(Circulation. 1995;92:1933-1939.)
© 1995 American Heart Association, Inc.
Articles |
From the Cardiology Section, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC; and the Cardiovascular Imaging Center (J.D.T.), Department of Cardiology, the Cleveland Clinic Foundation, Cleveland, Ohio.
Correspondence to William C. Little, MD, Cardiology Section, Bowman Gray School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1045.
| Abstract |
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![]() |
where
=density of blood, L=effective mitral length, and
A=mitral area.
Methods and Results We tested this hypothesis in eight
conscious dogs instrumented for measurement of LV pressure (P) with use
of a micromanometer and volume (V) with use of
sonomicrometers. KLV was determined as the
slope of the late diastolic portion of the LV P-V loop.
KLV was varied from 0.99±0.35 to 2.58±0.92 mm Hg/mL with
use of three graded doses of phenylephrine. We assumed that
=1.0 and that L/A=3.4. Thus, we predicted that
KLV=(0.08/tdec)2 . The LV filling
pattern was determined from the derivative of LV volume (dV/dt).
tdec was measured from peak early filling to the end of
early filling. Predicted KLV and actual KLV
were closely correlated (r=.94, SEE=0.06 mm Hg/mL,
P<.05). The regression line was close to the line of
identity (slope=0.95, intercept=0.13 mm Hg/mL). Dobutamine
did not alter the relation between tdec and
KLV. tdec determined from the mitral valve flow
velocity measured with Doppler echocardiography
correlated well with that measured by dV/dt (r=.89,
P<.01) but was 0.02 seconds longer.
KLV-calculated tdec from the corrected
Doppler tdec provided a good estimate of measured
KLV (r=.75, SEE=0.5 mm Hg/mL,
P<.01).
Conclusions LV chamber stiffness can be determined from the time for deceleration of LV early filling, which can be measured noninvasively.
Key Words: ventricles chamber stiffness
| Introduction |
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Conditions associated with increased LV stiffness are associated with a
more rapid rate of deceleration of early filling and a shorter time for
this deceleration. Based on theoretical analyses, Thomas et
al2 3 and Flachskampf et al4 have predicted
that the rate of early flow deceleration should vary directly with
atrial pressure and mitral valve area and inversely with the combined
stiffness of the left atrium (LA) and LV. We recently observed that
during the time of early filling deceleration, LA pressure is
relatively constant.5 Thus, during this period the
apparent stiffness of the LA is very low. Our previous theoretical
analysis5 predicted that the early filling
deceleration time (tdec) should be proportional to the
inverse square root of LV stiffness or 1/
. Our
observations in conscious dogs during the progressive development of
pacing-induced heart failure were consistent with this
prediction.5 This suggests that the chamber stiffness of
the LV could be calculated from the time for early filling deceleration
(tdec). This has practical clinical importance, since
tdec can be measured noninvasively with the use of
Doppler echocardiography.
Before tdec can be used to measure KLV, several issues remain. First, the proportionality constant between tdec and KLV must be evaluated. Our initial theoretical analysis predicted that
![]() |
However, in this derivation, the numerical constant
(
) depends on the time during flow deceleration that the
integral of dV/dt is evaluated. If KLV is to be calculated
from tdec, the proportionality constant must be
known exactly. In "Appendix 1," we provide a new analysis
that avoids this problem. Second, the ability of tdec to
predict KLV must be evaluated prospectively. Finally,
tdec in our experimental studies is measured from
analysis of the derivative of LV volume (dV/dt). In clinical
studies, tdec is determined with the use of Doppler
mitral valve flow velocity. Thus, tdec measured with the
use of these two techniques must be compared. This study was undertaken
to address these issues in conscious dogs.
| Methods |
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Data Collection
Studies were begun after full recovery from instrumentation (10
days to 2 weeks after surgery). The LV and the LA catheters were
connected to pressure transducers (Sratham p23Db, Gould) calibrated
with a mercury manometer. The signal from the
micromanometer was adjusted to match that of the
catheter. The LA micromanometer was adjusted to
match LA and LV pressures at the end of long periods of diastasis.
The analog signals were recorded on an eight-channel oscillograph (Astro-Med), digitized with an on-line analog-to-digital converter (Data Translation Devices) at 200 Hz, and stored on a floppy disk memory system by use of a 386 computer system. Each data acquisition period lasted for 12 seconds, spanning several respiratory cycles.
Experimental Protocol
Data were recorded with unsedated animals lying quietly in a
sling. Control data were acquired after full recovery from the surgical
instrumentation. In eight animals, LV chamber stiffness
(KLV) was varied with the use of three graded doses of
phenylephrine (approximately 2, 4, and 6 µg/kg per
minute). In a separate group of seven dogs, the effect of increasing
contractility and speeding the rate of relaxation was
assessed by dobutamine infusion (approximately 5 µg/kg
per minute).
Doppler Echocardiography
Immediately after the acquisition of the
micromanometer/ultrasonic crystal data and during
similar heart rates, image-directed, pulsed-wave spectral
Doppler tracings of mitral valve inflow were performed from the LV
apex with the use of a Hewlett-Packard model Sonos 1500 ultrasound
imaging system fitted with a dual-frequency 3.5/2.7-MHz transducer,
an S-VHS video recorder, and an optical digital disk recorder
in six of the animals during phenylephrine infusion. A
small sample volume was placed at the mitral valve leaflet tips, and
the transducer position was adjusted to align the cursor as close to
perpendicular to the mitral valve annulus as possible and to maximize
flow velocity and minimize spectral dispersion. Tracings were made at a
100-mm/s sweep speed, and several multiple-beat, digital cineloops
were recorded for analysis.
Postmortem Evaluation
At the conclusion of the studies, the animals were given an
overdose of pentobarbital and the hearts were examined to confirm the
proper positioning of the instrumentation.
Data Processing and Analysis
The stored digitized data were analyzed by computer
algorithm developed in our laboratory. Hemodynamic
values in each dog were obtained by averaging the data obtained during
the steady-state recording spanning several respiratory
cycles. End diastole was defined as the relative minimum of
LV pressure after the A wave. If this was not clearly apparent, the
peak R wave of the surface ECG was used to indicate end
diastole. End ejection was defined as the time of minimum
dP/dt. The LV volume was calculated as a general ellipsoid using the
equation
VLV=(
/6) · DAP · DSL · DLA,
where DAP, DSL, and
DLA are the anterior-posterior, septal-lateral, and
long-axis dimensions. This method of volume calculation gives a
consistent measure of LV volume (r>.97, SEE<2 mL)
despite changes in LV loading conditions and chamber
configuration.8 9 10 11
Ventricular filling patterns were measured with use of the
time derivative of LV volume (dV/dt).6 7 The
characteristics of these patterns were evaluated by determining the
maximum rates of early diastolic LV filling (peak E) and
atrial filling (peak A). The deceleration time of early
diastolic LV filling (tdec) was defined as the
time interval between maximum rate of early diastolic LV
filling and the zero intercept of the deceleration slope, as previously
described.5 When atrial filling occurred before early
diastolic LV filling decelerated to zero, the slope was
linearly extrapolated to the zero line to obtain tdec. The
deceleration rate of early diastolic LV filling was
calculated as peak E divided by tdec (Fig 1
).
|
The average LV chamber stiffness during diastole was
obtained by dividing the change of the pressure from the time of
minimum LV pressure to end-diastolic pressure
(
PLV) by the change of the volume during this
period.
The time constant of the isovolumic fall in LV pressure was determined by fitting the steady-state data from end ejection to mitral valve opening to the equation P=PAe-t/T+PB, where t is the time from end ejection, T is the exponential time constant of relaxation, and PA and PB are constants determined by the data. The time derivatives of LV pressure and volume were calculated with use of the five-point gaussian technique.12
Analyses of the Doppler tracings were performed off-line by a single observer who was blinded to the results of micromanometer/ultrasonic crystal data analyses. Tracings were reloaded into the Hewlett-Packard Sonos 1500 ultrasound system from the optical-digital disk and analyzed with use of software provided with the system. The three best tracings were analyzed, and the results were averaged. Data were excluded if the mitral flow pattern was not adequately defined to measure tdec. Early diastolic flow deceleration time was measured as the time from the peak early filling velocity to termination of early filling. In tracings in which low velocity filtration of Doppler signals or the onset of late (atrial) filling obscured the termination of early diastolic flow, the flow velocity slope was extrapolated to the baseline.
Time Course of LA Pressure
We evaluated the time course of LA pressure during the time of
early filling deceleration by dividing this period into four
quarters.
Statistical Analysis
Changes in the variables with use of three doses of
phenylephrine and dobutamine were assessed
using repeated-measures ANOVA. If significant differences were
present, paired comparisons between values at control and values
after injection of phenylephrine and dobutamine
were performed with use of the Student-Newman-Keuls test. A probability
level of <.05 was accepted as significant. Values are expressed as
mean±SD.
| Results |
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Prediction of LV Chamber Stiffness (KLV)
A typical example of the LV pressure-volume loops, LV and LA
pressures, and dV/dt recorded during the three graded doses of
phenylephrine is shown in Fig 1
. Measured LV chamber
stiffness progressively increased from 1.03±0.32 at control, reaching
2.62±0.87 mm Hg/mL at the highest dose (P<.05) (Table 1
).
Our theoretical analysis predicts that the time for
deceleration of early filling (tdec) is given by
![]() |
where
=density of blood, L=effective mitral length, and
A=mitral area (see "Appendix 1"). We assumed that
=1.0
g/cm3 and that L/A=3.4. Thus, we predicted that
KLV=(0.08/tdec)2. Predicted
KLV and measured KLV were closely correlated
(r=.94, SEE=0.06, P<.01) (Fig 2
).
The regression line was close to the line of identity
(slope=0.95±0.06, intercept=0.13±0.11 mm Hg/mL).
|
Effect of Dobutamine
Dobutamine increased the heart rate from 108±13 to
121±11 beats per minute (P<.05) and LV
dP/dtmax from 2023±121 to 2645±447 mm Hg/s
(P<.05) and increased the rate of LV relaxation as
indicated by a decrease in the time constant of LV pressure fall from
27.5±3.1 to 24.1±2.1 ms (P<.05) (Table 2
).
Dobutamine did not alter tdec or
KLV. The relation between predicted and measured
KLV was not significantly altered by dobutamine
(Fig 3
).
|
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Measurement by Doppler
tdec measured from dV/dt and by Doppler
determination of mitral flow were well correlated (r=.89,
P<.01) (Fig 4
). The slope of the regression
line was close to unity (1.0±0.1). However, there was an offset of
0.02 seconds. We corrected for this offset and predicted
KLV from the Doppler measured tdec as
|
![]() |
This provided a good estimate of measured KLV (Fig 5
), although there is more scatter than when
tdec is measured from dV/dt.
|
Time Course of LA Pressure
The time course of LA pressure during filling deceleration is
shown in Fig 7
. During all conditions, LA pressure did not
significantly change during the first half of filling deceleration. At
the end of the period, LA pressure increased. During control and the
low dose of phenylephrine, there was no change
three-quarters of the way through the deceleration period. There
was an increase in LA pressure at this time at the two higher doses of
phenylephrine.
|
| Discussion |
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As blood leaves the LA during early diastolic filling its pressure falls, and as LV relaxation and elastic recoil are completed, LV pressure begins to rise with the increase in LV volume.6 13 These effects decrease and then reverse the LA-LV pressure gradient. This decelerates and then stops the initial rapid flow into the ventricle. The magnitude of the fall in LA pressure and rise in LV pressure in early diastole depends both on the volume of the blood leaving the LA and entering the LV and on the stiffness of the LV and LA.2 3 14 However, during the time of early flow deceleration, there is rapid flow into the LA from the pulmonary veins.15 16 Thus, as we have observed previously,5 LA pressure initially remains relatively constant during early flow deceleration; this indicates that LA stiffness should not have an important influence on the deceleration of early filling.
Our theoretical analysis (see "Appendix 1") predicts that the early filling deceleration time should be proportional to the inverse of the square root of LV stiffness or
![]() |
This is analogous to the oscillation time for a
spring, which is proportional to the square root of the spring's
stiffness constant. Furthermore, our analysis predicts that the
proportionality constant between tdec and
1/
is
![]() |
where
is density of blood (
1 g/cm3), L is the
effective length, and A is the effective area of blood moving through
the mitral orifice. We evaluated the proportionality constant as
follows: Flachskampf et al17 showed that L, the effective
length of the mitral flow orifice, is approximately three times the
diameter of the orifice plus the length of the leaflets. Assuming a
canine mitral area of 2 cm2 and leaflet length of 2 cm,
this yields L/A=3.4. Using
=1.0 g/cm3 and 1333
dyne/cm2=1 mm Hg results in
![]() |
In patients with normal mitral functional area of 4 cm2 and mitral length of 3 cm,18 the constant would be similar, 0.07 seconds.
We evaluated this theoretical prediction that KLV can be estimated from tdec by altering LV stiffness by increasing LV afterload with phenylephrine. This increased LV diastolic volume causing the LV to operate on a steeper portion of its curvilinear diastolic P-V relation. Over the range of KLV we studied (1 to 4 mm Hg/mL), tdec measured from LV filling curve (dV/dt) provided an excellent estimate of KLV.
Our theoretical analysis predicts that tdec should
be determined by KLV but not by the rate of LV relaxation,
contractility, or heart rate. Consistent with
this prediction, we found that although dobutamine
increased LV contractility and the rate of LV
relaxation, it did not alter the ability of tdec to predict
KLV (Fig 3
).
We determined LV stiffness from the slope of mid and late diastolic portions of the LV pressure loop, beginning at the time of minimum LV pressure, when LV relaxation is nearing completion. This period spans the time of flow deceleration. Thus, the KLV we determined indicates the functional LV chamber stiffness during the time of flow deceleration and may differ from the passive or end-diastolic stiffness. The LV diastolic pressure-volume relation is exponential in shape, with increasing slope (ie, stiffness) with increasing volume. Thus, the increase in average stiffness (KLV) we measured by infusion of phenylephrine resulted from the increase in LV volume.
Can KLV be calculated from tdec when the
LV stiffness is altered by pathological conditions? We previously
observed that tdec, measured from dV/dt, and
1/
were linearly related as KLV
increased during the development of pacing-induced heart
failure.5 We reanalyzed this data, as shown in
Fig 6
. The predicted and measured KLV are
similar when KLV is varied by phenylephrine or
during the induction of pacing-induced heart failure and not
altered by dobutamine. In each animal, measured and
predicted KLV were linearly related (r=.78±.07,
SEE=0.5±0.2 mL, P<.05 in each animal). This suggests that
KLV can be estimated by tdec during
pathological conditions.
|
We used endocardial diameter gauges to measure LV volume. This technique has been extensively validated in past studies and accurately reflects LV volume under a wide variety of normal and pathological conditions.8 9 10 11 In patients, Doppler measurements of the mitral valve flow velocity are used to assess LV filling patterns. This technique has the advantage that it is noninvasive and can be repeated serially. In this study, we found that tdec measured from the Doppler mitral flow tracing correlated very well with tdec measured from dV/dt. However, tdec from the Doppler flow velocity tracing was on the average about 20 ms longer than tdec measured from dV/dt. This could be due to an underestimation of tdec by the ultrasonically measured dV/dt. However, there are several possible reasons why Doppler might overestimate tdec. First, the measurement of the Doppler signal was made with use of the outside edge of the Doppler envelope, which is the most clearly discernible. Second, Doppler peak filling velocities are not determined solely by LV chamber diastolic properties.5 The Doppler velocity profile at a single point in the inflow tract is influenced both by the LV volume change (dV/dt) and by the propagation of the inflow wave past the sample point. Third, the mitral leaflets come together during flow deceleration. The resulting decrease in mitral valve cross-sectional area would tend to delay the fall in the flow velocity, producing a longer tdec. All of these factors may contribute to the longer tdec determined by Doppler. Finally, obtaining high-quality Doppler recordings of mitral valve velocities is technically more difficult in instrumented dogs than clinically in humans.
The theoretical analysis depends on the simplifying assumption
that LA pressure is relatively constant during flow deceleration. We
observed previously that this is correct during the first three
quarters of the period of filing deceleration.5 However,
by the end of the period of tdec, LA pressure
increases (see Fig 7
). With the higher doses of
phenylephrine, LA pressure was constant only through the
first half of the filling deceleration period. Increases in LA pressure
during filling deceleration would be a source of potential error in the
calculation of KLV from tdec.
"Appendix 2" contains an evaluation of the magnitude of this
error. Under control conditions, the assumption of a constant LA
pressure produced less than a 5% overestimation of KLV.
Under the worst case, during high-dose phenylephrine,
the assumption produced up to a 14% overestimation of
KLV.
Our data suggest that Doppler-derived tdec may have to be corrected by subtracting 0.02 seconds in order to predict KLV. Taking into account the size of the mitral apparatus in patients, this results in the formula for patients
![]() |
The wider scatter in the Doppler-derived data may result partially from the technical difficulty in obtaining Doppler mitral valve recordings in the instrumented animals. Even if this problem were avoided, the estimation of KLV from Doppler tdec would not be accurate enough to detect small changes but should be able to distinguish changes of the order of 1 mm Hg/mL.
Conclusions
Our study demonstrates that early diastolic filling
deceleration time decreases as LV stiffness increases. Our observations
are consistent with a theoretical analysis that
predicts that KLV=(0.08/tdec)2
mm Hg/mL. Furthermore, this study suggests that Doppler
measurement of tdec may be a clinically useful noninvasive
method to evaluate LV chamber stiffness.
| Acknowledgments |
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| Appendix 1 |
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|
|
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![]() | (1) |
The force producing deceleration after peak early flow is the
reverse pressure gradient across the mitral valve
(PLV-PLA) multiplied by the mitral valve area
(A). The mass of blood is determined by density of blood (
) and the
volume of blood in the mitral orifice, which is given by the effective
area (A) multiplied by the effective length (L).14 17
Deceleration is the negative rate of change of flow velocity (-dv/dt).
Flow velocity (v) is equal to the rate of change of LV volume (dV/dt)
divided by the mitral area [(dV/dt)/A]. Therefore
![]() | (2) |
![]() |
Since PLA is approximately constant during flow
deceleration, differentiating Equation 2
produces
![]() | (3) |
The chamber stiffness of the LV is defined as KLV=dPLV/dV. Since v · A=dV/dt, applying the chain rule results in
![]() | (4) |
Combining Equations 3 and 4,
![]() | (5) |
This linear second-order differential equation has a solution of the form y(t)=a · cos(b · t), where d2v/dt2=-a · b2 · cos(bt). If we define t=0 to be at the peak of the E wave, v(0)=E, then
![]() | (6) |
Since v(t) reaches zero at t=
/2, the time for early flow
deceleration (tdec) is given by
![]() | (7) |
Therefore, within the accuracy of the simplifying assumptions,
this analysis predicts that the time for early filling
deceleration should be inversely related to the square root of LV
stiffness. The proportionality constant depends on the viscosity of
blood (
) and an anatomic factor, the ratio of the effective length
to the effective area of the mitral valve apparatus. This
conclusion differs from our previous derivation5 only in
the numerical constant (
/2 versus
).
We evaluate the proportionality constant as follows. Flachskampf et
al17 showed that L, the effective length of the mitral
flow orifice, is approximately three times the diameter of the orifice
plus the length of the leaflets. Assuming a canine mitral area of 2
cm2 and leaflets 2 cm long, this yields L/A=3.4. Using
=1.0 g/cm3 and 1333 dyne/cm2=1 mm Hg
results in
![]() | (8) |
Rearranging results in
![]() | (9) |
| Appendix 2 |
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|
|
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Without assuming that PLA is constant, Equation 3
in
"Appendix 1" becomes
![]() | (10) |
![]() | (11) |
K*LA is the ratio of the change in LA pressure to
the volume that leaves the LA and enters the LV during flow
deceleration. This apparent LA stiffness (K*LA) would be
equivalent to the true LA stiffness if the volume entering the LV was
the same as the change in LA volume. However, during flow deceleration,
there is rapid flow into the LA from the pulmonary veins; thus,
K*LA is not the same as true LA chamber stiffness. Equation 5
becomes
![]() | (12) |
Using similar logic as in "Appendix 1," this results in
![]() | (13) |
To evaluate the error in calculated KLV introduced
by assuming that PLA is constant (and K*LA is
zero), we evaluated the magnitude of K*LA as ratio of the
change in PLA during the period of flow deceleration (from
0 to 0.75 tdec) to the flow out of the LA during this
period (-
dVLV). K*LA is negative (ie, LA
pressure increased despite flow out of the LA). During control, the
absolute value of K*LA was less than 0.06 mm Hg/mL. Thus,
the assumption of a constant PLA caused less than a 5%
overestimation of KLV. In the worst case, during the
high-dose phenylephrine infusion when there was the
largest change in PLA, the absolute value of
K*LA was 0.37 mm Hg/mL, introducing up to a 14%
overestimation of KLV.
Received February 16, 1995; revision received April 10, 1995; accepted April 16, 1995.
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B. Pinamonti, A. Di Lenarda, G. Nucifora, D. Gregori, A. Perkan, and G. Sinagra Incremental prognostic value of restrictive filling pattern in hypertrophic cardiomyopathy: a Doppler echocardiographic study Eur J Echocardiogr, July 1, 2008; 9(4): 466 - 471. [Abstract] [Full Text] [PDF] |
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W. Zhang and S. J. Kovacs The diastatic pressure-volume relationship is not the same as the end-diastolic pressure-volume relationship Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2750 - H2760. [Abstract] [Full Text] [PDF] |
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Meta-Analysis Research Group in Echocardiography ( Independent Prognostic Importance of a Restrictive Left Ventricular Filling Pattern After Myocardial Infarction: An Individual Patient Meta-Analysis: Meta-Analysis Research Group in Echocardiography Acute Myocardial Infarction Circulation, May 20, 2008; 117(20): 2591 - 2598. [Abstract] [Full Text] [PDF] |
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S. Masutani, W. C. Little, H. Hasegawa, H.-J. Cheng, and C.-P. Cheng Restrictive Left Ventricular Filling Pattern Does Not Result From Increased Left Atrial Pressure Alone Circulation, March 25, 2008; 117(12): 1550 - 1554. [Abstract] [Full Text] [PDF] |
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W. A. Jaber, C. S. P. Lam, D. M. Meyer, and M. M. Redfield Revisiting methods for assessing and comparing left ventricular diastolic stiffness: impact of relaxation, external forces, hypertrophy, and comparators Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2738 - H2746. [Abstract] [Full Text] [PDF] |
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L. Hatle How to diagnose diastolic heart failure a consensus statement Eur. Heart J., October 2, 2007; 28(20): 2421 - 2423. [Full Text] [PDF] |
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M. Kasner, D. Westermann, P. Steendijk, R. Gaub, U. Wilkenshoff, K. Weitmann, W. Hoffmann, W. Poller, H.-P. Schultheiss, M. Pauschinger, et al. Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Diastolic Function in Heart Failure With Normal Ejection Fraction: A Comparative Doppler-Conductance Catheterization Study Circulation, August 7, 2007; 116(6): 637 - 647. [Abstract] [Full Text] [PDF] |
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L. Shmuylovich and S. J. Kovacs E-wave deceleration time may not provide an accurate determination of LV chamber stiffness if LV relaxation/viscoelasticity is unknown Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2712 - H2720. [Abstract] [Full Text] [PDF] |
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J. A. Flewitt, T. N. Hobson, J. Wang Jr., C. R. Johnston, N. G. Shrive, I. Belenkie, K. H. Parker, and J. V. Tyberg Wave intensity analysis of left ventricular filling: application of windkessel theory Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2817 - H2823. [Abstract] [Full Text] [PDF] |
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M. M. Riordan and S. J. Kovacs Stiffness- and relaxation-based quantitation of radial left ventricular oscillations: elucidation of regional diastolic function mechanisms J Appl Physiol, May 1, 2007; 102(5): 1862 - 1870. [Abstract] [Full Text] [PDF] |
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Y. Wu and S. J. Kovacs Frequency-based analysis of the early rapid filling pressure-flow relation elucidates diastolic efficiency mechanisms Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2942 - H2949. [Abstract] [Full Text] [PDF] |
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J. D. Thomas and Z. B. Popovic Assessment of Left Ventricular Function by Cardiac Ultrasound J. Am. Coll. Cardiol., November 21, 2006; 48(10): 2012 - 2025. [Abstract] [Full Text] [PDF] |
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C. S. Chung, A. Strunc, R. Oliver, and S. J. Kovacs Diastolic ventricular-vascular stiffness and relaxation relation: elucidation of coupling via pressure phase plane-derived indexes Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2415 - H2423. [Abstract] [Full Text] [PDF] |
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S. Klotz, I. Hay, M. L. Dickstein, G.-H. Yi, J. Wang, M. S. Maurer, D. A. Kass, and D. Burkhoff Single-beat estimation of end-diastolic pressure-volume relationship: a novel method with potential for noninvasive application Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H403 - H412. [Abstract] [Full Text] [PDF] |
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J. K. Oh, L. Hatle, A. J. Tajik, and W. C. Little Diastolic Heart Failure Can Be Diagnosed by Comprehensive Two-Dimensional and Doppler Echocardiography J. Am. Coll. Cardiol., February 7, 2006; 47(3): 500 - 506. [Abstract] [Full Text] [PDF] |
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C. S. Chung, D. M. Ajo, and S. J. Kovacs Isovolumic pressure-to-early rapid filling decay rate relation: model-based derivation and validation via simultaneous catheterization echocardiography J Appl Physiol, February 1, 2006; 100(2): 528 - 534. [Abstract] [Full Text] [PDF] |
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J. O. Hunderi, C. R. Thompson, and O. A. Smiseth Deceleration time of systolic pulmonary venous flow: a new clinical marker of left atrial pressure and compliance J Appl Physiol, February 1, 2006; 100(2): 685 - 689. [Abstract] [Full Text] [PDF] |
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S. Rex, S. Brose, S. Metzelder, L. de Rossi, S. Schroth, R. Autschbach, R. Rossaint, and W. Buhre Normothermic Beating Heart Surgery with Assistance of Miniaturized Bypass Systems: The Effects on Intraoperative Hemodynamics and Inflammatory Response Anesth. Analg., February 1, 2006; 102(2): 352 - 362. [Abstract] [Full Text] [PDF] |
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M. M. Riordan and S. J. Kovacs Quantitation of mitral annular oscillations and longitudinal "ringing" of the left ventricle: a new window into longitudinal diastolic function J Appl Physiol, January 1, 2006; 100(1): 112 - 119. [Abstract] [Full Text] [PDF] |
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W. C. Little Diastolic Dysfunction Beyond Distensibility: Adverse Effects of Ventricular Dilatation Circulation, November 8, 2005; 112(19): 2888 - 2890. [Full Text] [PDF] |
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A. Rovner, N. L. Greenberg, J. D. Thomas, and M. J. Garcia Relationship of diastolic intraventricular pressure gradients and aerobic capacity in patients with diastolic heart failure Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2081 - H2088. [Abstract] [Full Text] [PDF] |
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M. Slama, J. Ahn, M. Peltier, J. Maizel, D. Chemla, J. Varagic, D. Susic, C. Tribouilloy, and E. D. Frohlich Validation of echocardiographic and Doppler indexes of left ventricular relaxation in adult hypertensive and normotensive rats Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1131 - H1136. [Abstract] [Full Text] [PDF] |
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K. Uemura, T. Kawada, A. Kamiya, T. Aiba, I. Hidaka, K. Sunagawa, and M. Sugimachi Prediction of circulatory equilibrium in response to changes in stressed blood volume Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H301 - H307. [Abstract] [Full Text] [PDF] |
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P. A. Grayburn, C. P. Appleton, A. N. DeMaria, B. Greenberg, B. Lowes, J. Oh, J. F. Plehn, P. Rahko, M. St. John Sutton, E. J. Eichhorn, et al. Echocardiographic predictors of morbidity and mortality in patients with advanced heart failure: The Beta-blocker Evaluation of Survival Trial (BEST) J. Am. Coll. Cardiol., April 5, 2005; 45(7): 1064 - 1071. [Abstract] [Full Text] [PDF] |
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H. Tachibana, H.-J. Cheng, T. Ukai, A. Igawa, Z.-S. Zhang, W. C. Little, and C.-P. Cheng Levosimendan improves LV systolic and diastolic performance at rest and during exercise after heart failure Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H914 - H922. [Abstract] [Full Text] [PDF] |
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K. M. Modesto, A. Dispenzieri, S. A. Cauduro, M. Lacy, B. K. Khandheria, P. A. Pellikka, M. Belohlavek, J. B. Seward, R. Kyle, A. J. Tajik, et al. Left atrial myopathy in cardiac amyloidosis: implications of novel echocardiographic techniques Eur. Heart J., January 2, 2005; 26(2): 173 - 179. [Abstract] [Full Text] [PDF] |
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I. H. Styliadis, N. I. Gouzoumas, H. I. Karvounis, C. E. Papadopoulos, G. K. Efthimiadis, M. Karamouzis, G. E. Parharidis, and G. E. Louridas Effects of variation of atrioventricular interval on left ventricular diastolic filling dynamics and atrial natriuretic peptide levels in patients with DDD pacing for complete heart block Europace, January 1, 2005; 7(6): 576 - 583. [Abstract] [Full Text] [PDF] |
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M. Afanasyeva, D. Georgakopoulos, D. Fairweather, P. Caturegli, D. A. Kass, and N. R. Rose Novel Model of Constrictive Pericarditis Associated With Autoimmune Heart Disease in Interferon-{gamma}-Knockout Mice Circulation, November 2, 2004; 110(18): 2910 - 2917. [Abstract] [Full Text] [PDF] |
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S. K. Hamlin, P. S. Villars, J. T. Kanusky, and A. D. Shaw Role of Diastole in Left Ventricular Function, II: Diagnosis and Treatment Am. J. Crit. Care., November 1, 2004; 13(6): 453 - 466. [Abstract] [Full Text] [PDF] |
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A. W. Bowman, P. A. Frihauf, and S. J. Kovacs Time-varying effective mitral valve area: prediction and validation using cardiac MRI and Doppler echocardiography in normal subjects Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1650 - H1657. [Abstract] [Full Text] [PDF] |
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P. Marino, G. Faggian, P. Bertolini, A. Mazzucco, and W. C. Little Early mitral deceleration and left atrial stiffness Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1172 - H1178. [Abstract] [Full Text] [PDF] |
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B. Lopez, R. Querejeta, A. Gonzalez, E. Sanchez, M. Larman, and J. Diez Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure J. Am. Coll. Cardiol., June 2, 2004; 43(11): 2028 - 2035. [Abstract] [Full Text] [PDF] |
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A Rossi, M Cicoira, G Golia, L Zanolla, L Franceschini, P Marino, M Graziani, and P Zardini Amino-terminal propeptide of type III procollagen is associated with restrictive mitral filling pattern in patients with dilated cardiomyopathy: a possible link between diastolic dysfunction and prognosis Heart, June 1, 2004; 90(6): 650 - 654. [Abstract] [Full Text] [PDF] |
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T. Tabata and A. L. Klein Reply J. Am. Coll. Cardiol., March 3, 2004; 43(5): 926 - 926. [Full Text] [PDF] |
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W. C. Little Reply J. Am. Coll. Cardiol., March 3, 2004; 43(5): 928 - 928. [Full Text] [PDF] |
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M. Slama, J. Ahn, J. Varagic, D. Susic, and E. D. Frohlich Long-term left ventricular echocardiographic follow-up of SHR and WKY rats: effects of hypertension and age Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H181 - H185. [Abstract] [Full Text] [PDF] |
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N. H. Andersen, S. H. Poulsen, K. Helleberg, P. Ivarsen, S. T. Knudsen, and C. E. Mogensen Impact of Essential Hypertension and Diabetes Mellitus on Left Ventricular Systolic and Diastolic Performance Eur J Echocardiogr, December 1, 2003; 4(4): 306 - 312. [Abstract] [Full Text] [PDF] |
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A. Rovner, R. Smith, N. L. Greenberg, E. M. Tuzcu, N. Smedira, H. M. Lever, J. D. Thomas, and M. J. Garcia Improvement in diastolic intraventricular pressure gradients in patients with HOCM after ethanol septal reduction Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2492 - H2499. [Abstract] [Full Text] [PDF] |
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I. Loke, I. B. Squire, J. E. Davies, and L. L. Ng Reference ranges for natriuretic peptides for diagnostic use are dependent on age, gender and heart rate Eur J Heart Fail, October 1, 2003; 5(5): 599 - 606. [Abstract] [Full Text] [PDF] |
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N. H Andersen, S. T Knudsen, P. L Poulsen, S. H Poulsen, K. Helleberg, H. Eiskjaer, K. W Hansen, T. Bek, and C. E Mogensen Dual blockade with candesartan cilexetil and lisinopril in hypertensive patients with diabetes mellitus: rationale and design Journal of Renin-Angiotensin-Aldosterone System, June 1, 2003; 4(2): 96 - 99. [Abstract] [PDF] |
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H. Hasegawa, W. C. Little, M. Ohno, S. Brucks, A. Morimoto, H.-J. Cheng, and C.-P. Cheng Diastolic mitral annular velocityduring the development of heart failure J. Am. Coll. Cardiol., May 7, 2003; 41(9): 1590 - 1597. [Abstract] [Full Text] [PDF] |
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J. W.H. Fung, S. K.W. Chan, L. Y.C. Yeung, and J. E. Sanderson Is beta-blockade useful in heart failure patients with atrial fibrillation? An analysis of data from two previously completed prospective trials Eur J Heart Fail, August 1, 2002; 4(4): 489 - 494. [Abstract] [Full Text] [PDF] |
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J. Diez, R. Querejeta, B. Lopez, A. Gonzalez, M. Larman, and J. L. Martinez Ubago Losartan-Dependent Regression of Myocardial Fibrosis Is Associated With Reduction of Left Ventricular Chamber Stiffness in Hypertensive Patients Circulation, May 28, 2002; 105(21): 2512 - 2517. [Abstract] [Full Text] [PDF] |
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E. Lubien, A. DeMaria, P. Krishnaswamy, P. Clopton, J. Koon, R. Kazanegra, N. Gardetto, E. Wanner, and A. S. Maisel Utility of B-Natriuretic Peptide in Detecting Diastolic Dysfunction: Comparison With Doppler Velocity Recordings Circulation, February 5, 2002; 105(5): 595 - 601. [Abstract] [Full Text] [PDF] |
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S. Capomolla, G. Pinna, O. Febo, A. Caporotondi, G. Guazzotti, M. T. La Rovere, M. Gnemmi, A. Mortara, R. Maestri, and F. Cobelli Echo-Doppler mitral flow monitoring: an operative tool to evaluate day-to-day tolerance to and effectiveness of beta-adrenergic blocking agent therapy in patients with chronic heart failure J. Am. Coll. Cardiol., November 15, 2001; 38(6): 1675 - 1684. [Abstract] [Full Text] [PDF] |
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J. B. Lisauskas, J. Singh, A. W. Bowman, and S. J. Kovacs Chamber properties from transmitral flow: prediction of average and passive left ventricular diastolic stiffness J Appl Physiol, July 1, 2001; 91(1): 154 - 162. [Abstract] [Full Text] [PDF] |
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T. D. Kinnaird, C. R. Thompson, and B. I. Munt The deceleration time of pulmonary venous diastolic flow is more accurate than the pulmonary artery occlusion pressure in predicting left atrial pressure J. Am. Coll. Cardiol., June 15, 2001; 37(8): 2025 - 2030. [Abstract] [Full Text] [PDF] |
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P Otasevic, A N Neskovic, Z Popovic, A Vlahovic, D Bojic, M Bojic, and A D Popovic Short early filling deceleration time on day 1 after acute myocardial infarction is associated with short and long term left ventricular remodelling Heart, May 1, 2001; 85(5): 527 - 532. [Abstract] [Full Text] |
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Y. Yong, S. F. Nagueh, S. Shimoni, K. Shan, Z.-X. He, M. J. Reardon, G. V. Letsou, J. F. Howell, M. S. Verani, M. A. Quinones, et al. Deceleration Time in Ischemic Cardiomyopathy : Relation to Echocardiographic and Scintigraphic Indices of Myocardial Viability and Functional Recovery After Revascularization Circulation, March 6, 2001; 103(9): 1232 - 1237. [Abstract] [Full Text] [PDF] |
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S. Nakatani, M. S. Firstenberg, N. L. Greenberg, P. M. Vandervoort, N. G. Smedira, P. M. McCarthy, and J. D. Thomas Mitral inertance in humans: critical factor in Doppler estimation of transvalvular pressure gradients Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1340 - H1345. [Abstract] [Full Text] [PDF] |
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M. J. Garcia, M. S. Firstenberg, N. L. Greenberg, N. Smedira, L. Rodriguez, D. Prior, and J. D. Thomas Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H554 - H561. [Abstract] [Full Text] [PDF] |
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S. K. Gandhi, J. C. Powers, A.-M. Nomeir, K. Fowle, D. W. Kitzman, K. M. Rankin, and W. C. Little The Pathogenesis of Acute Pulmonary Edema Associated with Hypertension N. Engl. J. Med., January 4, 2001; 344(1): 17 - 22. [Abstract] [Full Text] [PDF] |
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M. S. Firstenberg, P. M. Vandervoort, N. L. Greenberg, N. G. Smedira, P. M. McCarthy, M. J. Garcia, and J. D. Thomas Noninvasive estimation of transmitral pressure drop across the normal mitral valve in humans: importance of convective and inertial forces during left ventricular filling J. Am. Coll. Cardiol., November 15, 2000; 36(6): 1942 - 1949. [Abstract] [Full Text] [PDF] |
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J. E. Sanderson, S. K. W. Chan, G. Yip, L. Y. C. Yeung, K. W. Chan, K. Raymond, and K. S. Woo Beta-blockade in heart failure: A comparison of carvedilol with metoprolol J. Am. Coll. Cardiol., November 1, 1999; 34(5): 1522 - 1528. [Abstract] [Full Text] [PDF] |
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A. Yamamuro, K. Yoshida, T. Hozumi, T. Akasaka, T. Takagi, S. Kaji, T. Kawamoto, and J. Yoshikawa Noninvasive evaluation of pulmonary capillary wedge pressure in patients with acute myocardial infarction by deceleration time of pulmonary venous flow velocity in diastole J. Am. Coll. Cardiol., July 1, 1999; 34(1): 90 - 94. [Abstract] [Full Text] [PDF] |
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G. Cerisano, L. Bolognese, N. Carrabba, P. Buonamici, G. M. Santoro, D. Antoniucci, A. Santini, G. Moschi, and P. F. Fazzini Doppler-Derived Mitral Deceleration Time : An Early Strong Predictor of Left Ventricular Remodeling After Reperfused Anterior Acute Myocardial Infarction Circulation, January 19, 1999; 99(2): 230 - 236. [Abstract] [Full Text] [PDF] |
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M. J. Garcia, J. D. Thomas, and A. L. Klein New Doppler echocardiographic applications for the study of diastolic function J. Am. Coll. Cardiol., October 1, 1998; 32(4): 865 - 875. [Abstract] [Full Text] [PDF] |
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S. B. Solomon, S. D. Nikolic, S. A. Glantz, and E. L. Yellin Left ventricular diastolic function of remodeled myocardium in dogs with pacing-induced heart failure Am J Physiol Heart Circ Physiol, March 1, 1998; 274(3): H945 - H954. [Abstract] [Full Text] [PDF] |
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P. P de Tombe Altered contractile function in heart failure Cardiovasc Res, February 1, 1998; 37(2): 367 - 380. [Abstract] [Full Text] [PDF] |
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B. Andersson, K. Caidahl, A. di Lenarda, S. E. Warren, F. Goss, A. Waldenstrom, S. Persson, I. Wallentin, A. Hjalmarson, and F. Waagstein Changes in Early and Late Diastolic Filling Patterns Induced by Long-term Adrenergic ß-Blockade in Patients With Idiopathic Dilated Cardiomyopathy Circulation, August 15, 1996; 94(4): 673 - 682. [Abstract] [Full Text] |
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B. C. Knollmann, S. A. Blatt, K. Horton, F. de Freitas, T. Miller, M. Bell, P. R. Housmans, N. J. Weissman, M. Morad, and J. D. Potter Inotropic Stimulation Induces Cardiac Dysfunction in Transgenic Mice Expressing a Troponin T (I79N) Mutation Linked to Familial Hypertrophic Cardiomyopathy J. Biol. Chem., March 23, 2001; 276(13): 10039 - 10048. [Abstract] [Full Text] [PDF] |
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K. Wachtell, J. N. Bella, J. Rokkedal, V. Palmieri, V. Papademetriou, B. Dahlof, T. Aalto, E. Gerdts, and R. B. Devereux Change in Diastolic Left Ventricular Filling After One Year of Antihypertensive Treatment: The Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study Circulation, March 5, 2002; 105(9): 1071 - 1076. [Abstract] [Full Text] [PDF] |
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