Circulation. 2006;113:463
(Circulation. 2006;113:463.)
© 2006 American Heart Association, Inc.
Issue Highlights
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GENDER DIFFERENCES IN THE MANAGEMENT AND CLINICAL OUTCOME OF STABLE ANGINA, by Daly et al.
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Many articles have reported differences in the patterns of treatment
of men and women hospitalized for acute coronary syndromes.
Little is known, however, about gender differences in the investigation
and treatment of chronic stable angina. The Euro Heart Survey
of Stable Angina, which enrolled 3779 patients (42% female)
with a clinical diagnosis of stable angina on initial assessment
by a cardiologist, provides an ideal opportunity to study the
effect of gender on clinical decisions in this group. Because
all of the patients had the clinical diagnosis of stable angina,
any differences would not be attributed to diagnostic uncertainty.
The survey collected information on the patients clinical
history, cardiac investigations planned or performed within
a 4-week period of the assessment, and follow-up for clinical
events at 1 year. See p
490.
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PREGNANCY OUTCOMES IN WOMEN WITH CONGENITAL HEART DISEASE, by Khairy et al.
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As survival among patients with congenital heart disease has
improved, estimates of maternal and fetal risk assume increasing
importance. Khairy and colleagues reviewed outcomes of 90 pregnancies
in 53 women with congenital heart disease. Spontaneous abortion
occurred in 12% of pregnancies. One in four women had cardiac
events, most often pulmonary edema (19%). The most common obstetric
event was postpartum hemorrhage, observed in 8% of deliveries.
One in five pregnancies was complicated by preterm delivery.
Four percent of pregnancies ended in intrauterine or neonatal
demise. Patients with subpulmonary ventricular systolic function
and/or severe pulmonary regurgitation and smokers were at the
highest risk of adverse cardiac outcome. Maternal cardiac and
neonatal complication rates are considerable in pregnant women
with congenital heart disease, suggesting the need for careful
surveillance and a multidisciplinary approach. See p
517.
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LOW-MOLECULAR-WEIGHT HEPARIN AS A BRIDGING ANTICOAGULANT EARLY AFTER MECHANICAL HEART VALVE REPLACEMENT, by Meurin et al.
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Treatment of patients with anticoagulation after mechanical
heart valve replacement is important as the risk of thromboembolism
in this setting is high. In this issue of
Circulation, Meurin
and colleagues study patients who underwent valve replacement
and received treatment with the low-molecular-weight heparin
(LMWH) enoxaparin as a bridge until the target international
normalized ratio was reached. The patients (n=250) were followed
up for 90 days during which no valve thrombosis occurred. Although
the data suggest that bridging anticoagulation therapy with
enoxaparin is feasible, this study highlights the importance
of obtaining definitive data with a controlled trial comparing
forms of anticoagulation including LMWH and unfractionated heparin
after mechanical heart valve replacement. See p
564.
Visit http://circ.ahajournals.org:
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Cardiology Patient Page
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On-Pump and Off-Pump Coronary Artery Bypass Grafting. See p
e51.
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Images in Cardiovascular Medicine
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Giant Right Atrium in the Setting of Desmin-Related Restrictive
Cardiomyopathy. See p
e53.
Fetal Cardiac Diverticulum. See p e56.
Multislice Computed Tomography Evaluation 21 Years after Heterotopic Heart Transplantation. See p e57.
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Correspondence
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See p
e59.
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