Files in this Data Supplement:

• Supplemental Methods - (Adobe Acrobat PDF) (81.5 kb)
• Figure I - (Adobe Acrobat PDF) (117 kb) Identification of the transplanted cells. (A) The site of cell grafting could be located macroscopically (white arrow) by co-injection of fluorescent beads. The stimulation bipolar electrode is identified by the yellow arrow. (B) Confocal image showing the presence of the microspheres (arrows) at the interface between the cardiomyocytes and fibroblasts. (C) High-magnification picture of the transplanted area. In this example the cells were prelabled with the fluorescent tracer DiO. The intense fluorescent signal emitted by the grafted cells enabled confirmation of the site of cell grafting.
• Figure II - (Adobe Acrobat PDF) (80.3 kb) One-dimensional model simulating action-potential propagation along 5 cardiomyocytes with myocyte-C connected to the engineered fibroblast. (R_o– extracellular resistance, C_m–membrane capacitance, R_myo, R_fib–longitudinal resistances, R_gapmm–resistance between myocytes, R_gapfm– resistance between myocyte and fibroblast), I_k the overexpressed potassium current.