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Circulation. 2005;111:3185

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(Circulation. 2005;111:3185.)
© 2005 American Heart Association, Inc.

Issue Highlights


*    HYPOTHERMIA IMPROVES DEFIBRILLATION SUCCESS AND RESUSCITATION OUTCOMES FROM VENTRICULAR FIBRILLATION, by Boddicker et al.
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*HYPOTHERMIA IMPROVES...
down arrowIMPACT OF PROSTHESIS-PATIENT...
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Mild hypothermia (32°C to 35°C) improves neurological outcome in patients with coma after resuscitation from ventricular fibrillation. However, hypothermia itself can cause ventricular fibrillation, and its implementation is believed to be contraindicated when life-threatening arrhythmias continue. This study examined the effects of hypothermia on restoration of circulation after 8 minutes of ventricular fibrillation in swine. Hypothermia implemented before arrest improved the success of defibrillation and resuscitation. These findings suggest that, in addition to neurological benefits, hypothermia may have cardiac benefits in some situations. Further studies of hypothermia during cardiac arrest are warranted. See p 3195.


*    IMPACT OF PROSTHESIS–PATIENT SIZE ON FUNCTIONAL RECOVERY AFTER AORTIC VALVE REPLACEMENT, by Koch et al.
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Functional recovery after aortic valve replacement is a key goal in addition to informed survival. Controversy remains with regard to the impact of a small-sized prosthesis implanted into a large and physically active patient. This study of more than 1000 patients early after aortic valve replacement documents similar functional recovery for the full spectrum of aortic valve sizes indexed to the body size of the patient. These data suggest that factors other than prosthesis-patient mismatch may be responsible for the adverse influences on functional recovery and quality of life. See p 3221.


*    MAGNITUDE OF AND RISK FACTORS FOR IN-HOSPITAL AND POSTDISCHARGE STROKE IN PATIENTS WITH ACUTE CORONARY SYNDROMES: FINDINGS FROM A GLOBAL REGISTRY OF ACUTE CORONARY EVENTS, by Budaj et al.
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This report by Budaj et al involves 35 233 patients with an acute coronary syndrome (ACS) admitted to 94 hospitals in 14 countries between April 1999 and December 2003 as part of the GRACE Registry. A total of 579 patients (1.6%) experienced a stroke between hospital admission and 6 months after discharge (310 in hospital; 269 after discharge). Risk factors for in-hospital and postdischarge strokes are described by the authors. Despite the relatively low incidence of stroke in ACS patients, it is an important predictor of mortality and morbidity. Large-scale observational studies such as the one from GRACE are important for providing contemporary estimates of the incidence of stroke and risk factors for its development and underscore the need for continued research to minimize the development of stroke when patients present with ACS. See p 3242.


*    Visit http://www.circ.ahajournals.org:
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Clinician Update
Symptoms Other Than Chest Pain May Be Important in the Diagnosis of "Silent Ischemia," or "The Sounds of Silence." See p e435.

Images in Cardiovascular Medicine
Free-Floating Thrombus in Right Heart and Massive Pulmonary Embolism Migrating Into Pulmonary Artery. See p e438.

Giant Coronary Artery Aneurysms in Kawasaki disease. See p e440.



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Anomalous Coronary Anatomy. See p e441.

Correspondence
See p e442.


Related Articles:

Symptoms Other Than Chest Pain May Be Important in the Diagnosis of "Silent Ischemia," or "The Sounds of Silence"
Shlomo Stern
Circulation 2005 111: e435-e437. [Extract] [Full Text]

Free-Floating Thrombus in Right Heart and Massive Pulmonary Embolism Migrating Into Pulmonary Artery
Yoshihiro Noji, Tohru Kojima, Takahiko Aoyama, Masato Yamaguchi, Tsutomu Araki, Susumu Fujino, Katsuaki Yokota, Noriko Kumamoto, Takakiyo Nakaya, Keiichiro Takase, Masami Shimizu, and Hiroshi Mabuchi
Circulation 2005 111: e438-e439. [Extract] [Full Text]

Giant Coronary Artery Aneurysms in Kawasaki Disease
Christian Lilje and James J. Joyce
Circulation 2005 111: e440. [Extract] [Full Text]

Anomalous Coronary Anatomy
Scott C. Turner, D. Scott Gantt, and Dan Giebel
Circulation 2005 111: e441. [Extract] [Full Text]

Letter Regarding Article by Argaud et al, "Postconditioning Inhibits Mitochondrial Permeability Transition"
Heberty T.F. Facundo, Alicia J. Kowaltowski, Laurent Argaud, Odile Gateau-Roesch, Olivier Raisky, Joseph Loufouat, Michel Ovize, and Dominique Robert
Circulation 2005 111: e442. [Extract] [Full Text]

Hypothermia Improves Defibrillation Success and Resuscitation Outcomes From Ventricular Fibrillation
Kimberly A. Boddicker, Yi Zhang, M. Bridget Zimmerman, Loyd R. Davies, and Richard E. Kerber
Circulation 2005 111: 3195-3201. [Abstract] [Full Text]

Impact of Prosthesis–Patient Size on Functional Recovery After Aortic Valve Replacement
Colleen Gorman Koch, Farah Khandwala, Fawzy G. Estafanous, Floyd D. Loop, and Eugene H. Blackstone
Circulation 2005 111: 3221-3229. [Abstract] [Full Text]

Magnitude of and Risk Factors for In-Hospital and Postdischarge Stroke in Patients With Acute Coronary Syndromes: Findings From a Global Registry of Acute Coronary Events
Andrzej Budaj, Katarzyna Flasinska, Joel M. Gore, Frederick A. Anderson, Jr, Omar H. Dabbous, Frederick A. Spencer, Robert J. Goldberg, Keith A.A. Fox for the GRACE Investigators
Circulation 2005 111: 3242-3247. [Abstract] [Full Text]




This Article
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