Circulation. 2006;113:1921
(Circulation. 2006;113:1921.)
© 2006 American Heart Association, Inc.
Issue Highlights
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NON–TRANSFERRIN-BOUND IRON AND RISK OF CORONARY HEART DISEASE IN POSTMENOPAUSAL WOMEN, by van der A et al.
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The parallel rise in both body iron stores and vascular risk
in women after menopause led to the ‘iron overload‘
theory of coronary heart disease (CHD). Epidemiological studies
relating serum ferritin levels to CHD risk have yielded inconsistent
results, however. In this issue of
Circulation, van der A and
colleagues evaluated a community-based sample of postmenopausal
women to test the hypothesis that a labile iron component associated
with non--transferrin-bound iron (NTBI) might be more suitable
for relating to CHD risk. The investigators noted that women
in the highest NTBI tertile had a statistically significant
53% lower risk of acute myocardial infarction and a nonsignificant
16% lower risk of CHD compared with those in the lowest tertile
in multivariable analyses. Similar results were obtained for
serum iron, transferrin saturation, and serum ferritin. These
observations do not support the presence of an excess risk of
CHD or myocardial infarction in postmenopausal women with relatively
higher levels of NTBI or other measures of iron overload. See
p
1942.
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STEM CELL MOBILIZATION INDUCED BY SUBCUTANEOUS GRANULOCYTE-COLONY STIMULATING FACTOR TO IMPROVE CARDIAC REGENERATION AFTER ACUTE ST-ELEVATION MYOCARDIAL INFARCTION: RESULT OF THE DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STEM CELLS IN MYOCARDIAL INFACTION (STEMMI) TRIAL, by Ripa et al.
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Percutaneous coronary revascularization procedures restore coronary
flow quickly in patients with acute ST-elevation myocardial
infarction, and yet there is often some degree of myocardial
necrosis resulting in left ventricular dysfunction. To prevent
adverse ventricular remodeling, efforts have been devoted to
determining the therapeutic efficacy of bone-marrow–derived
stem cells in preserving ventricular function. These cells have
been isolated ex vivo and infused into the coronary artery or
have been stimulated to exit the bone marrow to home to sites
of myocardial injury by the administration of granulocyte-colony
stimulating factor (G-CSF). Early open-label studies have demonstrated
the safety and potential efficacy of G-CSF. In this issue of
Circulation, Ripa et al present data from the STEM cells in
Myocardial Infarction (STEMMI) Trial. This is the first report
of a randomized, double-blind, placebo-controlled trial of G-CSF
in patients with ST-elevation myocardial infarction and successful
percutaneous revascularization. See p
1983.
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MACROPHAGE METALLOELASTASE ACCELERATES THE PROGRESSION OF ATHEROSCLEROSIS IN TRANSGENIC RABBITS, by Liang et al.
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In this issue of
Circulation, Liang et al used a novel approach
involving the generation of transgenic rabbits to study the
role of the macrophage metalloelastase (matrix metalloproteinase
[MMP]-12) in atherosclerosis. Their results indicate that MMP-12
causes media destruction and pseudoaneurysm formation and accelerates
plaque growth in an animal model that more closely resembles
atherosclerosis in humans. This transgenic rabbit model may
offer new insights into the roles of MMPs in extracellular matrix
remodelling and cellular migration in atherosclerotic lesion
formation that may challenge some prior conclusions based on
mouse models. See p
1993.
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Cardiology Patient Page
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Syncope. See p
e715.
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Images in Cardiovascular Medicine
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Natural Tissue Engineering Inside a Ventricular Septum Defect
Occluder. See p
e718.
Transition From Left Ventricular Hypertrophy to Massive Fibrosis in the Cardiac Variant of Fabry Disease. See p e720.
External Carotid Artery--Internal Jugular Vein Fistula: A Complication of Internal Jugular Cannulation. See p e722.
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Correspondence
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See p
e724.
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Syncope
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Transition From Left Ventricular Hypertrophy to Massive Fibrosis in the Cardiac Variant of Fabry Disease
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External Carotid Artery–Internal Jugular Vein Fistula: A Complication of Internal Jugular Cannulation
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Letter Regarding Article by Ejiri et al, "Possible Role of Brain-Derived Neurotrophic Factor in the Pathogenesis of Coronary Artery Disease"
- Marek Lommatzsch, J. Christian Virchow, Nobutaka Inoue, Junya Ejiri, Seiichi Kobayashi, Rio Shiraki, Kazunori Otsui, Tomoyuki Honjo, Motonori Takahashi, Toshiro Shinke, Junya Shite, Ken-ichi Hirata, Seinosuke Kawashima, Mitsuhiro Yokoyama, Hiroshi Yokozaki, Takao Mori, Yoshitaka Ohashi, Shinobu Ichikawa, Mitsuyasu Terashima, and Kojiro Awano
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Non–Transferrin-Bound Iron and Risk of Coronary Heart Disease in Postmenopausal Women
- Daphne L. van der A, Joannes J.M. Marx, Diederick E. Grobbee, Marjolein H. Kamphuis, Niki A. Georgiou, J. Henny van Kats-Renaud, William Breuer, Z. Ioav Cabantchik, Mark Roest, Hieronymus A.M. Voorbij, and Yvonne T. van der Schouw
Circulation 2006 113: 1942-1949.
[Abstract]
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Stem Cell Mobilization Induced by Subcutaneous Granulocyte-Colony Stimulating Factor to Improve Cardiac Regeneration After Acute ST-Elevation Myocardial Infarction: Result of the Double-Blind, Randomized, Placebo-Controlled Stem Cells in Myocardial Infarction (STEMMI) Trial
- Rasmus Sejersten Ripa, Erik Jørgensen, Yongzhong Wang, Jens Jakob Thune, Jens Christian Nilsson, Lars Søndergaard, Hans Erik Johnsen, Lars Køber, Peer Grande, and Jens Kastrup
Circulation 2006 113: 1983-1992.
[Abstract]
[Full Text]
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NON-TRANSFERRIN-BOUND IRON AND...
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