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Circulation. 2006;113:463

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(Circulation. 2006;113:463.)
© 2006 American Heart Association, Inc.

Issue Highlights


*    GENDER DIFFERENCES IN THE MANAGEMENT AND CLINICAL OUTCOME OF STABLE ANGINA, by Daly et al.
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Many articles have reported differences in the patterns of treatment of men and women hospitalized for acute coronary syndromes. Little is known, however, about gender differences in the investigation and treatment of chronic stable angina. The Euro Heart Survey of Stable Angina, which enrolled 3779 patients (42% female) with a clinical diagnosis of stable angina on initial assessment by a cardiologist, provides an ideal opportunity to study the effect of gender on clinical decisions in this group. Because all of the patients had the clinical diagnosis of stable angina, any differences would not be attributed to diagnostic uncertainty. The survey collected information on the patients’ clinical history, cardiac investigations planned or performed within a 4-week period of the assessment, and follow-up for clinical events at 1 year. See p 490.


*    PREGNANCY OUTCOMES IN WOMEN WITH CONGENITAL HEART DISEASE, by Khairy et al.
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As survival among patients with congenital heart disease has improved, estimates of maternal and fetal risk assume increasing importance. Khairy and colleagues reviewed outcomes of 90 pregnancies in 53 women with congenital heart disease. Spontaneous abortion occurred in 12% of pregnancies. One in four women had cardiac events, most often pulmonary edema (19%). The most common obstetric event was postpartum hemorrhage, observed in 8% of deliveries. One in five pregnancies was complicated by preterm delivery. Four percent of pregnancies ended in intrauterine or neonatal demise. Patients with subpulmonary ventricular systolic function and/or severe pulmonary regurgitation and smokers were at the highest risk of adverse cardiac outcome. Maternal cardiac and neonatal complication rates are considerable in pregnant women with congenital heart disease, suggesting the need for careful surveillance and a multidisciplinary approach. See p 517.


*    LOW-MOLECULAR-WEIGHT HEPARIN AS A BRIDGING ANTICOAGULANT EARLY AFTER MECHANICAL HEART VALVE REPLACEMENT, by Meurin et al.
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Treatment of patients with anticoagulation after mechanical heart valve replacement is important as the risk of thromboembolism in this setting is high. In this issue of Circulation, Meurin and colleagues study patients who underwent valve replacement and received treatment with the low-molecular-weight heparin (LMWH) enoxaparin as a bridge until the target international normalized ratio was reached. The patients (n=250) were followed up for 90 days during which no valve thrombosis occurred. Although the data suggest that bridging anticoagulation therapy with enoxaparin is feasible, this study highlights the importance of obtaining definitive data with a controlled trial comparing forms of anticoagulation including LMWH and unfractionated heparin after mechanical heart valve replacement. See p 564.

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On-Pump and Off-Pump Coronary Artery Bypass Grafting. See p e51.


*    Images in Cardiovascular Medicine
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Giant Right Atrium in the Setting of Desmin-Related Restrictive Cardiomyopathy. See p e53.


Figure 1
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Fetal Cardiac Diverticulum. See p e56.

Multislice Computed Tomography Evaluation 21 Years after Heterotopic Heart Transplantation. See p e57.


*    Correspondence
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See p e59.




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