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This item has the following additional materials available:
Figures I through III (Powerpoint files)
Figure I. Ischemia with selective perfusion of posterior papillary muscle (PM). Ischemia of the inferior base was produced by ligating the proximal portion of the left circumflex coronary artery. Papillary muscle blood flow was maintained with a salvage perfusion catheter supplying blood more distally. The catheter was then removed to infarct the papillary muscle as well. OM = obtuse marginal.
Figure II. MR stroke volume vs Tethering length. A and B: Parallel variations in MR stroke volume and axial component of tethering length. C: Non-linear relationship between MR and tethering length, with a steeper rise in MR as tethering increased, suggesting that a normal excess of leaflet area is being used up. MI = myocardial infarction.
Figure III. Sheep with mitral valve prolapse. Left: Baseline prolapse and MR. Middle: Inferior ischemia tethered the leaflets back into the LV and reduced MR. Right: Adding papillary muscle ischemia allowed the muscles to elongate, with recurrent prolapse and MR.
Prepared by: the Data Supplement Manager
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