Circulation. 2005;111:245
(Circulation. 2005;111:245.)
© 2005 American Heart Association, Inc.
Issue Highlights
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PATIENTS WITH DEPRESSIVE SYMPTOMS HAVE LOWER HEALTH STATUS BENEFITS AFTER CORONARY ARTERY BYPASS SURGERY, by Mallik et al.
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Successful CABG surgery leads to improved survival in selected
populations and often dramatic improvement in functional status.
Traditional studies of the risk factors for improvement in functional
status have focused on measures of diseased severity and comorbid
conditions. Mallik et al have studied and documented the impact
of preoperative depression. They found that depression is one
of the strongest predictors of functional status measured 6
months postoperatively. They suggest that pre- and postoperative
treatment of depression be considered to improve the clinical
functional result after CABG surgery. See p
271.
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CHOLESTERYL ESTER TRANSFER PROTEIN TaqIB VARIANT, HIGH-DENSITY LIPOPROTEIN CHOLESTEROL LEVELS, CARDIOVASCULAR RISK, AND EFFICACY OF PRAVASTATIN TREATMENT: INDIVIDUAL PATIENT META-ANALYSIS OF 13677 SUBJECTS, by Boekholdt et al.
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The notion that high-density lipoprotein cholesterol (HDL-C)
is inversely associated with coronary artery disease risk is
firmly established. Moreover, environmental determinants of
HDL-C levels are also well described. Despite this knowledge,
relatively little is known about the genetic determinants of
HDL-C levels and the response to lipid-lowering therapy. The
article in this issue by Boekholdt and colleagues helps bridge
these gaps in knowledge by investigating a common polymorphism
of cholesteryl ester transfer protein in a large, well-characterized
population. They found significant associations between CETP
genotype and HDL-C that were also linked to coronary artery
disease risk. They also provide information on the pharmacogenomic
implications of this CETP polymorphism for statin therapy. See
p
278.
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VASCULAR ENDOTHELIAL DYSFUNCTION AND MORTALITY RISK IN PATIENTS WITH CHRONIC HEART FAILURE, by Katz et al.
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Prior studies have shown that patients with heart failure have
endothelial dysfunction, and this abnormality could contribute
to pathogenesis, symptoms, and long-term outcome. For example,
endothelial dysfunction might increase stiffness of the central
aorta and increase the hemodynamic load on the left ventricle.
In addition, endothelial dysfunction might impair blood flow
to the myocardium and skeletal muscle. In this issue of
Circulation,
Katz and colleagues examined the relation between endothelial
function and prognosis in patients with heart failure. They
observed that patients with impaired flow-mediated dilation
of the brachial artery or decreased levels of exhaled nitric
oxide were more likely to die or require urgent heart transplantation
during a median follow-up period of 396 days. The predictive
value of these measures of endothelial dysfunction remained
significant after adjustment for other known predictors of risk.
These findings provide new information about the clinical importance
of endothelial dysfunction in heart failure patients and may
suggest a pathogenic link. See p
310.
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Visit www.circ.ahajournals.org:
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Clinician Update
Innocent Murmurs. See p
e20.
Images in Cardiovascular Medicine
Klippel-Trenaunay-Weber Syndrome. See p e23. 
Reversible Wall Thinning in Hibernation Predicted by Cardiovascular Magnetic Resonance. See p e24.
Correspondence
See p e26.
Related Articles:
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Patients With Depressive Symptoms Have Lower Health Status Benefits After Coronary Artery Bypass Surgery
- Susmita Mallik, Harlan M. Krumholz, Zhen Qiu Lin, Stanislav V. Kasl, Jennifer A. Mattera, Sarah A. Roumains, and Viola Vaccarino
Circulation 2005 111: 271-277.
[Abstract]
[Full Text]
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Cholesteryl Ester Transfer Protein TaqIB Variant, High-Density Lipoprotein Cholesterol Levels, Cardiovascular Risk, and Efficacy of Pravastatin Treatment: Individual Patient Meta-Analysis of 13 677 Subjects
- S.M. Boekholdt, F.M. Sacks, J.W. Jukema, J. Shepherd, D.J. Freeman, A.D. McMahon, F. Cambien, V. Nicaud, G.J. de Grooth, P.J. Talmud, S.E. Humphries, G.J. Miller, G. Eiriksdottir, V. Gudnason, H. Kauma, S. Kakko, M.J. Savolainen, M. Arca, A. Montali, S. Liu, H.J. Lanz, A.H. Zwinderman, J.A. Kuivenhoven, and J.J.P. Kastelein
Circulation 2005 111: 278-287.
[Abstract]
[Full Text]
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Vascular Endothelial Dysfunction and Mortality Risk in Patients With Chronic Heart Failure
- Stuart D. Katz, Katarzyna Hryniewicz, Ingrid Hriljac, Kujtim Balidemaj, Clarito Dimayuga, Alhakam Hudaihed, and Aleksandr Yasskiy
Circulation 2005 111: 310-314.
[Abstract]
[Full Text]
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Innocent Murmurs
- Thomas Biancaniello
Circulation 2005 111: e20-e22.
[Extract]
[Full Text]
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Klippel-Trenaunay-Weber Syndrome
- Vincent M. Brandenburg, Jürgen Graf, Henning Schubert, and Karl-Christian Koch
Circulation 2005 111: e23.
[Extract]
[Full Text]
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Reversible Wall Thinning in Hibernation Predicted by Cardiovascular Magnetic Resonance
- Anna S. John, Gilles D. Dreyfus, and Dudley J. Pennell
Circulation 2005 111: e24-e25.
[Extract]
[Full Text]
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Letter Regarding Article by Bokhari et al, "Long-Term Comparison of the Implantable Cardioverter Defibrillator Versus Amiodarone: Eleven-Year Follow-Up of a Subset of Patients in the Canadian Implantable Defibrillator Study (CIDS)" • Response
- Giuseppe Boriani, Mauro Biffi, Cristian Martignani, Iqwal Mangat, Fayez Bokhari, David Newman, Mary Greene, Victoria Korley, and Paul Dorian
Circulation 2005 111: e26.
[Extract]
[Full Text]
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