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Genome-wide Linkage Analyses of Systolic Blood Pressure Using Highly Discordant Siblings Julia Krushkal, Robert Ferrell, Steve Mockrin, Stephen T. Turner, Charles F. Sing, and Eric Boerwinkle Condensed Abstract
We have performed a genome-wide linkage analysis of systolic blood pressure using a highly discordant sibling design. We have identified 4 regions of the human genome showing significant linkage to genes affecting systolic blood pressure variation, 2p22.1-2p21, 5q33.3-5q34, 6q23.1-6q24.1, and 15q25.1-15q26.1. These regions contain a number of candidate genes that are involved in physiological mechanisms of blood pressure regulation. These results provide novel information about genome regions influencing interindividual blood pressure variation and a basis for identifying the contributing genes.
Supplement
Linkage maps and marker information
Linkage plots for the 22 human autosomes
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