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(Circulation. 2001;103:e62.)
© 2001 American Heart Association, Inc.

Images in Cardiovascular Medicine

Four-Dimensional Cardiac Imaging With Multislice Computed Tomography

Koen Nieman, MD; Peter van Ooijen, MSc; Benno Rensing, MD, PhD; Matthijs Oudkerk, MD, PhD; Pim J. de Feyter, MD, PhD

From the Department of Cardiology, Thoraxcenter (K.N., B.R., P.J.d.F.), and Department of Radiology, Daniel den Hoed Clinic (P.v.O., M.O.), Rotterdam University Hospital, Rotterdam, Netherlands.

A 58-year-old man was referred to our center for angiographic evaluation of unstable anginal complaints. Selective coronary angiography revealed 3-vessel disease.

Multislice CT angiography (Somatom plus 4 Volume Zoom, Siemens AG), a new noninvasive technique to image the heart and coronary arteries, was also performed (Figure). The entire heart was scanned within 1 single breath-hold after injection of a contrast medium (iomeprol, 350 mg/mL, 144 mL at 4 mL/s). By use of retrograde ECG gating, a 3D volume consisting of thin slices can be reconstructed from the CT data during a preselected period (250 ms) within the RR interval of each cardiac cycle. 3D data sets were acquired during 20 different reconstruction intervals equally distributed throughout the cardiac cycle.

View larger version (166K): [in this window] [in a new window]   Figure 1. Selective coronary angiogram of left coronary artery (90° left anterior oblique view). Midsegment of left anterior descending coronary artery (LAD, arrowheads) and proximal circumflex artery are occluded and distal parts are filled by collateral vessels. Significant lesions can be observed in second diagonal branch (D2, arrow) as well.

These 20 3D data sets, each representing a different cardiac phase, were further processed on a graphic work-station (Indigo 2, SGI) with 3D volume-rendering software (Voxel View, Vital Images). By manual segmentation, the thoracic wall was removed from each volume. From these volumes, a large series of movie frames was recorded, like photographs, and ordered according to their phase. By running these frames at a speed corresponding to the original heart rate, we could create a 4D representation of the beating heart (Movie).

Footnotes

Reprint requests to Koen Nieman, MD, Catheterization Laboratory, Thoraxcenter BD 406, PO Box 2040, 3000 CA Rotterdam, Netherlands.

Movie can be found Online at www.circulationaha.org

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This Article Extract Full Text (PDF) Data Supplement Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nieman, K. Articles by de Feyter, P. J. Search for Related Content PubMed PubMed Citation Articles by Nieman, K. Articles by de Feyter, P. J. Related Collections Contractile function Cardiovascular imaging agents/Techniques Imaging CT and MRI