Circulation. 2005;111:533
(Circulation. 2005;111:533.)
© 2005 American Heart Association, Inc.
Issue Highlights
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IMPACT OF REGULAR PHYSICAL ACTIVITY ON THE NAD(P)H OXIDASE AND ANGIOTENSIN RECEPTOR SYSTEM IN PATIENTS WITH CORONARY ARTERY DISEASE, by Adams et al.
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It has long been known that exercise and physical activity contribute
to a healthy lifestyle. Moreover, regular physical activity
tends to promote a favorable lipoprotein profile, manifested
principally as an increase in high-density lipoprotein cholesterol.
As reported in this issue, German investigators have probed
the effect of exercise training on the arterial wall. They found
that regular exercise limited the arterial content of angiotensin
type I receptors and enhanced expression of angiotensin type
II receptors. In concert with these observations, they found
that arterial production of reactive oxygen species was also
significantly reduced by exercise training. In total, these
effects produced an improvement in endothelial function. These
data provide tangible evidence that exercise training has a
direct impact on the vascular wall. See p
555.
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PERIODONTAL MICROBIOTA AND CAROTID INTIMA-MEDIA THICKNESS: THE ORAL INFECTIONS AND VASCULAR DISEASE EPIDEMIOLOGY STUDY (INVEST), by Desvarieux et al.
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It is now clear that atherosclerosis is a chronic inflammatory
disease induced in large part by traditional cardiovascular
risk factors. Currently, there is great interest in identifying
additional sources of inflammation that might contribute to
the development of atherosclerosis. In this issue, Desvarieux
and colleagues report an association between periodontal infection
and carotid artery atherosclerosis in 657 subjects without known
cardiovascular disease. This association was maintained after
adjusting for traditional risk factors and serum levels of C-reactive
protein. These findings contribute to the growing body of evidence
linking periodontal disease to atherosclerosis. Prospective
studies will be needed to investigate the intriguing possibility
that aggressive periodontal treatment might reduce cardiovascular
risk. See p
576.
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EFFECT OF TAMOXIFEN ON VENOUS THROMBOEMBOLIC EVENTS IN A BREAST CANCER PREVENTION TRIAL, by Decensi et al.
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Tamoxifen use is known to decrease mortality in patients with
estrogen receptor––positive breast cancer. Tamoxifen
use also is associated with increased venous thromboembolism,
but the clinical characteristics of women who are at risk have
been unknown. In this week’s Circulation, Decensi and
colleagues studied 5000 women who were randomly assigned to
treatment with tamoxifen or placebo for 5 years. During this
period, there was a small but statistically significant increase
in venous thromboembolic events in the group of women who took
tamoxifen. Risk factors that were associated with an increased
risk of venous thrombosis while on tamoxifen included age 55
years, increased body mass index, and elevated blood pressure
or cholesterol level. In a subset of almost 700 women with an
elevated risk of coronary disease, a much greater proportion
of those taking tamoxifen developed venous thromboembolic events.
These findings suggest that tamoxifen use may be associated
with venous thrombosis, particularly in women already at risk
for coronary disease. See p
650.
Visit www.circ.ahajournals.org:
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Cardiology Patient Page
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The "Good Cholesterol": High-Density Lipoprotein. See p
e89.
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Images in Cardiovascular Medicine
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Multislice Computed Tomography of Aortic Intramural Hematoma
With Progressive Intercostal Artery Tears: The Chinese Ring-Sword
Sign. See p
e92.
Pitfalls in Coronary Magnetic Resonance Angiography: Right Coronary Artery Occlusion. See p e94.
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Book Review
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Pediatric Hypertension. See p
e97.
Related Articles:
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Impact of Regular Physical Activity on the NAD(P)H Oxidase and Angiotensin Receptor System in Patients With Coronary Artery Disease
- Volker Adams, Axel Linke, Nicolle Kränkel, Sandra Erbs, Stephan Gielen, Sven Möbius-Winkler, Jan F. Gummert, Friedrich Wilhelm Mohr, Gerhard Schuler, and Rainer Hambrecht
Circulation 2005 111: 555-562.
[Abstract]
[Full Text]
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Periodontal Microbiota and Carotid Intima-Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study (INVEST)
- Moïse Desvarieux, Ryan T. Demmer, Tatjana Rundek, Bernadette Boden-Albala, David R. Jacobs, Jr, Ralph L. Sacco, and Panos N. Papapanou
Circulation 2005 111: 576-582.
[Abstract]
[Full Text]
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Effect of Tamoxifen on Venous Thromboembolic Events in a Breast Cancer Prevention Trial
- Andrea Decensi, Patrick Maisonneuve, Nicole Rotmensz, Donato Bettega, Alberto Costa, Virgilio Sacchini, Alessandro Salvioni, Roberto Travaglini, Pasquale Oliviero, Giuseppe D’Aiuto, Marcella Gulisano, Giacomo Gucciardo, Marco Rosselli del Turco, Maria Antonietta Pizzichetta, Serafino Conforti, Bernardo Bonanni, Peter Boyle, Umberto Veronesi for the Italian Tamoxifen Study Group
Circulation 2005 111: 650-656.
[Abstract]
[Full Text]
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The "Good Cholesterol": High-Density Lipoprotein
- Peter P. Toth
Circulation 2005 111: e89-e91.
[Extract]
[Full Text]
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Multislice Computed Tomography of Aortic Intramural Hematoma With Progressive Intercostal Artery Tears: The Chinese Ring-Sword Sign
- Ming-Ting Wu, Tung-Ho Wu, and Doyal Lee
Circulation 2005 111: e92-e93.
[Extract]
[Full Text]
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Pitfalls in Coronary Magnetic Resonance Angiography: Right Coronary Artery Occlusion
- David Maintz, René M. Botnar, Warren J. Manning, and Matthias Stuber
Circulation 2005 111: e94-e96.
[Extract]
[Full Text]
-
Pediatric Hypertension
- Melanie S. Kim
Circulation 2005 111: e97.
[Extract]
[Full Text]
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