(Circulation. 2006;114:II_567.)
© 2006 American Heart Association, Inc.
William W.L. Glenn Lecture: Surgical Cell-and Gene-Based Therapies |
Abstract 2717: No long-term Effects on Left Ventricular Function of Intracoronary Injection of Autologous Mononuclear Bone Marrow Cells in Acute Myocardial Infarction
1 RiksHospet Univ Hosp, Oslo, Norway
2 Ullevål Univ Hosp, Oslo, Norway
3 RiksHospet Univ Hosp, Oslo, Norway
4 Ullevål Univ Hosp, Oslo, Norway
5 RiksHospet Univ Hosp, Oslo, Norway
Background: Intracoronary injections of autologous mononuclear bone marrow cells (mBMC) in the acute phase of myocardial infarction (MI) has been proposed as an aid to improve myocardial function, however, long-term treament effects remain undetermined.
Methods: We studied 100 pts with acute anterior wall ST-elevation MI as defined by typical ECG pattern, CK-MB mass >3x upper reference level, and significant anterior wall motion abnormalities on echocardiography (>2 segments). All had PCI with stent on culprit lesion in proximal or mid LAD 2–12 hours after start of symptoms, none had previous Q-wave MI. Pts were randomized to either intracoronary injections of mBMC (median cell number 68x106) in LAD 4 – 8 days after MI (n=50), or control (n=50). Left ventricular function was assessed by echocardiography at baseline with repeated measurements 3, 6, and 12 months thereafter.
Results: Baseline characteristics of the groups were not different with age 57.4 (9.1) years, 16% females and max CK-MB mass (median) 369 µg/L.
Conclusion: mBMC treatment did not improve left ventricular global or regional function, nor remodeling as measured by LVEF, WMSI or LVEDV respectively, as compared to the control group during 12 months follow-up.
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