full Text] [PDF]

				A. L. Clark, F. X. Kleber, G. Vietzke, K.-D. Wernecke, U. Bauer, C. Opitz, R. Wensel, A. Sperfeld, and S. Glaser Impairment of Ventilatory Efficiency in Heart Failure Response Circulation, May 8, 2001; 103 (18): e97 - e97. [Full Text] [PDF]

				R. L. Johnson Jr Gas Exchange Efficiency in Congestive Heart Failure II Circulation, February 20, 2001; 103(7): 916 - 918. [Full Text] [PDF]

				R. L. Johnson Jr Gas Exchange Efficiency in Congestive Heart Failure Circulation, June 20, 2000; 101(24): 2774 - 2776. [Full Text] [PDF]

This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kleber, F. X. Articles by Gläser, S. Search for Related Content PubMed PubMed Citation Articles by Kleber, F. X. Articles by Gläser, S. Related Collections Congestive Exercise testing