(Circulation. 2000;102:III-142.)
© 2000 American Heart Association, Inc.
Surgery for Congenital Heart Disease |
From the Great Ormond Street Hospital for Children NHS Trust and the Royal Brompton and Harefield NHS Trust (S.Y.H., A.B., M.R., R.C.F.), London, England.
Correspondence to Dr D.J. Penny, Cardiothoracic Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK WC1. E-mail dan.penny{at}gosh-tr.nthames.nhs.uk
| Abstract |
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Methods and ResultsThe clinical course and preoperative angiograms of patients who underwent unifocalization were reviewed. Patients who developed airflow limitation early after surgery underwent fiberoptic bronchoscopy. In addition, the anatomy of the MAPCAs was examined in 14 heart-lung blocks from patients with PA-VSD. Twenty-two procedures were performed in 16 children. Three developed marked airflow limitation early after surgery, necessitating prolonged high-pressure ventilation. Bronchoscopy demonstrated tracheobronchial epithelial necrosis in 2 and signs of tracheobronchial ischemia in the third. Two were successfully extubated after 15 and 16 days, but the third died after 57 days of ventilatory support. Review of the preoperative angiograms demonstrated an extensive peribronchial arterial supply arising from a MAPCA in 1 of the patients who developed severe airway necrosis after unifocalization. This was also obvious in a second patient, but the MAPCA was not included in the unifocalization. In 7 autopsy specimens, MAPCAs contributed to a peribronchial or peritracheal vascular network. Dissection of the distribution of these branches in 2 specimens revealed extensive intrapulmonary peribronchial anastomoses.
ConclusionsAirflow limitation early after unifocalization is related to airway ischemia resulting from interruption of the tracheobronchial blood supply during mobilization of MAPCAs.
Key Words: heart defects, congenital surgery ventilation complications
| Introduction |
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The pathophysiological basis for airflow limitation early after unifocalization is unknown. The refractory nature of this phenomenon makes it likely that processes other than classic "bronchospasm" are responsible for its development. In this article, we provide a clinical-morphological assessment of patients with pulmonary atresia and ventricular septal defect who underwent a unifocalization procedure, with particular reference to the pathogenesis of airflow limitation.
| Methods |
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Fiberoptic Bronchoscopy
In these 3 patients who developed airflow limitation, we performed
fiberoptic bronchoscopy to ascertain the mechanism for the airflow
limitation. As will be discussed, these examinations demonstrated
appearances consistent with severe airway ischemia.
Review of Angiograms
To delineate the vascular supply of the proximal
tracheobronchial tree in our group, we reviewed the preoperative
angiograms of all 16 patients. The number, origin, course, and distal
blood supply of the MAPCAs were noted, with particular attention given
to any supply from them to the tracheobronchial tree.
Pathological Correlation
We dissected a series of stored heart-lung blocks of 14 patients
with pulmonary atresia and ventricular septal
defect. We examined only those hearts in which atresia of the
pulmonary trunk was found in association with concordant AV
connections and in which the great arteries were "normally
related," with the aorta posterior and to the right of the remnant of
the pulmonary trunk. We paid particular attention to the
pulmonary vascular supply and to the course of the MAPCAs on
the basis of the normal bronchopulmonary segments and their
relationship to the tracheobronchial tree. In 2 cases, it was possible
to perform a detailed dissection of small peribronchial anastomoses
that arose from distal branches of the MAPCAs.
| Results |
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In 19 procedures, the MAPCAs were connected to each other and then to
an expanded polytetrafluoroethylene (PTFE)
shunt (range, 3.5 to 6 mm) that was anastomosed to the subclavian
artery7 (Figure 1
). In 2
cases, the mobilized azygous vein was used to augment the anastomosis
between collaterals,11 and in 1 case, the MAPCAs were
unifocalized to the already shunted central pulmonary artery.
In 1 patient, the unifocalization was performed as part of a complete
correction. Significant postoperative complications included chylous
pleural effusion (n=1), pneumonia (n=1),
hemothorax requiring surgical exploration (n=1), and phrenic nerve
palsy (n=3), and 3 patients experienced severe airflow limitation with
expiratory wheeze and signs of air trapping resembling bronchospasm,
necessitating ventilation with high inspiratory pressures (peak
inspiratory pressure >30 cm H2O), prolonged
expiratory time to prevent autopositive end-expiratory pressure (as
measured from online ventilatory flow-pressure studies), and
hypoxia requiring oxygen supplementation. All were unresponsive
to bronchodilator therapy, inhaled nitric oxide, and steroids. Compared
with the patients without airflow limitation in whom the median
duration of ventilatory support was 2.1 days, 2 patients with airflow
limitation required 15 and 16 days of ventilation, and 1 patient died
after 57 days of ventilatory support. Consent for postmortem
examination of this patient was refused. The other 2 survivors of
severe airflow limitation were in good health on follow-up without
symptoms of residual airflow obstruction.
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Fiberoptic Bronchoscopy
In the 3 patients with airflow limitation, bronchoscopy
demonstrated extensive necrosis of the trachea and main bronchi with
sloughing of the mucosa, resulting in severe airway obstruction in 2
patients (Figure 2
). In the third patient
with less severe disease, there was severe mucosal pallor, suggesting
ischemia and minor mucosal sloughing.
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Review of Preoperative Angiograms
In all, the courses of 48 MAPCAs were studied (Table 1
).
These originated from the descending aorta (81%) or the right or left
subclavian artery (19%). In 2 patients (patients 2 and 16), an MAPCA
was seen to supply an extensive peribronchial network (Figure 3
, top and bottom). One of these patients
developed severe airway necrosis in the postoperative period after this
MAPCA was unifocalized; in the second patient, the MAPCA was not
included in the unifocalization procedure.
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Postmortem Specimens
In the 14 patients in whom autopsy specimens were studied (Table 2
), the age at death ranged from 0.1 to
39.8 years (median, 2.9 years). Five had died in the early
postoperative period. The clinical notes described airflow limitation
and desaturation in 2 patients, with early postoperative bronchoscopy
demonstrating marked edema of the right main bronchus and its branches,
causing airway obstruction and right upper lung collapse in 1 patient
(patient 5) who died of pericardial tamponade 5 weeks later, and signs
of submucosal hemorrhage of the left main bronchus and its
branches in the autopsy specimen of the other patient (patient 8).
Forty-four MAPCAs were identified, and their courses were
analyzed. Eight were found to contribute to a peribronchial or
peritracheal vascular network (Figure 4
, top), and careful dissection of distal branches of these collaterals in
2 specimens revealed the occurrence of extensive intrapulmonary
bronchomucosal anastomoses (Figure 4
, bottom).
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| Discussion |
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Unifocalization procedures have been developed for the treatment of patients with multiple sources of pulmonary blood supply. The precise surgical technique, in particular, whether a central or lateral approach should be undertaken, remains controversial. In most of our patients, a lateral approach was used that generally involved ligation and mobilization of collaterals. In most patients, this required minimal extrahilar dissection of the collateral arteries, but in some, it was necessary to dissect distally into the lung parenchyma.
Three patients developed severe airflow limitation, a similar proportion to that seen in other series.8 9 Superficially, the clinical appearance was similar to classic bronchospasm, and increased airway reactivity with bronchospasm has been reported in patients with pulmonary atresia and hypoplastic pulmonary arteries.12 However, as previously observed, it was refractory to treatment with bronchodilator therapies in our patients.11 One patient had airflow limitation of such severity that she died after prolonged intensive care. In other reports, the morbidity and mortality for this disease process have been considerable. In one series, it was described in 3 of 4 patients with prolonged ventilatory requirements,8 and in another series, it was the cause of 2 of 3 early postoperative deaths.9
Fiberoptic bronchoscopy demonstrated that in our patients, the airflow limitation was related not to bronchospasm but to severe airway necrosis, suggesting that the nutritive supply to the airway epithelium was compromised by the unifocalization procedure and that other mechanisms for unresponsiveness to bronchodilators, such as lymphatic flow interruption13 or denervation hypersensitivity,14 were therefore unlikely. A review of the preoperative angiograms and careful dissection of a series of postmortem specimens demonstrated that in some patients with pulmonary atresia, ventricular septal defect, and MAPCAs, extensive vascular networks arise from the collateral arteries that provide significant blood flow to the large airways.
In normal subjects, there are multiple small systemic arteries that serve a nutritive role to the lungs. In addition, there are 3 to 4 recognizable bronchial arteries: 2 supplying the left lung and 1 to 2 supplying the right lung.4 It is widely considered that in patients with pulmonary atresia and ventricular septal defect, at least some major aortopulmonary collaterals have an embryological origin from these bronchial arteries.3 5 However, it has been suggested that in these patients, the collaterals have lost their nutritive role to the lungs, being functionally "pulmonary" rather than "bronchial."5 15 16 This assumption is based on the hypothesis that collateral arteries join the pulmonary arterial circulation at the hila or within the lungs before reaching the respiratory units and proximal to the origin of any nutritive end arteries. However, more recent anatomic descriptions1 6 17 and our own observations in this study bring this view into question and demonstrate that collateral arteries may give branches to the tracheobronchial tree before they anastomose with the peripheral pulmonary circulation. Thus, the major aortopulmonary collaterals not only may be pulmonary in function but also may have an important bronchial role and nutritive component to the tracheobronchial tree. The precise anatomy of the MAPCA needs to be delineated with selective high-resolution angiography, which may require pressurized injections of contrast material into each of the target collaterals to overcome wash-in/washout phenomena and the potentially higher resistance to blood flow to the peribronchial network compared with the lung parenchyma. If such a peribronchial network originating from a specific collateral can be demonstrated, then the subsequent surgical technique should take this information into account to avoid damage to the tracheobronchial arterial supply and to obviate the morbidity and mortality associated with tracheobronchial ischemia.
In summary, our data suggest that careful preoperative and intraoperative attention must be paid to the potential nutritive role of each MAPCA in patients in whom unifocalization is considered. If after the unifocalization procedure such patients develop signs of airflow limitation that is unresponsive to standard bronchodilator treatment, prompt bronchoscopy should be performed.
| Acknowledgments |
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| References |
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