Circulation. 2005;112:3667
(Circulation. 2005;112:3667.)
© 2005 American Heart Association, Inc.
Issue Highlights
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INFLUENCE OF EJECTION FRACTION ON CARDIOVASCULAR OUTCOMES IN A BROAD SPECTRUM OF HEART FAILURE PATIENTS, by Solomon et al.
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The degree of left ventricular (LV) dysfunction in patients
with cardiovascular disease is an important determinant of prognosis.
However, data supporting this association have predominantly
been developed from populations with systolic dysfunction below
a certain ejection fraction (EF) cutpoint, and for the most
part from populations not studied with contemporary heart failure
therapy. In this issue of
Circulation, Solomon and colleagues
examine the large Candesartan in Heart Failure Reduction in
Mortality (CHARM) program database to assess the relation of
LV function to outcomes across a broad range of EF (including
heart failure patients with preserved as well as decreased LV
function). The hazard ratio for all-cause mortality increased
by 39% for every 10% reduction in EF below 45%. Risks of many
unfavorable outcomes declined with increasing EF until an EF
of 45%, after which the risks plateaued with continuing increase
in EF within the normal range. These important contemporary
data suggest that EF remains a powerful outcome predictor in
the current era but when above 45% does not incrementally contribute
to risk assessment. See p
3738.
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CARDIAC THREE-DIMENSIONAL MAGNETIC RESONANCE IMAGING AND FLUOROSCOPY MERGING: A NEW APPROACH FOR ELECTROANATOMIC MAPPING TO ASSIST CATHETER ABLATION, by Ector et al.
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Interventional cardiac procedures are critically dependent on
understanding the relation between catheter position and cardiac
anatomy. Electrophysiologists have become skilled at inferring
the location of catheters on the basis of the fluoroscopic image
and electrogram appearance without visualization of the cardiac
anatomy. The limitations of this approach are well recognized
and likely contribute to procedural failures. Nonfluoroscopic
navigation systems are available but expensive. Ector and coworkers
have developed software for integrating magnetic resonance images
of the right atrium into standard biplane fluoroscopy systems.
Detailed anatomic structure can be related to electrophysiological
findings. This technology has the potential to bring the relation
of structure to pathophysiology into better focus with widely
available fluoroscopic systems. See p
3769.
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ENDOTHELIAL FUNCTION IN HEALTHY 11-YEAR-OLD CHILDREN AFTER DIETARY INTERVENTION WITH ONSET IN INFANCY: THE SPECIAL TURKU CORONARY RISK FACTOR INTERVENTION PROJECT FOR CHILDREN (STRIP), by Raitakari et al.
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A heart-healthy diet introduced in early childhood improves
a child’s lipid profile, but its effect on vascular health
is unknown. To investigate whether early introduction of a low–saturated
fat diet has a beneficial effect on endothelial function, Raitakari
and colleagues measured flow-mediated vasodilation in 11-year-old
children participating in a prospective dietary intervention
trial beginning in infancy. Boys in the intervention group had
better endothelial function than those in the control group
(
P=0.0034), but no difference was seen in girls. This effect
was partially explained by diet-induced reduction in serum cholesterol
concentration. Low–saturated fat diet maintained in the
first decade of life is associated with enhanced endothelial
function in boys. See p
3786.
Visit http://www.circ.ahajournals.org:
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Cardiology Patient Page
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Automated External Defibrillators in the Public Domain: Am I
Ready to Use One? See p
e349.
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Images in Cardiovascular Medicine
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Cardiac Failure in the Chick Embryo Resembles Heart Failure
in Humans. See p
e352.
Bedside Diagnosis of Cardiac Rupture by Contrast Echocardiography. See p e354.
Cast of Complex Congenital Heart Malformation in a Living Patient. See p e356.
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Correspondence
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See p
e358.
Related Articles:
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Automated External Defibrillators in the Public Domain: Am I Ready to Use One?
- N.A. Mark Estes, III
Circulation 2005 112: e349-e351.
[Full Text]
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Cardiac Failure in the Chick Embryo Resembles Heart Failure in Humans
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Circulation 2005 112: e352-e353.
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Bedside Diagnosis of Cardiac Rupture by Contrast Echocardiography
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Circulation 2005 112: e354-e355.
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Cast of Complex Congenital Heart Malformation in a Living Patient
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Letter Regarding Article by Mauri et al, "Late Loss in Lumen Diameter and Binary Restenosis for Drug-Eluting Stent Comparison" • Response
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Circulation 2005 112: e358.
[Full Text]
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Influence of Ejection Fraction on Cardiovascular Outcomes in a Broad Spectrum of Heart Failure Patients
- Scott D. Solomon, Nagesh Anavekar, Hicham Skali, John J.V. McMurray, Karl Swedberg, Salim Yusuf, Christopher B. Granger, Eric L. Michelson, Duolao Wang, Stuart Pocock, Marc A. Pfeffer for the Candesartan in Heart Failure Reduction in Mortality (CHARM) Investigators
Circulation 2005 112: 3738-3744.
[Abstract]
[Full Text]
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Cardiac Three-Dimensional Magnetic Resonance Imaging and Fluoroscopy Merging: A New Approach for Electroanatomic Mapping to Assist Catheter Ablation
- Joris Ector, Stijn De Buck, Jef Adams, Steven Dymarkowski, Jan Bogaert, Frederik Maes, and Hein Heidbüchel
Circulation 2005 112: 3769-3776.
[Abstract]
[Full Text]
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Endothelial Function in Healthy 11-Year-Old Children After Dietary Intervention With Onset in Infancy: The Special Turku Coronary Risk Factor Intervention Project for Children (STRIP)
- Olli T. Raitakari, Tapani Rönnemaa, Mikko J. Järvisalo, Tuuli Kaitosaari, Iina Volanen, Katariina Kallio, Hanna Lagström, Eero Jokinen, Harri Niinikoski, Jorma S.A. Viikari, and Olli Simell
Circulation 2005 112: 3786-3794.
[Abstract]
[Full Text]
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INFLUENCE OF EJECTION FRACTION...
CARDIAC THREE-DIMENSIONAL...