Circulation. 2006;114:1897
(Circulation. 2006;114:1897.)
© 2006 American Heart Association, Inc.
Issue Highlights
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PRESENCE OF A VENTRICULAR SEPTAL DEFECT AND THE MUSTARD OPERATION ARE RISK FACTORS FOR LATE MORTALITY AFTER THE ATRIAL SWITCH OPERATION: THIRTY YEARS OF FOLLOW-UP IN 417 PATIENTS AT A SINGLE CENTER, by Lange et al.
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Many patients with transposition of the great vessels are surviving
for decades after surgical repair. For decades, the surgical
approach to transposition of the great vessels had been an atrial
switch (Senning or Mustard) procedure. Currently, an arterial
switch is the standard preferred procedure. The late results
of procedures that are not in vogue today, however, are of importance
in caring for the growing population of adults with repaired
congenital cardiac defects. This study by Lange et al, from
a single center, reviews 329 patients after a Senning Procedure
and 88 after a Mustard operation with mean follow-up of 19 years.
This historic collective of the atrial switch operations, especially
those that require ventricular septal defect closure, provides
the clinician with information about how to advise and follow
this patient population. See p
1905.
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PERIPHERAL ARTERIAL DISEASE IN PATIENTS WITH END-STAGE RENAL DISEASE: OBSERVATIONS FROM THE DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY (DOPPS), by Rajagopalan et al.
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Patients with end-stage renal disease and patients with peripheral
arterial disease are both at high risk for cardiovascular morbidity
and mortality. In Rajagopalan and colleagues examined a large
international cohort of hemodialysis patients to understand
the prevalence and prognosis of peripheral arterial disease
in hemodialysis patients. Although they observed significant
international variation, the investigators report a poor prognosis
in the 25% of patients with peripheral arterial disease. Their
research revealed an approximately 40% increased risk of cardiac
and all-cause mortality and a doubling of cardiovascular events
in hemodialysis patients, who already experience significant
risk because of their end-stage kidney disease. The present
study provides support for efforts to understand how to prevent
the progression of chronic kidney disease and the development
of peripheral arterial disease complications. See p
1914.
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INDUCTION OF ORAL TOLERANCE TO OXIDIZED LOW-DENSITY LIPOPROTEIN AMELIORATES ATHEROSCLEROSIS, by van Puijvelde et al.
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and
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SHORT-TERM TREATMENT WITH ANTI-CD3 ANTIBODY REDUCES THE DEVELOPMENT AND PROGRESSION OF ATHEROSCLEROSIS IN MICE, by Steffens et al.
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The notion that atherosclerosis is, in part, an inflammatory
disease is now well established. Moreover, we now have considerable
data concerning both the antigens generated during atherosclerosis
and the cell types involved. The emergence of these data has
prompted speculation that immune modulation may prove to be
an effective strategy to ameliorate atherosclerosis. In this
issue of
Circulation, we have 2 landmark studies that have employed
distinct methods of immune modulation to attenuate atherosclerosis
in animal models. One of these investigations even suggests
the possibility of developing "vaccination" strategies that
could be utilized to prevent human disease. The impact of these
studies is discussed in the accompanying editorial. See pp 1968
and 1977 (editorial on p
1901).
Visit http://circ.ahajournals.org:
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Images in Cardiovascular Medicine
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Percutaneous Transcatheter Balloon Valvuloplasty for Bioprosthetic
Tricuspid Valve Stenosis. See p
e558.
A 21-Year-Old College Student With Chest Distress and ECG Mimicking Dextrocardia. See p e560.
Extensive Invasive Cardiothoracic Aspergillosis. See p e562.
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Book Review
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Obesity and Cardiovascular Disease. See p
e564.
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Correspondence
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See p
e565.
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Immunosuppression in Atherosclerosis: Mobilizing the Opposition Within
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Circulation 2006 114: 1901-1904.
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Percutaneous Transcatheter Balloon Valvuloplasty for Bioprosthetic Tricuspid Valve Stenosis
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A 21-Year-Old College Student With Chest Distress and ECG Mimicking Dextrocardia
- Shi-Sheng Tsou and Pei-Ying Pai
Circulation 2006 114: e560-e561.
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Extensive Invasive Cardiothoracic Aspergillosis
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Letter by Christ et al Regarding Article, "Angiotensin II Potentiates the Slow Component of Delayed Rectifier K+ Current via the AT1 Receptor in Guinea Pig Atrial Myocytes"
- Torsten Christ, Erich Wettwer, and Ursula Ravens
Circulation 2006 114: e565.
[Extract]
[Full Text]
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Presence of a Ventricular Septal Defect and the Mustard Operation Are Risk Factors for Late Mortality After the Atrial Switch Operation: Thirty Years of Follow-Up in 417 Patients at a Single Center
- Rüdiger Lange, Jürgen Hörer, Martin Kostolny, Julie Cleuziou, Manfred Vogt, Raymonde Busch, Klaus Holper, Hans Meisner, John Hess, and Christian Schreiber
Circulation 2006 114: 1905-1913.
[Abstract]
[Full Text]
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Peripheral Arterial Disease in Patients With End-Stage Renal Disease: Observations From the Dialysis Outcomes and Practice Patterns Study (DOPPS)
- Sanjay Rajagopalan, Santo Dellegrottaglie, Anna L. Furniss, Brenda W. Gillespie, Sudtida Satayathum, Norbert Lameire, Akira Saito, Takashi Akiba, Michel Jadoul, Nancy Ginsberg, Marcia Keen, Friedrich K. Port, Debabrata Mukherjee, and Rajiv Saran
Circulation 2006 114: 1914-1922.
[Abstract]
[Full Text]
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PRESENCE OF A VENTRICULAR...
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