on March 11, 2002
Circulation. 2002
Published online before print March 11, 2002, doi: 10.1161/01.CIR.0000013838.94747.64
Published online before print March 11, 2002, doi: 10.1161/01.CIR.0000013838.94747.64
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on January 11, 2002
From the University of Michigan, Ann Arbor (R.D.B., S.R.); the University of Toronto, Toronto, Canada (J.R.B., B.U., F.S.); Environment Canada, Toronto (J.R.B.); and Health Canada (R.V.), Ottawa, Canada. * To whom correspondence should be addressed. E-mail: Robdbrok{at}umich.edu.
Background—Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function. Methods and Results—Twenty-five healthy adults underwent a randomized, double-blind, crossover study comparing the vascular response to the 2-hour inhalation of Conclusions—Short-term inhalation of fine particulate air pollution and ozone at concentrations that occur in the urban environment causes acute conduit artery vasoconstriction.
Revised on February 1, 2002
Accepted on February 5, 2002
Inhalation of Fine Particulate Air Pollution and
Ozone Causes Acute Arterial Vasoconstriction in Healthy
Adults
Robert D. Brook MD*,
150 µg/m3 of concentrated ambient fine particles (CAP) plus ozone (120 ppb) versus the response to the inhalation of filtered air. High-resolution vascular ultrasonography was used to measure alterations in brachial artery diameter, endothelial-dependent flow-mediated dilatation (FMD) and endothelial-independent nitroglycerin-mediated dilatation (NMD). Exposure to CAP plus ozone caused a significant brachial artery vasoconstriction compared with filtered air inhalation (-0.09±0.15 mm versus +0.01±0.18 mm, P=0.03). There were no significant differences in FMD (+0.29±4.11% versus -0.03±6.63%, P=0.88), NMD (+3.87±5.43% versus +3.46±7.92%, P=0.83), or blood pressure responses between exposures.
Key words: vasculature • endothelin • endothelium • air pollution
This article has been cited by other articles:
 |
|
 |
|
  K Bhaskaran, S Hajat, A Haines, E Herrett, P Wilkinson, and L Smeeth Effects of air pollution on the incidence of myocardial infarction Heart, November 1, 2009; 95(21): 1746 - 1759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Dales, S. Cakmak, and C. B. Vidal Air Pollution and Hospitalization for Headache in Chile Am. J. Epidemiol., October 15, 2009; 170(8): 1057 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Langrish, M. Lundback, N. L. Mills, N. R. Johnston, D. J. Webb, T. Sandstrom, A. Blomberg, and D. E. Newby Contribution of Endothelin 1 to the Vascular Effects of Diesel Exhaust Inhalation in Humans Hypertension, October 1, 2009; 54(4): 910 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Brook, B. Urch, J. T. Dvonch, R. L. Bard, M. Speck, G. Keeler, M. Morishita, F. J. Marsik, A. S. Kamal, N. Kaciroti, et al. Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans Hypertension, September 1, 2009; 54(3): 659 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Chuang, Z. Yang, D. G. Westbrook, M. Pompilius, C. A. Ballinger, C. R. White, D. M. Krzywanski, E. M. Postlethwait, and S. W. Ballinger Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis Am J Physiol Lung Cell Mol Physiol, August 1, 2009; 297(2): L209 - L216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Campen Nitric Oxide Synthase: "Enzyme Zero" in Air Pollution-Induced Vascular Toxicity Toxicol. Sci., July 1, 2009; 110(1): 1 - 3. [Full Text] [PDF]
|
|
|
|
|
|
T. R. Nurkiewicz, D. W. Porter, A. F. Hubbs, S. Stone, B. T. Chen, D. G. Frazer, M. A. Boegehold, and V. Castranova Pulmonary Nanoparticle Exposure Disrupts Systemic Microvascular Nitric Oxide Signaling Toxicol. Sci., July 1, 2009; 110(1): 191 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. C. Van Hee, S. D. Adar, A. A. Szpiro, R. G. Barr, D. A. Bluemke, A. V. Diez Roux, E. A. Gill, L. Sheppard, and J. D. Kaufman Exposure to Traffic and Left Ventricular Mass and Function: The Multi-Ethnic Study of Atherosclerosis Am. J. Respir. Crit. Care Med., May 1, 2009; 179(9): 827 - 834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Ying, P. Yue, X. Xu, M. Zhong, Q. Sun, M. Mikolaj, A. Wang, R. D. Brook, L. C. Chen, and S. Rajagopalan Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1540 - H1550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Hamade and C. G. Tankersley Interstrain variation in cardiac and respiratory adaptation to repeated ozone and particulate matter exposures Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1202 - R1215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L.S. Ljungman, N. Berglind, C. Holmgren, F. Gadler, N. Edvardsson, G. Pershagen, M. Rosenqvist, B. Sjogren, and T. Bellander Rapid effects of air pollution on ventricular arrhythmias Eur. Heart J., December 1, 2008; 29(23): 2894 - 2901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Totlandsdal, M. Refsnes, T. Skomedal, J.-B. Osnes, P. E. Schwarze, and M. Lag Particle-Induced Cytokine Responses in Cardiac Cell Cultures--the Effect of Particles versus Soluble Mediators Released by Particle-Exposed Lung Cells Toxicol. Sci., November 1, 2008; 106(1): 233 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M S Goldberg, N Giannetti, R T Burnett, N E Mayo, M-F Valois, and J M Brophy A panel study in congestive heart failure to estimate the short-term effects from personal factors and environmental conditions on oxygen saturation and pulse rate Occup. Environ. Med., October 1, 2008; 65(10): 659 - 666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Chuang, B. A. Coull, A. Zanobetti, H. Suh, J. Schwartz, P. H. Stone, A. Litonjua, F. E. Speizer, and D. R. Gold Particulate Air Pollution as a Risk Factor for ST-Segment Depression in Patients With Coronary Artery Disease Circulation, September 23, 2008; 118(13): 1314 - 1320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hwang, R. A. Kloner, M. T. Kleinman, and B. Z. Simkhovich Direct and Acute Cardiotoxic Effects of Ultrafine Air Pollutants in Spontaneously Hypertensive Rats and Wistar--Kyoto Rats Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2008; 13(3): 189 - 198. [Abstract] [PDF]
|
|
|
|
 |
|
 B. Z. Simkhovich, M. T. Kleinman, and R. A. Kloner Air Pollution and Cardiovascular Injury: Epidemiology, Toxicology, and Mechanisms J. Am. Coll. Cardiol., August 26, 2008; 52(9): 719 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M S O'Neill, A V Diez-Roux, A H Auchincloss, T G Franklin, D R Jacobs Jr, B C Astor, J T Dvonch, and J Kaufman Airborne particulate matter exposure and urinary albumin excretion: the Multi-Ethnic Study of Atherosclerosis Occup. Environ. Med., August 1, 2008; 65(8): 534 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley, H. C. Champion, E. Takimoto, K. Gabrielson, D. Bedja, V. Misra, H. El-Haddad, R. Rabold, and W. Mitzner Exposure to inhaled particulate matter impairs cardiac function in senescent mice Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R252 - R263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Diez Roux, A. H. Auchincloss, T. G. Franklin, T. Raghunathan, R. G. Barr, J. Kaufman, B. Astor, and J. Keeler Long-term Exposure to Ambient Particulate Matter and Prevalence of Subclinical Atherosclerosis in the Multi-Ethnic Study of Atherosclerosis Am. J. Epidemiol., March 15, 2008; 167(6): 667 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U P Santos, M Terra-Filho, C A Lin, L A A Pereira, T C B Vieira, P H N Saldiva, and A L F Braga Cardiac arrhythmia emergency room visits and environmental air pollution in Sao Paulo, Brazil J Epidemiol Community Health, March 1, 2008; 62(3): 267 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. N. Krivoshto, J. R. Richards, T. E. Albertson, and R. W. Derlet The Toxicity of Diesel Exhaust: Implications for Primary Care J Am Board Fam Med, January 1, 2008; 21(1): 55 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Briet, C. Collin, S. Laurent, A. Tan, M. Azizi, M. Agharazii, X. Jeunemaitre, F. Alhenc-Gelas, and P. Boutouyrie Endothelial Function and Chronic Exposure to Air Pollution in Normal Male Subjects Hypertension, November 1, 2007; 50(5): 970 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Mills, H. Tornqvist, M. C. Gonzalez, E. Vink, S. D. Robinson, S. Soderberg, N. A. Boon, K. Donaldson, T. Sandstrom, A. Blomberg, et al. Ischemic and Thrombotic Effects of Dilute Diesel-Exhaust Inhalation in Men with Coronary Heart Disease N. Engl. J. Med., September 13, 2007; 357(11): 1075 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tornqvist, N. L. Mills, M. Gonzalez, M. R. Miller, S. D. Robinson, I. L. Megson, W. MacNee, K. Donaldson, S. Soderberg, D. E. Newby, et al. Persistent Endothelial Dysfunction in Humans after Diesel Exhaust Inhalation Am. J. Respir. Crit. Care Med., August 15, 2007; 176(4): 395 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J B Henrotin, J P Besancenot, Y Bejot, and M Giroud Short-term effects of ozone air pollution on ischaemic stroke occurrence: a case-crossover analysis from a 10-year population-based study in Dijon, France Occup. Environ. Med., July 1, 2007; 64(7): 439 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Choi, Q.-S. Xu, S.-Y. Park, J.-H. Kim, S.-S. Hwang, K.-H. Lee, H.-J. Lee, and Y.-C. Hong Seasonal variation of effect of air pollution on blood pressure J Epidemiol Community Health, April 1, 2007; 61(4): 314 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Pope III, J. B. Muhlestein, H. T. May, D. G. Renlund, J. L. Anderson, and B. D. Horne Ischemic Heart Disease Events Triggered by Short-Term Exposure to Fine Particulate Air Pollution Circulation, December 5, 2006; 114(23): 2443 - 2448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Maitre, V. Bonneterre, L. Huillard, P. Sabatier, and R. de Gaudemaris Impact of urban atmospheric pollution on coronary disease Eur. Heart J., October 1, 2006; 27(19): 2275 - 2284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bhatnagar Environmental Cardiology: Studying Mechanistic Links Between Pollution and Heart Disease Circ. Res., September 29, 2006; 99(7): 692 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Li, X. Hyseni, J. D. Carter, J. M. Soukup, L. A. Dailey, and Y.-C. T. Huang Pollutant particles enhanced H2O2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells Am J Physiol Cell Physiol, August 1, 2006; 291(2): C357 - C365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cozzi, S. Hazarika, H. W. Stallings III, W. E. Cascio, R. B. Devlin, R. M. Lust, C. J. Wingard, and M. R. Van Scott Ultrafine particulate matter exposure augments ischemia-reperfusion injury in mice Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H894 - H903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Brook, M. S. O'Neill, and S. Rajagopalan Letter by Brook et al Regarding Article "Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis" Circulation, June 20, 2006; 113(24): e871 - e871. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Thomson, P. Kumarathasan, and R. Vincent Pulmonary Expression of PreproET-1 and PreproET-3 mRNAs Is Altered Reciprocally in Rats After Inhalation of Air Pollutants. Experimental Biology and Medicine, June 1, 2006; 231(6): 979 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Ballester, P Rodriguez, C Iniguez, M Saez, A Daponte, I Galan, M Taracido, F Arribas, J Bellido, F B Cirarda, et al. Air pollution and cardiovascular admissions association in Spain: results within the EMECAS project. J Epidemiol Community Health, April 1, 2006; 60(4): 328 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Sun, A. Wang, X. Jin, A. Natanzon, D. Duquaine, R. D. Brook, J.-G. S. Aguinaldo, Z. A. Fayad, V. Fuster, M. Lippmann, et al. Long-term Air Pollution Exposure and Acceleration of Atherosclerosis and Vascular Inflammation in an Animal Model JAMA, December 21, 2005; 294(23): 3003 - 3010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Mills, H. Tornqvist, S. D. Robinson, M. Gonzalez, K. Darnley, W. MacNee, N. A. Boon, K. Donaldson, A. Blomberg, T. Sandstrom, et al. Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis Circulation, December 20, 2005; 112(25): 3930 - 3936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Maheswaran, R. P. Haining, P. Brindley, J. Law, T. Pearson, P. R. Fryers, S. Wise, and M. J. Campbell Outdoor air pollution, mortality, and hospital admissions from coronary heart disease in Sheffield, UK: a small-area level ecological study Eur. Heart J., December 1, 2005; 26(23): 2543 - 2549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Campen, N. S. Babu, G. A. Helms, S. Pett, J. Wernly, R. Mehran, and J. D. McDonald Nonparticulate Components of Diesel Exhaust Promote Constriction in Coronary Arteries from ApoE-/- Mice Toxicol. Sci., November 1, 2005; 88(1): 95 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Thomson, P. Kumarathasan, P. Goegan, R. A. Aubin, and R. Vincent Differential Regulation of the Lung Endothelin System by Urban Particulate Matter and Ozone Toxicol. Sci., November 1, 2005; 88(1): 103 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Zeka, A Zanobetti, and J Schwartz Short term effects of particulate matter on cause specific mortality: effects of lags and modification by city characteristics Occup. Environ. Med., October 1, 2005; 62(10): 718 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rajagopalan, Q. Sun, and L. C. Chen Particulate Pollution and Endothelial Function: Deja Vu All Over Again in the Air Circulation, June 7, 2005; 111(22): 2869 - 2871. [Full Text] [PDF]
|
|
|
|
|
|
M. S. O'Neill, A. Veves, A. Zanobetti, J. A. Sarnat, D. R. Gold, P. A. Economides, E. S. Horton, and J. Schwartz Diabetes Enhances Vulnerability to Particulate Air Pollution-Associated Impairment in Vascular Reactivity and Endothelial Function Circulation, June 7, 2005; 111(22): 2913 - 2920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Wellenius, T. F. Bateson, M. A. Mittleman, and J. Schwartz Particulate Air Pollution and the Rate of Hospitalization for Congestive Heart Failure among Medicare Beneficiaries in Pittsburgh, Pennsylvania Am. J. Epidemiol., June 1, 2005; 161(11): 1030 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-B. Ruidavets, M. Cournot, S. Cassadou, M. Giroux, M. Meybeck, and J. Ferrieres Ozone Air Pollution Is Associated With Acute Myocardial Infarction Circulation, February 8, 2005; 111(5): 563 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. de Paula Santos, A. L. F. Braga, D. M. A. Giorgi, L. A. A. Pereira, C. J. Grupi, C. A. Lin, M. A. Bussacos, D. M. T. Zanetta, P. H. do Nascimento Saldiva, and M. T. Filho Effects of air pollution on blood pressure and heart rate variability: a panel study of vehicular traffic controllers in the city of Sao Paulo, Brazil Eur. Heart J., January 2, 2005; 26(2): 193 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Peters, S. von Klot, M. Heier, I. Trentinaglia, A. Hormann, H. E. Wichmann, H. Lowel, and the Cooperative Health Research in the Region of A Exposure to Traffic and the Onset of Myocardial Infarction N. Engl. J. Med., October 21, 2004; 351(17): 1721 - 1730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zanobetti, M. J. Canner, P. H. Stone, J. Schwartz, D. Sher, E. Eagan-Bengston, K. A. Gates, L. H. Hartley, H. Suh, and D. R. Gold Ambient Pollution and Blood Pressure in Cardiac Rehabilitation Patients Circulation, October 12, 2004; 110(15): 2184 - 2189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.E. Sharman, J.R. Cockcroft, and J.S. Coombes Cardiovascular implications of exposure to traffic air pollution during exercise QJM, October 1, 2004; 97(10): 637 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Brook, B. Franklin, W. Cascio, Y. Hong, G. Howard, M. Lipsett, R. Luepker, M. Mittleman, J. Samet, S. C. Smith Jr, et al. Air Pollution and Cardiovascular Disease: A Statement for Healthcare Professionals From the Expert Panel on Population and Prevention Science of the American Heart Association Circulation, June 1, 2004; 109(21): 2655 - 2671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rajagopalan, E. C. Somers, R. D. Brook, C. Kehrer, D. Pfenninger, E. Lewis, A. Chakrabarti, B. C. Richardson, E. Shelden, W. J. McCune, et al. Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity Blood, May 15, 2004; 103(10): 3677 - 3683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Adamkiewicz, S Ebelt, M Syring, J Slater, F E Speizer, J Schwartz, H Suh, and D R Gold Association between air pollution exposure and exhaled nitric oxide in an elderly population Thorax, March 1, 2004; 59(3): 204 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bhatnagar Cardiovascular pathophysiology of environmental pollutants Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H479 - H485. [Full Text] [PDF]
|
|
|
|
|
|
C. A. Pope III, R. T. Burnett, G. D. Thurston, M. J. Thun, E. E. Calle, D. Krewski, and J. J. Godleski Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease Circulation, January 6, 2004; 109(1): 71 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Verrier, M. A. Mittleman, and P. H. Stone Air Pollution: An Insidious and Pervasive Component of Cardiac Risk Circulation, August 20, 2002; 106(8): 890 - 892. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Suzuki Expanding the health care debate Can. Med. Assoc. J., June 1, 2002; 166(13): 1678 - 1679. [Full Text] [PDF]
|
|