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(Circulation. 1998;97:2302-2306.)
© 1998 American Heart Association, Inc.

Clinical Investigation and Reports

Angiographic Assessment of Myocardial Reperfusion in Patients Treated With Primary Angioplasty for Acute Myocardial Infarction

Myocardial Blush Grade

Arnoud W.J. van `t Hof, MD; Aylee Liem, MD; Harry Suryapranata, MD; Jan C.A. Hoorntje, MD; Menko-Jan de Boer, MD; Felix Zijlstra, MD; ; on behalf of the Zwolle Myocardial Infarction Study Group

From the Department of Cardiology, Hospital De Weezenlanden, Zwolle, the Netherlands.

Correspondence to Dr Felix Zijlstra, Hospital De Weezenlanden, Department of Cardiology, Groot Wezenland 20, 8011 JW Zwolle, The Netherlands.

	Abstract

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Background—The primary objective of reperfusion therapies for acute myocardial infarction is not only restoration of blood flow in the epicardial coronary artery but also complete and sustained reperfusion of the infarcted part of the myocardium.

Methods and Results—We studied 777 patients who underwent primary coronary angioplasty during a 6-year period and investigated the value of angiographic evidence of myocardial reperfusion (myocardial blush grade) in relation to the extent of ST-segment elevation resolution, enzymatic infarct size, left ventricular function, and long-term mortality. The myocardial blush immediately after the angioplasty procedure was graded by two experienced investigators, who were otherwise blinded to all clinical data: 0, no myocardial blush; 1, minimal myocardial blush; 2, moderate myocardial blush; and 3, normal myocardial blush. The myocardial blush was related to the extent of the early ST-segment elevation resolution on the 12-lead ECG. Patients with blush grades 3, 2, and 0/1 had enzymatic infarct sizes of 757, 1143, and 1623 (P<0.0001), respectively, and ejection fractions of 50%, 46%, and 39%, respectively (P<0.0001). After a mean±SD follow-up of 1.9±1.7 years, mortality rates of patients with myocardial blush grades 3, 2, and 0/1 were 3%, 6%, and 23% (P<0.0001), respectively. Multivariate analysis showed that the myocardial blush grade was a predictor of long-term mortality, independent of Killip class, Thrombolysis In Myocardial Infarction grade flow, left ventricular ejection fraction (LVEF), and other clinical variables.

Conclusions—In patients after reperfusion therapy, the myocardial blush grade as seen on the coronary angiogram can be used to describe the effectiveness of myocardial reperfusion and is an independent predictor of long-term mortality.

Key Words: myocardial infarction • angioplasty • angiography

	Introduction

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Over the past decades, great efforts have been made to improve the outcome of patients with acute myocardial infarction.^{1 2 3 4 5 6 7} Many trials have relied on mortality as the end point.^{1 2} The recent data from the Global Utilization of Streptokinase and Tissue Plasminogen activator for Occluded coronary arteries (GUSTO) trial suggest that patency of the epicardial infarct–related coronary artery is an appropriate alternative end point.⁴ However, the primary objective of reperfusion therapies is not only restoration of blood flow in the epicardial coronary artery but also complete and sustained reperfusion of the infarcted myocardium. Echocardiographic assessment of myocardial perfusion after intracoronary injection of sonicated microbubbles is an investigational technique that has been used to describe myocardial reperfusion in patients with restored patency of the infarct-related coronary artery. The so-called "no-reflow" phenomenon, an open epicardial artery without flow into the myocardium, predicts complications and left ventricular dilation.^{8 9} A simple clinical tool that describes the effectiveness of myocardial reperfusion is lacking, because noninvasive means so far have not been applicable in routine clinical practice, and the widely used angiographic parameter, Thrombolysis In Myocardial Infarction (TIMI) flow grade, describes epicardial instead of myocardial blood flow.^{3 4} Therefore, we have introduced an angiographic parameter to describe the effectiveness of myocardial reperfusion: the myocardial blush grade. To validate this new tool, we compared the myocardial blush grades with 12-lead ECG, enzymatic infarct size, left ventricular function, and clinical outcome in a cohort of patients after primary coronary angioplasty and assessed whether this new parameter might give additional prognostic value compared with that of TIMI flow grade.

	Methods

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Patients
From August 1990 until April 1997, 1206 patients fulfilled the criteria for entry into one of our published or ongoing trials.^{6 10 11 12} Two hundred sixty-five patients were treated with thrombolytic therapy. Forty-three patients underwent primary coronary bypass surgery because of severe left main or three-vessel disease, and 62 patients were treated conservatively because of nonsignificant disease and TIMI grade 3 flow of the infarct-related vessel. In 836 patients, primary angioplasty was performed. In 46 patients, the quality of the coronary angiogram did not allow adequate assessment of myocardial blush grade, and for 13 patients, angiographic data were missing. The remaining 777 patients form the basis of this report (Figure 1).

View larger version (19K): [in this window] [in a new window]   Figure 1. Flow chart of patients admitted with acute myocardial infarction and ST-segment elevation between August 1990 and April 1997.

TIMI Flow Grades and Myocardial Blush Grades
TIMI flow grades were assessed as previously described.^{3 10} Both TIMI flow and myocardial blush were graded on the angiograms made immediately after the primary coronary angioplasty procedure by two experienced investigators who were blinded to all data apart from the coronary angiograms. Grading was done on cinefilm at 25 frames/s made in a Philips digital coronary imaging catheterization laboratory. In each patient, the best projection was chosen to assess the myocardial region of the infarct-related coronary artery, preferably without superpositioning of noninfarcted myocardium. Left anterior oblique or left lateral projections were used in 49%, right anterior oblique projections in 23%, both left anterior oblique or left lateral and right anterior oblique projections in 23%, and a cranial view in 5%. Angiographic runs had to be long enough to allow some filling of the venous coronary system, and backflow of the contrast agent into the aorta (Hexabrix, 5 to 15 mL) had to be present to be certain of adequate contrast filling of the epicardial coronary artery. All angiograms were made with 7F or 8F guiding catheters in a standardized fashion after 400 µg nitroglycerin IC had been given immediately after the primary angioplasty procedures, and this procedure allowed quantitative coronary artery analysis.¹⁰ Myocardial blush grades were defined as follows: 0, no myocardial blush or contrast density; 1, minimal myocardial blush or contrast density; 2, moderate myocardial blush or contrast density but less than that obtained during angiography of a contralateral or ipsilateral non–infarct-related coronary artery; and 3, normal myocardial blush or contrast density, comparable with that obtained during angiography of a contralateral or ipsilateral non–infarct-related coronary artery. When myocardial blush persisted ("staining"), this phenomenon suggested leakage of the contrast medium into the extravascular space¹³ and was graded 0. Reproducibility and variabilities of the myocardial blush grades are shown in Table 1.

View this table: [in this window] [in a new window]   Table 1. Reproducibility and Variabilities of Myocardial Blush Grades

ECG
ECGs were done on admission (first ECG) and shortly after arrival in the coronary care unit (second ECG) after the primary coronary angioplasty procedure. The sum of ST-segment elevations was measured 20 ms after the end of the QRS complex in leads I, aVL, and V₁ to V₆ for anterior and leads II, III, aVF, V₅, and V₆ for nonanterior myocardial infarction. The second ECGs were classified with regard to the ST segment in the same way as previously described¹⁴ : 1, normalized, defined as no residual ST-segment elevation; 2, improved, defined as a residual ST-segment elevation <70% of with that on the first ECG; and 3, unchanged, defined as a residual ST-segment elevation >70% of that on the first ECG.

Enzymatic Infarct Size
The methodology for estimation of infarct size is equal to that obtained by the -hydroxybutyrate dehydrogenase method and has been described previously.¹⁵ In brief, infarct size was estimated by measurement of enzyme activities by using lactate dehydrogenase as the reference enzyme. Cumulative enzyme release from five to seven serial measurements up to 72 hours after symptom onset was calculated. A two-compartment model was used, which has been validated in several studies with respect to the turnover of radiolabeled plasma proteins and circulating enzymes.¹⁶

Left Ventricular Function
Before the patients were discharged, left ventricular ejection fraction (LVEF) was measured by radionuclide ventriculography. The multiple-gated equilibrium method was used after in vivo labeling of red blood cells of the patient with [^99mTc]pertechnetate.^{6 17} A General Electric 300 -camera with a low-energy, all-purpose, parallel-hole collimator was used. Global ejection fraction was calculated by a General Electric Star View computer and the fully automated PAGE program. Use of this software program protects against operator bias. The reproducibility of this method is excellent, with a mean difference (±SD) between first and second values of duplicate measurements of 1.2±1.1%.

Mortality
Mortality was assessed in August 1997. Records of patients who visited our outpatient clinic were reviewed. For all other patients, information was obtained from the patients general physician or by direct telephone interview with the patient. For patients who died during follow-up, hospital records and necropsy data were reviewed. No patient was lost to follow-up.

Statistical Analysis
Differences between group means were tested by two-tailed Student's t test. For comparison of rates of discrete outcome variables, a ² test or Fisher's exact test was used. Trend analyses were done as described by Schlesselman.¹⁸ In our presentation of the data, continuous baseline and outcome variables are given as mean±SD, whereas discrete variables are given as absolute values, percentages, or both. In 566 patients in whom TIMI flow as well as myocardial blush grading, enzymatic infarct size, and LVEF were obtained, a multivariate logistic regression analysis was performed to determine independent predictors of long-term mortality. Continuous variables were divided into three categories, with the 25th and 75th percentiles as cutoff points. Odds ratios and 95% confidence intervals were calculated. Survival was represented by Kaplan-Meier curves. A log-rank test was done to assess significant differences in survival between patient subgroups.

	Results

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Myocardial blush grades could be assessed in 777 of the 836 patients (93%). Baseline and angiographic characteristics of the patients classified by myocardial blush grade are shown in Table 2. Myocardial blush grades 0 and 1 were present in 5.8% and 24.6% of patients, respectively. In the presentation of the results, these two groups were combined. Patients with lower blush grades were older and more often presented in Killip class 2 or higher. There was a strong association between infarct location as well as infarct-related artery and myocardial blush grade. Furthermore, patients with higher blush grades had a higher incidence of antegrade flow into the infarct zone before the angioplasty procedure. There is an inverse relation between ischemic time and myocardial blush grade. TIMI flow of the infarct-related vessel could be assessed in all patients. Interpretable ECGs on admission as well as those performed after the primary coronary angioplasty procedure were available for 647 patients (83%). In 2% of the patients, one or both ECGs did not allow an assessment of the ST segments, owing to rhythm or conduction abnormalities. The results of the TIMI flow classification and extent of ST-segment elevation resolution are shown in Table 3. Trend analysis revealed a distinct relation between TIMI flow, ST-segment recovery, and myocardial blush grades. Enzymatic infarct size, LVEF, and long-term mortality at 1.9±1.7 years after the event are shown in Table 4. Enzymatic infarct size could be measured in 659 patients (85%). LVEF measurements were obtained for 584 patients (75%). There was a relation between myocardial blush grade, infarct size, and LVEF: the higher the blush grade, the lower the infarct size and the better the LVEF. During follow-up, 81 patients died (10%). There was also an inverse relation between myocardial blush grades and long-term mortality. In 566 patients, TIMI flow, myocardial blush grade, enzymatic infarct size, and LVEF were known. Multivariate analysis showed that the myocardial blush grade predicted mortality, independent of other well-known variables associated with long-term outcome after myocardial infarction, such as age and Killip class (Table 5). TIMI flow and LVEF were no longer independent predictors of mortality after inclusion of myocardial blush grade into the multivariate model.

View this table: [in this window] [in a new window]   Table 2. Baseline Clinical and Angiographic Characteristics

View this table: [in this window] [in a new window]   Table 3. TIMI Flow and ST Segments on 12-Lead ECG After Primary Coronary Angioplasty

View this table: [in this window] [in a new window]   Table 4. Enzymatic Infarct Size, LVEF, and Mortality

View this table: [in this window] [in a new window]   Table 5. Multivariate Analysis for 566 Patients With Available TIMI Flow, Myocardial Blush Grade, Enzymatic Infarct Size, and LVEF

	Discussion

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The principle finding of our study is that in patients after primary angioplasty for acute infarction, myocardial perfusion, as described by the myocardial blush grade, is reflected by the resolution of ST-segment elevations on the 12-lead ECG; the extent of damage to the infarcted myocardium, as evident from enzymatic infarct size; and radionuclide ventriculography and is independently related to long-term mortality. The myocardial blush grade can therefore be used as a predictor of clinical outcome.

Myocardial Perfusion
We previously described the relation between myocardial flow reserve, assessed by densitometric analyses of contrast-medium passage in the infarcted myocardium, and left ventricular function.¹⁹ However, this semiquantitative method has several pitfalls and limitations and may not be applicable in routine clinical practice.²⁰ Several studies have shown that myocardial perfusion can be assessed visually with intracoronary injection of sonicated microbubbles during echocardiography in the catheterization laboratory. This technique has been used to describe the effectiveness of myocardial reperfusion and predict clinical outcome.^{8 9} Myocardial contrast echocardiography can be used to categorize patients as having reflow or no reflow, and it has been shown that even in the presence of TIMI 3 flow in the epicardial coronary artery, a patient may have no reflow into the myocardium.²¹ Because the venous phase of the coronary angiogram is often clearly visible in patients with no reflow, the echocardiographic or angiographic contrast agent passes from the arterial coronary vessels into the venous system by another route than the myocardial microcirculation in the infarct zone. We developed the angiographic myocardial blush grade based on the visually assessed contrast density in the infarcted myocardium after reperfusion therapy. The angiographic myocardial blush grades are analogous to the TIMI grades for flow in the epicardial infarct–related coronary artery. This information can be obtained during routine high-quality coronary angiography and can be used to describe the effectiveness of reperfusion therapies.

Pathophysiology of the No-Reflow Phenomenon
Coronary occlusion leads to cellular necrosis and myocardial damage. During a short period of occlusion, a variable amount of myocytes may become necrotic while the microvascular network is still intact. If coronary occlusion is prolonged, the microvasculature shows loss of its anatomic integrity.^{9 22} At the time of coronary reopening, myocardial reperfusion is achieved only in areas with anatomically preserved microvasculature, whereas reflow does not occur in myocardium with extensive microvascular damage. The no-reflow phenomenon is therefore associated with relatively more extensive necrosis and, as a consequence, is a predictor of poor regional and global contractile function.^{8 9} Contrariwise, adequate myocardial reflow shortly after epicardial coronary reperfusion is an accurate indication of microvascular integrity and consequently, of regional and overall functional recovery in patients with acute myocardial infarction.^{9 19}

Comparison of Myocardial Blush Grades With TIMI Flow Grades
Myocardial blush grade was related to TIMI flow. However, from Table 3, it is clear that the majority of patients with myocardial blush grade 2 had "normal" TIMI flow. The patients with TIMI 3 flow but low blush grades can be regarded as having no reflow in a comparable way as patients who lack myocardial contrast on their echocardiogram after intracoronary injection of sonicated microbubbles.^{8 9} A recent study from our group showed that a substantial number of patients with TIMI 3 flow have persistent ST-segment elevation on the postangioplasty ECG, suggesting impairment of myocardial reperfusion.¹⁴ A further differentiation among patients with TIMI 3 flow is, therefore, needed and of clinical relevance. Multivariate logistic regression analyses showed that the myocardial blush grade was related to long-term mortality independent of TIMI flow. Therefore, an angiographic variable that takes the extent of myocardial reperfusion into account is of additional prognostic value. Figure 2 shows Kaplan-Meier curves and log-rank analysis for TIMI and myocardial blush grade, and it illustrates that survival in patients with TIMI 3 flow is not as high as survival in patients who have a high blush grade of the myocardium after primary angioplasty. Furthermore, it shows that myocardial blush grading might identify a much larger population at risk for adverse outcomes: n=236 (30%) with blush grades 0 to 1 versus n=87 (11%) with TIMI flow 0 to 2.

View larger version (24K): [in this window] [in a new window]   Figure 2. Kaplan-Meier survival curves for 777 patients with known TIMI flow and myocardial blush grades. Myocardial blush grade 0 or 1 indicates no or minimal blush or contrast density of myocardium supplied by infarct-related vessel on postangioplasty angiogram. Blush grade 2 indicates moderate blush or contrast density, and blush grade 3 indicates normal blush or contrast density, comparable with blush obtained during angiography of contralateral or ipsilateral non–infarct-related coronary artery. TIMI flow is defined as previously described.3 Cum. Survival indicates cumulative survival.

Limitations
The interobserver and intraobserver variabilities associated with subjective angiographic assessments are certainly a limitation of the myocardial blush grades and are comparable with the variabilities in TIMI flow grades for epicardial coronary blood flow.^{3 23}

Implications
Early and sustained restoration of flow into the infarcted myocardium is the aim of reperfusion therapies for acute myocardial infarction. Angiographic studies of reperfusion therapies should assess myocardial perfusion as well as flow in the epicardial infarct–related coronary artery. A new standard for success of reperfusion therapy has been proposed: "90% TIMI 3 flow at 90 minutes."²⁴ We think that the future standard should include the phrase, "with evidence of adequate myocardial reperfusion."

Received December 3, 1997; revision received January 20, 1998; accepted February 4, 1998.

	References

Top Abstract Introduction Methods Results Discussion References

 
1. Fibrinolytic Therapy Trialists' (FTT) collaborative group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet. 1994;343:311–322.[Medline] [Order article via Infotrieve]

2. Granger CB, Califf RM, Topol EJ. Thrombolytic therapy for acute myocardial infarction: a review. Drugs. 1992;44:293–325.[Medline] [Order article via Infotrieve]

3. Chesebro JH, Knatterud G, Roberts R, Borer J, Cohen LS, Dalen J, Dodge HT, Francis CK, Hillis D, Ludbrook P, Markis JE, Mueller H, Passamani ER, Powers ER, Rao AK, Robertson T, Ross A, Ryan TJ, Sobel BE, Willerson J, Williams DO, Zaret BL, Braunwald E. Thrombolysis in myocardial infarction (TIMI) trial, phase 1: a comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Circulation. 1987;76:142–154.[Abstract/Free Full Text]

4. The GUSTO Angiographic Investigators. The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival, after acute myocardial infarction. N Engl J Med. 1993;329:1615–1622.[Abstract/Free Full Text]

5. Grines CL, Browne KF, Marco J, Rothbaum D, Stone GW, O'Keefe J, Overlie P, Donohue B, Chelliah N, Timmis GC, Vlietstra RE, Stezelecki M, Puchrowicz-Ochoki S, O'Neill WW, for the Primary Angioplasty in Myocardial Infarction Study group. A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. N Engl J Med. 1993;328:673–679.[Abstract/Free Full Text]

6. Zijlstra F, de Boer MJ, Hoorntje JCA, Reiffers S, Reiber JHC, Suryapranata H. A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction. N Engl J Med. 1993;328:680–684.[Abstract/Free Full Text]

7. Gibbons RJ, Holmes DR, Reeder GS, Bayley KR, Hopfenspirger MR, Gersh BJ. Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. N Engl J Med. 1993;328:685–691.[Abstract/Free Full Text]

8. Ito H, Maruyama A, Iwakura K, Takiuchi S, Masuyama T, Hori M, Higashino Y, Fujii K, Minamino T. Clinical implications of the "no reflow" phenomenon. Circulation. 1996;93:223–228.[Abstract/Free Full Text]

9. Iliceto S, Marangelli V, Marchese A, Amico A, Galiuto L, Rizzon P. Myocardial contrast echocardiography in acute myocardial infarction: pathophysiological background and clinical applications. Eur Heart J. 1996;17:344–353.[Abstract/Free Full Text]

10. de Boer MJ, Reiber JHC, Suryapranata H, van den Brand MJBM, Hoorntje JCA, Zijlstra F. Angiographic findings and catheterisation laboratory events in patients with primary coronary angioplasty or streptokinase therapy for acute myocardial infarction. Eur Heart J. 1995;16:1347–1356.[Abstract/Free Full Text]

11. Zijlstra F, Beukema WP, van `t Hof AWJ, Liem AL, Reiffers S, Hoorntje JCA, Suryapranata H, de Boer MJ. Randomized comparison of primary coronary angioplasty with thrombolytic therapy in low risk patients with acute myocardial infarction. J Am Coll Cardiol.. 1997;29:908–912.

12. Suryapranata H, van `t Hof AWJ, Hoorntje JCA, de Boer MJ, Zijlstra F. Randomized comparison of coronary stenting with balloon angioplasty in patients with acute myocardial infarction. Circulation. 1998. In press.

13. Little WC, Rogers EW. Angiographic evidence of hemorrhagic myocardial infarction after intracoronary thrombolysis with streptokinase. Am J Cardiol. 1983;51:906–908.[Medline] [Order article via Infotrieve]

14. van `t Hof AWJ, Liem AL, de Boer MJ, Zijlstra F, for the Zwolle Myocardial Infarction Study Group. Clinical value of 12-lead electrocardiogram after successful reperfusion therapy for acute myocardial infarction. Lancet. 1997;350:615–619.[Medline] [Order article via Infotrieve]

15. van der Laarse A, Hermens WT, Hollaar L, Jol M, Willems GM, Lemmers HEAS, Liem AH, Souverijn JHM, Oudhof JH, De Hooge J, Buis B, Arntzenius AC. Assessment of myocardial damage in patients with acute myocardial infarction by serial measurement of serum -hydroxybutyrate dehydrogenase levels. Am Heart J. 1984;107:248–260.[Medline] [Order article via Infotrieve]

16. Hermens WT, Willems GM, Nijssen KM, Simoons ML. Effect of thrombolytic treatment delay on myocardial infarct size. Lancet. 1992;340:1297. Letter.[Medline] [Order article via Infotrieve]

17. Zijlstra F, de Boer MJ, Beukema WP, Liem AL, Reiffers S, Huysmans D, Hoorntje JCA, Suryapranata H, Simoons ML. Mortality, reinfarction, left ventricular ejection fraction and costs following reperfusion therapies for acute myocardial infarction. Eur Heart J. 1996;17:382–387.[Abstract/Free Full Text]

18. Schlesselman JJ. Case-Control Studies. New York, NY: Oxford Press, 1982:203–206.

19. Suryapranata H, Zijlstra F, MacLeod DC, van den Brand M, de Feyter PJ, Serruys PW. Predictive value of reactive hyperemic response on reperfusion on recovery of regional myocardial function after coronary angioplasty in acute myocardial infarction. Circulation. 1994;89:1109–1117.[Abstract/Free Full Text]

20. Zijlstra F, Widimsky P, Suryapranata H. Possibilities and limitations of myocardial flow reserve. In: Reiber JHC, Serruys PW, eds. Progress in Quantitative Coronary Arteriography. Dordrecht, Netherlands: Kluwer Academics Publishers; 1994:141–159.

21. Ito H, Okamura A, Iwakura K, Masuyama T, Hori M, Takiuchi S, Negoro S, Nakatsuchi Y, Taniyama Y, Higashino Y, Fujii K, Minamino T. Myocardial perfusion patterns related to thrombolysis in myocardial infarction perfusion grades after coronary angioplasty in patients with acute anterior wall myocardial infarction. Circulation. 1996;93:1993–1999.[Abstract/Free Full Text]

22. Kloner RA, Ganote CE, Jennings RB. The "no reflow" phenomenon after temporary coronary occlusion in the dog. J Clin Invest. 1974;54:1496–1508.

23. Gibson CM, Cannon CP, Daley WL, Dodge JT, Alexander B, Marble SJ, McCabe CH, Raymond L, Fortin T, Poole K, Braunwald E. TIMI frame count: A quantitative method of assessing coronary artery flow. Circulation. 1996;93:879–888.[Abstract/Free Full Text]

24. Forrester JS. New standard for success of thrombolytic therapy: an earnest proposal. Circulation. 1995;92:2026–2028.[Free Full Text]

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				Authors/Task Force Members, F. Van de Werf, J. Bax, A. Betriu, C. Blomstrom-Lundqvist, F. Crea, V. Falk, G. Filippatos, K. Fox, K. Huber, et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: The Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology: Eur. Heart J., December 1, 2008; 29(23): 2909 - 2945. [Full Text] [PDF]

				J. Saw, C. Densem, S. Walsh, P. Jokhi, A. Starovoytov, R. Fox, G. Wong, C. Buller, D. Ricci, G.B. J. Mancini, et al. The Effects of Aspirin and Clopidogrel Response on Myonecrosis After Percutaneous Coronary Intervention: A BRIEF-PCI (Brief Infusion of Intravenous Eptifibatide Following Successful Percutaneous Coronary Intervention) Trial Substudy J. Am. Coll. Cardiol. Intv., December 1, 2008; 1(6): 654 - 659. [Abstract] [Full Text] [PDF]

				G De Luca, C M Gibson, F Bellandi, S Murphy, M Maioli, M Noc, U Zeymer, D Dudek, H-R Arntz, S Zorman, et al. Early glycoprotein IIb-IIIa inhibitors in primary angioplasty (EGYPT) cooperation: an individual patient data meta-analysis Heart, December 1, 2008; 94(12): 1548 - 1558. [Abstract] [Full Text] [PDF]

				G. De Luca Adjunctive antithrombotic therapy during primary percutaneous coronary intervention Eur. Heart J. Suppl., December 1, 2008; 10(suppl_J): J2 - J14. [Abstract] [Full Text] [PDF]

				Y.L. Gu, M.L. Fokkema, and F. Zijlstra The Emerging Role of Thrombus Aspiration in the Management of Acute Myocardial Infarction Circulation, October 28, 2008; 118(18): 1780 - 1782. [Full Text] [PDF]

				M. Albertal, F. Cura, A. G. Escudero, L. T. Padilla, J. Thierer, M. Trivi, J. A Belardi, and PREMIAR InvestigatorsBelardi Relationship Between Collateral Circulation and Successful Myocardial Reperfusion in Acute Myocardial Infarction: A Subanalysis of the PREMIAR Trial Angiology, October 1, 2008; 59(5): 587 - 592. [Abstract] [PDF]

				C. E. Buller, Y. Fu, K. W. Mahaffey, T. G. Todaro, P. Adams, C. M. Westerhout, H. D. White, A. W.J. van 't Hof, F. J. Van de Werf, G. S. Wagner, et al. ST-Segment Recovery and Outcome After Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction: Insights From the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) Trial Circulation, September 23, 2008; 118(13): 1335 - 1346. [Abstract] [Full Text] [PDF]

				A. Abbate, M. C. Kontos, and G. G.L. Biondi-Zoccai No-reflow: the next challenge in treatment of ST-elevation acute myocardial infarction Eur. Heart J., August 1, 2008; 29(15): 1795 - 1797. [Full Text] [PDF]

				G. Niccoli, S. Giubilato, E. Russo, C. Spaziani, A. Leo, I. Porto, A. M. Leone, F. Burzotta, S. Riondino, F. Pulcinelli, et al. Plasma levels of thromboxane A2 on admission are associated with no-reflow after primary percutaneous coronary intervention Eur. Heart J., August 1, 2008; 29(15): 1843 - 1850. [Abstract] [Full Text] [PDF]

				Y. Ikari, M. Sakurada, K. Kozuma, S. Kawano, T. Katsuki, K. Kimura, T. Suzuki, T. Yamashita, A. Takizawa, K. Misumi, et al. Upfront Thrombus Aspiration in Primary Coronary Intervention for Patients With ST-Segment Elevation Acute Myocardial Infarction: Report of the VAMPIRE (VAcuuM asPIration thrombus REmoval) Trial J. Am. Coll. Cardiol. Intv., August 1, 2008; 1(4): 424 - 431. [Abstract] [Full Text] [PDF]

				R. Nijveldt, A. M. Beek, A. Hirsch, M. G. Stoel, M. B.M. Hofman, V. A.W.M. Umans, P. R. Algra, J. W.R. Twisk, and A. C. van Rossum Functional recovery after acute myocardial infarction comparison between angiography, electrocardiography, and cardiovascular magnetic resonance measures of microvascular injury. J. Am. Coll. Cardiol., July 15, 2008; 52(3): 181 - 189. [Abstract] [Full Text] [PDF]

				T. Chechi, S. Vecchio, G. Vittori, G. Giuliani, A. Lilli, G. Spaziani, L. Consoli, G. Baldereschi, G. G.L. Biondi-Zoccai, I. Sheiban, et al. ST-segment elevation myocardial infarction due to early and late stent thrombosis a new group of high-risk patients. J. Am. Coll. Cardiol., June 24, 2008; 51(25): 2396 - 2402. [Abstract] [Full Text] [PDF]

				P. J. Vlaar, T. Svilaas, M. Vogelzang, G. F. Diercks, B. J. de Smet, A. F. van den Heuvel, R. L. Anthonio, G. A. Jessurun, E. Tan, A. J. Suurmeijer, et al. A Comparison of 2 Thrombus Aspiration Devices With Histopathological Analysis of Retrieved Material in Patients Presenting With ST-Segment Elevation Myocardial Infarction J. Am. Coll. Cardiol. Intv., June 1, 2008; 1(3): 258 - 264. [Abstract] [Full Text] [PDF]

				A. Okamura, H. Ito, K. Iwakura, T. Kurotobi, Y. Koyama, M. Date, Y. Higuchi, K. Inoue, and K. Fujii Clinical Implications of Distal Embolization During Coronary Interventional Procedures in Patients With Acute Myocardial Infarction: Quantitative Study With Doppler Guidewire J. Am. Coll. Cardiol. Intv., June 1, 2008; 1(3): 268 - 276. [Abstract] [Full Text] [PDF]

				E. Mahmud, T. W.R. Smith, V. Palakodeti, O. Zaidi, L. Ang, C. R. Mitchell, N. Zafar, G. Bromberg-Marin, S. Keramati, and S. Tsimikas Renal Frame Count and Renal Blush Grade: Quantitative Measures That Predict the Success of Renal Stenting in Hypertensive Patients With Renal Artery Stenosis J. Am. Coll. Cardiol. Intv., June 1, 2008; 1(3): 286 - 292. [Abstract] [Full Text] [PDF]

				S. J. Brener, D. J. Moliterno, P. E. Aylward, A. W.J. van't Hof, W. Ruzyllo, W. W. O'Neill, C. W. Hamm, C. M. Westerhout, C. B. Granger, P. W. Armstrong, et al. Reperfusion after primary angioplasty for ST-elevation myocardial infarction: predictors of success and relationship to clinical outcomes in the APEX-AMI Angiographic Study Eur. Heart J., May 1, 2008; 29(9): 1127 - 1135. [Abstract] [Full Text] [PDF]

				R. Kawaguchi Reply J. Am. Coll. Cardiol., April 1, 2008; 51(13): 1324 - 1325. [Full Text] [PDF]

				M. A. McDonald, Y. Fu, U. Zeymer, G. Wagner, S. G. Goodman, A. Ross, C. B. Granger, F. Van de Werf, P. W. Armstrong, and for the ASSENT-4 PCI Investigators Adverse outcomes in fibrinolytic-based facilitated percutaneous coronary intervention: insights from the ASSENT-4 PCI electrocardiographic substudy Eur. Heart J., April 1, 2008; 29(7): 871 - 879. [Abstract] [Full Text] [PDF]

				A. O. Spiel, J. C. Gilbert, and B. Jilma Von Willebrand Factor in Cardiovascular Disease: Focus on Acute Coronary Syndromes Circulation, March 18, 2008; 117(11): 1449 - 1459. [Abstract] [Full Text] [PDF]

				T. Svilaas, P. J. Vlaar, I. C. van der Horst, G. F.H. Diercks, B. J.G.L. de Smet, A. F.M. van den Heuvel, R. L. Anthonio, G. A. Jessurun, E.-S. Tan, A. J.H. Suurmeijer, et al. Thrombus Aspiration during Primary Percutaneous Coronary Intervention N. Engl. J. Med., February 7, 2008; 358(6): 557 - 567. [Abstract] [Full Text] [PDF]

				L. Galiuto, B. Garramone, A. Scara, A. G. Rebuzzi, F. Crea, G. La Torre, S. Funaro, M. Madonna, F. Fedele, L. Agati, et al. The extent of microvascular damage during myocardial contrast echocardiography is superior to other known indexes of post-infarct reperfusion in predicting left ventricular remodeling: results of the multicenter AMICI study. J. Am. Coll. Cardiol., February 5, 2008; 51(5): 552 - 559. [Abstract] [Full Text] [PDF]

				A. Sato, M. Hiroe, T. Nozato, H. Hikita, Y. Ito, H. Ohigashi, M. Tamura, A. Takahashi, M. Isobe, and K. Aonuma Early validation study of 64-slice multidetector computed tomography for the assessment of myocardial viability and the prediction of left ventricular remodelling after acute myocardial infarction Eur. Heart J., February 2, 2008; 29(4): 490 - 498. [Abstract] [Full Text] [PDF]

				G De Luca, H Suryapranata, J P Ottervanger, J C A Hoorntje, A T M Gosselink, J-H Dambrink, M-J de Boer, and A W J v. Hof Postprocedural single-lead ST-segment deviation and long-term mortality in patients with ST-segment elevation myocardial infarction treated by primary angioplasty Heart, January 1, 2008; 94(1): 44 - 47. [Abstract] [Full Text] [PDF]

				E. Seyfeli, A. Abaci, M. Kula, R. Topsakal, N. K. Eryol, H. Arinc, I. Ozdogru, and A. Ergin Myocardial Blush Grade: To Evaluate Myocardial Viability in Patients With Acute Myocardial Infarction Angiology, November 1, 2007; 58(5): 556 - 560. [Abstract] [PDF]

				K. M. Marques, P. Knaapen, R. Boellaard, N. Westerhof, A. A. Lammertsma, C. A. Visser, and F. C. Visser Hyperaemic microvascular resistance is not increased in viable myocardium after chronic myocardial infarction Eur. Heart J., October 1, 2007; 28(19): 2320 - 2325. [Abstract] [Full Text] [PDF]

				I. Kusama, K. Hibi, M. Kosuge, N. Nozawa, H. Ozaki, H. Yano, S. Sumita, K. Tsukahara, J. Okuda, T. Ebina, et al. Impact of Plaque Rupture on Infarct Size in ST-Segment Elevation Anterior Acute Myocardial Infarction J. Am. Coll. Cardiol., September 25, 2007; 50(13): 1230 - 1237. [Abstract] [Full Text] [PDF]

				V. Kurowski, A. Kaiser, K. von Hof, D. P. Killermann, B. Mayer, F. Hartmann, H. Schunkert, and P. W. Radke Apical and Midventricular Transient Left Ventricular Dysfunction Syndrome (Tako-Tsubo Cardiomyopathy)* Frequency, Mechanisms, and Prognosis Chest, September 1, 2007; 132(3): 809 - 816. [Abstract] [Full Text] [PDF]

				X. Liu, Y. Huang, P. Pokreisz, P. Vermeersch, G. Marsboom, M. Swinnen, E. Verbeken, J. Santos, M. Pellens, H. Gillijns, et al. Nitric Oxide Inhalation Improves Microvascular Flow and Decreases Infarction Size After Myocardial Ischemia and Reperfusion J. Am. Coll. Cardiol., August 21, 2007; 50(8): 808 - 817. [Abstract] [Full Text] [PDF]

				G. Sianos, M. I. Papafaklis, J. Daemen, S. Vaina, C. A. van Mieghem, R. T. van Domburg, L. K. Michalis, and P. W. Serruys Angiographic Stent Thrombosis After Routine Use of Drug-Eluting Stents in ST-Segment Elevation Myocardial Infarction: The Importance of Thrombus Burden J. Am. Coll. Cardiol., August 14, 2007; 50(7): 573 - 583. [Abstract] [Full Text] [PDF]

				M. Sezer, H. Oflaz, T. Goren, I. Okcular, B. Umman, Y. Nisanci, A. K. Bilge, Y. Sanli, M. Meric, and S. Umman Intracoronary Streptokinase after Primary Percutaneous Coronary Intervention N. Engl. J. Med., May 3, 2007; 356(18): 1823 - 1834. [Abstract] [Full Text] [PDF]

				M. Napodano, A. Ramondo, and S. Iliceto Adjunctive Thrombectomy in Acute Myocardial Infarction: For Some but Not for All J. Am. Coll. Cardiol., April 10, 2007; 49(14): 1586 - 1586. [Full Text] [PDF]

				M. Maioli, F. Bellandi, M. Leoncini, A. Toso, and R. P. Dabizzi Randomized Early Versus Late Abciximab in Acute Myocardial Infarction Treated With Primary Coronary Intervention (RELAx-AMI Trial) J. Am. Coll. Cardiol., April 10, 2007; 49(14): 1517 - 1524. [Abstract] [Full Text] [PDF]

				P. Silva-Orrego, P. Colombo, and R. Bigi Reply J. Am. Coll. Cardiol., April 10, 2007; 49(14): 1586 - 1587. [Full Text] [PDF]

				F. Fernandez-Aviles, J. J. Alonso, G. Pena, J. Blanco, J. Alonso-Briales, J. Lopez-Mesa, F. Fernandez-Vazquez, J. Moreu, R. A. Hernandez, A. Castro-Beiras, et al. Primary angioplasty vs. early routine post-fibrinolysis angioplasty for acute myocardial infarction with ST-segment elevation: the GRACIA-2 non-inferiority, randomized, controlled trial Eur. Heart J., April 2, 2007; 28(8): 949 - 960. [Abstract] [Full Text] [PDF]

				G. Campo, M. Valgimigli, D. Gemmati, G. Percoco, S. Tognazzo, G. Cicchitelli, L. Catozzi, P. Malagutti, M. Anselmi, C. Vassanelli, et al. Value of Platelet Reactivity in Predicting Response to Treatment and Clinical Outcome in Patients Undergoing Primary Coronary Intervention: Insights Into the STRATEGY Study J. Am. Coll. Cardiol., November 9, 2006; (2006) j.jacc.2005.12.085v1. [Abstract] [Full Text] [PDF]

				M. Mariani, R. Fetiveau, E. Rossetti, A. Poli, F. Poletti, P. Vandoni, M. D'Urbano, F. Cafiero, G. Mariani, C. Klersy, et al. Significance of total and differential leucocyte count in patients with acute myocardial infarction treated with primary coronary angioplasty Eur. Heart J., November 1, 2006; 27(21): 2511 - 2515. [Abstract] [Full Text] [PDF]

				P. Silva-Orrego, P. Colombo, R. Bigi, D. Gregori, A. Delgado, P. Salvade, J. Oreglia, P. Orrico, A. de Biase, G. Piccalo, et al. Thrombus Aspiration Before Primary Angioplasty Improves Myocardial Reperfusion in Acute Myocardial Infarction: The DEAR-MI (Dethrombosis to Enhance Acute Reperfusion in Myocardial Infarction) Study J. Am. Coll. Cardiol., October 17, 2006; 48(8): 1552 - 1559. [Abstract] [Full Text] [PDF]

				K Vijayalakshmi, V J Whittaker, B Kunadian, J Graham, R A Wright, J A Hall, A Sutton, and M A de Belder Prospective, randomised, controlled trial to study the effect of intracoronary injection of verapamil and adenosine on coronary blood flow during percutaneous coronary intervention in patients with acute coronary syndromes Heart, September 1, 2006; 92(9): 1278 - 1284. [Abstract] [Full Text] [PDF]

				G. Niccoli, G. A. Lanza, S. Shaw, E. Romagnoli, D. Gioia, F. Burzotta, C. Trani, M. A. Mazzari, R. Mongiardo, M. De Vita, et al. Endothelin-1 and acute myocardial infarction: a no-reflow mediator after successful percutaneous myocardial revascularization Eur. Heart J., August 1, 2006; 27(15): 1793 - 1798. [Abstract] [Full Text] [PDF]

				A. Ali, D. Cox, N. Dib, B. Brodie, D. Berman, N. Gupta, K. Browne, R. Iwaoka, M. Azrin, D. Stapleton, et al. Rheolytic Thrombectomy With Percutaneous Coronary Intervention for Infarct Size Reduction in Acute Myocardial Infarction: 30-Day Results From a Multicenter Randomized Study J. Am. Coll. Cardiol., July 18, 2006; 48(2): 244 - 252. [Abstract] [Full Text] [PDF]

				A. Kaltoft, M. Bottcher, S. S. Nielsen, H.-H. T. Hansen, C. Terkelsen, M. Maeng, J. Kristensen, L. Thuesen, L. R. Krusell, S. D. Kristensen, et al. Routine Thrombectomy in Percutaneous Coronary Intervention for Acute ST-Segment-Elevation Myocardial Infarction: A Randomized, Controlled Trial Circulation, July 4, 2006; 114(1): 40 - 47. [Abstract] [Full Text] [PDF]

				L De Luca, G Sardella, C J Davidson, G De Persio, M Beraldi, T Tommasone, M Mancone, B L Nguyen, L Agati, M Gheorghiade, et al. Impact of intracoronary aspiration thrombectomy during primary angioplasty on left ventricular remodelling in patients with anterior ST elevation myocardial infarction Heart, July 1, 2006; 92(7): 951 - 957. [Abstract] [Full Text] [PDF]

				G. De Luca, H. Suryapranata, J. Timmer, J. P. Ottervanger, A. W.J. van't Hof, J. C.A. Hoorntje, J.-H. Dambrink, A.T. M. Gosselink, and M.-J. de Boer Impact of Routine Stenting on Clinical Outcome in Diabetic Patients Undergoing Primary Angioplasty for ST-Segment Elevation Myocardial Infarction Diabetes Care, April 1, 2006; 29(4): 920 - 923. [Full Text] [PDF]

				C. J. Terkelsen, B. L. Norgaard, J. F. Lassen, S. H. Poulsen, J. C. Gerdes, E. Sloth, L. B.-H. Gotzsche, F. K. Romer, L. Thuesen, T. T. Nielsen, et al. Potential significance of spontaneous and interventional ST-changes in patients transferred for primary percutaneous coronary intervention: observations from the ST-MONitoring in Acute Myocardial Infarction study (The MONAMI study) Eur. Heart J., February 1, 2006; 27(3): 267 - 275. [Abstract] [Full Text] [PDF]

				P. Staat, G. Rioufol, C. Piot, Y. Cottin, T. T. Cung, I. L'Huillier, J.-F. Aupetit, E. Bonnefoy, G. Finet, X. Andre-Fouet, et al. Postconditioning the Human Heart Circulation, October 4, 2005; 112(14): 2143 - 2148. [Abstract] [Full Text] [PDF]

				A. K. Bilge, Y. Nisanci, E. Yilmaz, B. Ozben, A. Oncul, F. Mercanoglu, and M. Meric Effects of Percutaneous Coronary Thrombectomywith the X-Sizer Catheter on Epicardial Flow and Microvascular Function in Acute Coronary Syndromes Clinical and Applied Thrombosis/Hemostasis, October 1, 2005; 11(4): 461 - 466. [Abstract] [PDF]

				M. Ferenc and F.-J. Neumann Efficacy of primary PCI: the microvessel perspective Eur. Heart J. Suppl., October 1, 2005; 7(suppl_I): I4 - I9. [Abstract] [Full Text] [PDF]

				A. W.J. van 't Hof, H. van de Wetering, N. Ernst, F. Hollak, F. de Pooter, H. Suryapranata, J. C.A. Hoorntje, J.-H. E. Dambrink, M. Gosselink, F. Zijlstra, et al. A quantitative analysis of the benefits of pre-hospital infarct angioplasty triage on outcome in patients undergoing primary angioplasty for acute myocardial infarction Eur. Heart J. Suppl., October 1, 2005; 7(suppl_K): K36 - K40. [Abstract] [Full Text] [PDF]

				M. Gick, N. Jander, H.-P. Bestehorn, R.-P. Kienzle, M. Ferenc, K. Werner, T. Comberg, K. Peitz, D. Zohlnhofer, V. Bassignana, et al. Randomized Evaluation of the Effects of Filter-Based Distal Protection on Myocardial Perfusion and Infarct Size After Primary Percutaneous Catheter Intervention in Myocardial Infarction With and Without ST-Segment Elevation Circulation, September 6, 2005; 112(10): 1462 - 1469. [Abstract] [Full Text] [PDF]

				P. Johanson, Y. Fu, S. G. Goodman, M. Dellborg, P. W. Armstrong, M. W. Krucoff, L. Wallentin, and G. S. Wagner A dynamic model forecasting myocardial infarct size before, during, and after reperfusion therapy: an ASSENT-2 ECG/VCG substudy Eur. Heart J., September 1, 2005; 26(17): 1726 - 1733. [Abstract] [Full Text] [PDF]

				I. Mizote, Y. Ueda, T. Ohtani, M. Shimizu, Y. Takeda, T. Oka, M. Tsujimoto, A. Hirayama, M. Hori, and K. Kodama Distal Protection Improved Reperfusion and Reduced Left Ventricular Dysfunction in Patients With Acute Myocardial Infarction Who Had Angioscopically Defined Ruptured Plaque Circulation, August 16, 2005; 112(7): 1001 - 1007. [Abstract] [Full Text] [PDF]

				M. Kosuge, K. Kimura, T. Ishikawa, T. Ebina, K. Hibi, N. Toda, and S. Umemura ST-Segment Depression in Lead aVR: A Useful Predictor of Impaired Myocardial Reperfusion in Patients With Inferior Acute Myocardial Infarction Chest, August 1, 2005; 128(2): 780 - 786. [Abstract] [Full Text] [PDF]

				T. Lefevre, E. Garcia, B. Reimers, I. Lang, C. di Mario, A. Colombo, F.-J. Neumann, M. V. Chavarri, P. Brunel, E. Grube, et al. X-Sizer for Thrombectomy in Acute Myocardial Infarction Improves ST-Segment Resolution: Results of the X-Sizer in AMI for Negligible Embolization and Optimal ST Resolution (X AMINE ST) Trial J. Am. Coll. Cardiol., July 19, 2005; 46(2): 246 - 252. [Abstract] [Full Text] [PDF]

				F. Burzotta, C. Trani, E. Romagnoli, M. A. Mazzari, A. G. Rebuzzi, M. De Vita, B. Garramone, F. Giannico, G. Niccoli, G. G.L. Biondi-Zoccai, et al. Manual Thrombus-Aspiration Improves Myocardial Reperfusion: The Randomized Evaluation of the Effect of Mechanical Reduction of Distal Embolization by Thrombus-Aspiration in Primary and Rescue Angioplasty (REMEDIA) Trial J. Am. Coll. Cardiol., July 19, 2005; 46(2): 371 - 376. [Abstract] [Full Text] [PDF]

				E. Ilkay, I. Karaca, M. Yavuzkir, M. Akbulut, and M. Pekdemir The Effect of Interventional Treatment in Acute Myocardial Infarction on ST Resolution: A Comparison of Coronary Angioplasty with Excimer Laser Angioplasty Angiology, July 1, 2005; 56(4): 377 - 384. [Abstract] [PDF]

				H S Gurm and E J Topol The ECG in acute coronary syndromes: new tricks from an old dog Heart, July 1, 2005; 91(7): 851 - 853. [Abstract] [Full Text] [PDF]

				A. Halkin, M. Singh, E. Nikolsky, C. L. Grines, J. E. Tcheng, E. Garcia, D. A. Cox, M. Turco, T. D. Stuckey, Y. Na, et al. Prediction of Mortality After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction: The CADILLAC Risk Score J. Am. Coll. Cardiol., May 3, 2005; 45(9): 1397 - 1405. [Abstract] [Full Text] [PDF]

				H.-K. Yip, C.-J. Wu, H.-W. Chang, C.-H. Yang, T.-H. Yu, Y.-H. Chen, and C.-L. Hang Prognostic Value of Circulating Levels of Endothelin-1 in Patients After Acute Myocardial Infarction Undergoing Primary Coronary Angioplasty Chest, May 1, 2005; 127(5): 1491 - 1497. [Abstract] [Full Text] [PDF]

				H Suryapranata, G De Luca, A W J van 't Hof, J P Ottervanger, J C A Hoorntje, J-H E Dambrink, A T M Gosselink, F Zijlstra, and M-J de Boer Is routine stenting for acute myocardial infarction superior to balloon angioplasty? A randomised comparison in a large cohort of unselected patients Heart, May 1, 2005; 91(5): 641 - 645. [Abstract] [Full Text] [PDF]

				G. De Luca, H. Suryapranata, G. W. Stone, D. Antoniucci, J. E. Tcheng, F.-J. Neumann, F. Van de Werf, E. M. Antman, and E. J. Topol Abciximab as Adjunctive Therapy to Reperfusion in Acute ST-Segment Elevation Myocardial Infarction: A Meta-analysis of Randomized Trials JAMA, April 13, 2005; 293(14): 1759 - 1765. [Abstract] [Full Text] [PDF]

				G. De Luca, A. W.J. van 't Hof, J. P. Ottervanger, J. C.A. Hoorntje, A.T. M. Gosselink, J.-H. E. Dambrink, M.-J. de Boer, and H. Suryapranata Ageing, impaired myocardial perfusion, and mortality in patients with ST-segment elevation myocardial infarction treated by primary angioplasty Eur. Heart J., April 1, 2005; 26(7): 662 - 666. [Abstract] [Full Text] [PDF]

				P. Sorajja, B. J. Gersh, C. Costantini, M. G. McLaughlin, P. Zimetbaum, D. A. Cox, E. Garcia, J. E. Tcheng, R. Mehran, A. J. Lansky, et al. Combined prognostic utility of ST-segment recovery and myocardial blush after primary percutaneous coronary intervention in acute myocardial infarction Eur. Heart J., April 1, 2005; 26(7): 667 - 674. [Abstract] [Full Text] [PDF]

				S. Agewall How should we evaluate an open artery in STEMI patients? Eur. Heart J., April 1, 2005; 26(7): 634 - 636. [Full Text] [PDF]

				G. W. Stone, J. Webb, D. A. Cox, B. R. Brodie, M. Qureshi, A. Kalynych, M. Turco, H. P. Schultheiss, D. Dulas, B. D. Rutherford, et al. Distal Microcirculatory Protection During Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Trial JAMA, March 2, 2005; 293(9): 1063 - 1072. [Abstract] [Full Text] [PDF]

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